Renal cell carcinoma metastatic to the pancreas: a single-institution series and review of the literature

Kassabian, Armen; Stein, John P.; Jabbour, Nicolas; Parsa, Kambiz; Skinner, Donald G.; Parekh, Dilip; Cosenza, Carlos Alberto Nunes; Selby, Rick

doi:10.1016/s0090-4295(00)00639-7

Cited by 153 publications

(113 citation statements)

References 8 publications

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“…However, gastric metastasis attributable to RCC occurs after a significantly longer interval; the mean (median, range) time to diagnosis of gastric metastasis in the present cases and those reported previously was 6.5 (4.7, 0.1-20) years. Thus, gastric metastasis seems to be a late event in patients with RCC, similar to the occurrence of secondary pancreatic [25,26] and thyroid [27,28] involvement.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review

Pollheimer¹,

Hinterleitner²,

Pollheimer³

et al. 2008

BJU International

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diagnosis of cancer in gastric biopsies or resection specimens. The histopathological slides of both renal and gastric cancer probes, and the clinical presentation, treatment and outcome of affected patients, were reassessed. RESULTSTwelve patients with primary gastric cancer, one with local RCC recurrence affecting the antrum and five with clear cell RCC (three men and two women; mean age 73 years, range 65-83) with haematogenous cancer spread to the stomach were detected. The mean (range) time to gastric metastasis was 6.9 (1.7-13.1) years. There were metastases to other organs, most often the lung, in all patients.

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Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review

Pollheimer¹,

Hinterleitner²,

Pollheimer³

et al. 2008

BJU International

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“…[7] The longest period between the primary cancer and the development of pancreatic metastasis was 15-22 years. [5,8] In the present study, the longest period was 27 years. Wente et al, suggest that the follow-up period in patients with early-stage RCC should extend beyond 20 years for the detection of recurrence or metastatic disease.…”

Section: Discussionmentioning

confidence: 53%

“…[5] Metastasis to the pancreas occurs mostly from kidney, lung, breast, colon, and skin cancers, and is often associated with diffuse systemic disease. [6] Although RCC can metastasize to any organ through the venous and lymphatic systems, the most common sites of metastasis are the lungs, bones, liver, and brain.…”

Section: Discussionmentioning

confidence: 99%

The role of surgery in renal cell carcinoma with pancreatic metastasis

Chang¹,

Liaw²,

Chuang³

2015

Biomed J

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Metastasis of renal cell carcinoma to the pancreas is uncommon and, in most cases, presents as a single pancreatic mass that shows a more favorable prognosis than primary pancreatic tumors. We examined patients with renal cell carcinoma metastatic to the pancreas, and discuss the clinical findings, treatment administered, and final outcomes. The present study is a retrospective analysis of renal cell carcinoma patients with pancreatic metastasis. Pancreatic tumor specimens were obtained by surgical excision, surgical biopsy, fine-needle biopsy, or endoscopic ultrasound biopsy. The surgical approaches included distal splenopancreatectomy, total pancreatectomy, or distal pancreatectomy. The physician determined the postoperative treatment regimen with interferon-α or targeted therapy on the basis of patient's performance. A total of six patients with median age of 50 years were included in the study. The median time from the primary nephrectomy to the development of pancreatic metastasis was 16 years. In the biopsy-only group, the mean stable disease period was 16.5 months. In the patients treated with surgery combined with interferon-α or targeted therapy, the mean stable disease period was 29.5 months. The patients treated with repeat mastectomy showed a mean stable disease period of 33.3 months. Aggressive surgical management is more effective than observation or immunotherapy. Recent advances in the design of targeted therapies may provide alternative treatment strategies. Combination therapy may play an important role in the future. Considering patient compliance and cost-effectiveness, resection of pancreatic metastasis is currently the first choice of treatment. (Biomed J 2015;38:173-176)

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“…3, Fig. 4), contrairement aux tumeurs primitives du pancréas, qui sont hypovascularisées 1,3,[7][8][9][10] . Cependant, le diagnostic final est établi par un examen anatomopathologique après exérèse chirurgicale de la lésion 3 .…”

Section: Discussionunclassified