Renal Cell Carcinoma in Children: Experience at a Single Institution in Japan

Asanuma, Hiroshi; Nakai, Hideo; Takeda, Masatoshi; Shishido, Seiichiro; Tajima, Eiji; Hara, Hiroko; Morikawa, Yukihiko; Kawamura, Takeshi

doi:10.1097/00005392-199910000-00065

Cited by 11 publications

(28 citation statements)

References 21 publications

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“…Nach Abschluss der Induktionschemotherapie zeigte das MRT des Abdomens lediglich eine geringe Grö-ßenreduktion des Tumors (⊡ Abb. 4 …”

Section: Therapieunclassified

“…Nierenzellkarzinome stellen im Kindesalter zweifelsohne eine Rarität dar.Sie machen 0,05% der kindlichen Tumoren und 2,3-6,6% der kindlich renalen Tumoren aus [10].Insgesamt wurden ca.300 Fälle in der Weltliteratur beschrieben [4], welche neben kasuistischen Berichten in wenigen Übersichtsarbeiten zusammengefasst sind [3,4,6,8,10].…”

Section: Diskussion Und üBersichtunclassified

“…Lebensjahr, nach dem 10. Lebensjahr treten Wilms-Tumoren selten auf [4,10,12]. Die Inzidenz des Nierenzellkarzinoms im Kindesalter scheint stark altersabhängig zu sein,mehrere Autoren bestätigen eine Zunahme in der 2.…”

Section: Altersabhängige Inzidenzunclassified

“…Die initiale Bildgebung erlaubt häufig keine Differenzierung zum Wilms-Tumor [4,12]. Die Zweitbegutachtung der Studienzentrale ergab eine diagnostische Treffsicherheit für die Diagnose "Wilms-Tumor" der primären Diagnostika allein (Sonographie und Ausscheidungsurographie) in 93%, sodass durch den heute üb-lichen Einsatz von CT und/oder MRT die diagnostische Sicherheit noch weit höher anzusiedeln ist [12].…”

Section: Differenzialdiagnoseunclassified

“…Wie in unserem Fall können in ca.25% Kalzifikationen auf ein papilläres Nierenzellkarzinom hinweisen [20], da sie bei Wilms-Tumoren lediglich in ca.5% anzutreffen sind [4,8] (⊡ Abb.2).Nach Neuroblastomausschluss mittels Katecholaminbestimmung im Urin und MIBG-Szintigraphie werden die Patienten an die Studienzentrale gemeldet, nach international üblichen Kriterien zweitbegutachtet und, wenn als Wilms-Tumor eingestuft, bis zum Erhalt der Referenzhistologie nach standardisiertem Schema behandelt.…”

Section: Introductionunclassified

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Das Nierenzellkarzinom im Kindesalter

et al. 2003

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Renal cell carcinoma (RCC) in childhood is rare and its incidence is estimated to be 3-6% of all kidney cancers in childhood. Thus, clinical experience with renal cell carcinoma in this age group is meager and no consensus between pediatric urologists and pediatric oncologists exists on common treatment strategies. Furthermore, most previous reports included postpubertal patients in whom the biological behavior of the RCC and treatment options are the same as in adults. Based on the literature and a clinical case report of a 12-year-old boy suffering from a papillary renal cell carcinoma stage IV (pT2 N2 MO), the relevance of the biological behavior of different histological subtypes and their treatment options are reviewed and discussed. In adulthood lymph node dissection is still controversial, but in children it seems to have a positive effect on survival. Immunotherapy in childhood is still and experimental option and just a few cases are reported in the literature.

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“…Nach Abschluss der Induktionschemotherapie zeigte das MRT des Abdomens lediglich eine geringe Grö-ßenreduktion des Tumors (⊡ Abb. 4 …”

Section: Therapieunclassified

Section: Diskussion Und üBersichtunclassified

Section: Altersabhängige Inzidenzunclassified

Section: Differenzialdiagnoseunclassified

Section: Introductionunclassified

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Das Nierenzellkarzinom im Kindesalter

et al. 2003

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Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma

Geller

Dome

2004

Cancer

148

166

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BACKGROUND Local lymph node involvement in adults with renal cell carcinoma (RCC) is associated with poor outcome. The prognostic significance of local lymph node involvement in children with RCC has not been studied systematically. METHODS A retrospective review of patients treated at St Jude Children's Research Hospital (Memphis, TN) and an extensive review of the medical literature were undertaken to evaluate the prognostic significance of local lymph node involvement in pediatric RCC. RESULTS Thirteen patients with the diagnosis of RCC were treated at St. Jude since the hospital's inception in 1962. Four patients presented with lymph node‐positive, distant metastasis‐negative (N+M0) disease, and all 4 remain disease free after resection without adjuvant therapy (follow‐up duration, 2–9 years). A systematic review of the literature including 243 pediatric patients with RCC revealed stage‐specific survival rates of 92.5%, 84.6%, 72.7%, and 12.7% for Stage I–IV disease, respectively. Of 58 children with N+M0 RCC for whom outcome data were available, 42 (72.4%) were alive without disease at last follow‐up. Among patients whose therapy could be discerned, those who received no adjuvant therapy fared as well (15 of 16 alive) as those who received various adjuvant treatments (22 of 31 alive). CONCLUSIONS Children with lymph node–positive RCC in the absence of distant metastatic disease had a relatively favorable long‐term prognosis, with survival rate nearly triple those of adult historical controls. Until highly effective therapies for RCC are identified, these children should not be exposed to adjuvant treatment. Further investigation of the biologic differences between adult and pediatric RCC is warranted. Cancer 2004. © 2004 American Cancer Society.

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Renal cell carcinoma in children under 10 years old: a presentation of four cases

Labanaris

Schott²,

Zugor³

2007

Pediatr Surg Int

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Renal cell carcinoma (RCC) in childhood is a unique disease entity, representing only 2.3-6.6% of all renal tumors in children. Most experience with pediatric RCC is limited to case reports or case series consisting of relatively small numbers of cases. The aim of this study is to present four additional cases of this unique disease entity. The records of four patients presenting to our institution with renal cell carcinoma between 1986 and 2006 were examined. Only patients younger than 10 years were included. The clinical data included age, sex, signs and symptoms, surgery performed and clinical outcome. Data recorded from the pathology reports included tumor size, histologic subtype, grade (WHO), and stage (TNM). There were three boys and one girl aged between 11 months and 10 years at presentation. The classic triad of flank pain, gross hematuria and palpable abdominal mass were not encountered. A histopathological diagnosis of RCC was confirmed in all four cases without any positive lymph node involvement. Due to the increased detection of tumors with the use of imaging techniques such as ultrasound and computerized tomography, an increased number of incidentally diagnosed RCCs are found. The primary choice of the treatment of any stage of RCC is surgical excision. However, the preoperative diagnosis of tumor in children is difficult and the effects of chemotherapy, including immunotherapy, are unclear.

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Renal Cell Carcinoma in Children: Experience at a Single Institution in Japan

Cited by 11 publications

References 21 publications

Das Nierenzellkarzinom im Kindesalter

Das Nierenzellkarzinom im Kindesalter

Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma

Renal cell carcinoma in children under 10 years old: a presentation of four cases

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