Renal cell carcinoma in childhood and adolescence: A retrospective survey for prognostic factors in 22 cases

Aronson, Daniël C.; Medary, Irene; Finlay, Jonathan L.; Herr, Harry W.; Exelby, Philip R.; Quaglia, Michael P. La

doi:10.1016/s0022-3468(96)90344-9

Cited by 54 publications

(71 citation statements)

References 14 publications

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“…Previous retrospective studies of RCC in children [2,3,5,[15][16][17][18][19][20][21][22][23] collectively show a mean age at presentation of 9-11 years; a lack of a male predominance; a 30-60% incidence of pain, mass, and hematuria, with virtual absence of the triad of all three; and a 50-70% overall survival, with a dismal prognosis for metastatic disease. Our results were similar, but in addition, we found a higher frequency of paraneoplastic phenomena (31%); two patients with polycythemia, four with hypertension, one with fever, and one with weight loss.…”

Section: Discussionmentioning

confidence: 99%

Renal-cell carcinoma in children: A different disorder from its adult counterpart?

Carção

Taylor

Greenberg

et al. 1998

Med. Pediatr. Oncol.

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Section: Discussionmentioning

confidence: 99%

Renal-cell carcinoma in children: A different disorder from its adult counterpart?

Carção

Taylor

Greenberg

et al. 1998

Med. Pediatr. Oncol.

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“…The completeness of the surgical resection has been shown to be a significant prognostic factor, with survival rates as low as 10% after incomplete resection [10]. The effects of chemotherapy, including immunotherapy, are unclear.…”

Section: Discussionmentioning

confidence: 99%

Renal Cell Carcinoma in Children: About Two Case Report

Louati¹,

Jlidi²,

Charieg³

2016

Med Surg Urol

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“…Clear cell RCC accounts for ~75% of renal cell tumors; the other subtypes are typically summarized under the term non-clear cell RCC (5,6). RCC typically develops during adulthood, affecting individuals >40 years of age, with the incidence peaking during the sixth and seventh decades of life.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal lymph node metastasis of renal cell carcinoma: A case report

et al. 2016

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Abstract. Renal cell carcinoma (RCC) may metastasize to mediastinal lymph nodes without any abdominal lymph node involvement. The present study describes an autopsy-proven case of RCC presenting with a large mediastinal mass; the case had been previously misdiagnosed as small cell lung carcinoma due to imaging analysis results, an elevated serum level of neuron-specific enolase and the presence of small atypical cells with a high nuclear/cytoplasmic ratio. Despite RCC occurrence being rare, it should be considered in the differential diagnosis, particularly when a mass located in the kidneys presents with metastases to the mediastinal lymph nodes, even if there is no involvement of the abdominal lymph nodes and the primary lesion is of a small size. IntroductionRenal cell carcinoma (RCC) accounts for 95% of renal neoplasms and ~3% of adult malignancies (1). In the United States, ~61,560 patients with RCC were identified and 14,080 patients were predicted to have succumbed to the disease in 2015 (2). Generally, patients with RCC present with gross hematuria, flank pain and a palpable mass; however, these symptoms are not always present. RCC is a heterogeneous disease and several histological subtypes have been categorized according to the 2004 World Health Organization (WHO) renal tumor classification (3). The mortality rate of patients with RCC depends on the histological subtype and the clinical stage of the tumor. Since RCC has a hemorrhagic tendency, biopsy of the tumor is disputed (4). A diagnosis of RCC is provided according to the results observed using imaging methodologies, including computed tomography (CT), and a diagnosis of RCC is confirmed by the surgical removal of the tumor en bloc. The present study reports the case of a patient who presented with a large, right mediastinal mass appearing to mimic small cell lung cancer (SCLC); however, following autopsy examination, the diagnosis was confirmed as RCC. Case reportA 56-year-old male presented at the Ryugasaki Saiseikai Hospital (Ryugasaki, Japan) in September 2011 with a dry cough that had persisted for 3 months. Physical examination identified decreased breath sounds at the right hemithorax. Laboratory evaluations were undertaken and included urinalysis and testing of blood urea nitrogen, creatinine and serum calcium concentrations. All laboratory analyses were normal, with the exception of an increased concentration of white blood cells (12,100 cells/µl; normal range, 3,900-9,800 cells/µl), C-reactive protein (12.9 mg/dl; normal range, 0.0-0.3 mg/dl) and serum neuron-specific enolase (NSE; 50.0 ng/ml; normal range, 0.0-16.3 ng/ml). Following a CT scan of the chest, a large mass was detected at the right mediastinum, extending directly to the heart, with the presence of pericardial fluid (Fig. 1). Pleural fluid was identified in the right hemithorax, but no abnormalities were observed in the lungs and the abdominal lymph nodes were not swollen. However, a small nodule was detected in the upper pole of the right kidney. A bronchoscopy was performe...

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Renal cell carcinoma in childhood and adolescence: A retrospective survey for prognostic factors in 22 cases

Cited by 54 publications

References 14 publications

Renal-cell carcinoma in children: A different disorder from its adult counterpart?

Renal-cell carcinoma in children: A different disorder from its adult counterpart?

Renal Cell Carcinoma in Children: About Two Case Report

Mediastinal lymph node metastasis of renal cell carcinoma: A case report

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