Renal Cell Carcinoma in Children: About Two Case Report

Louati, Hamdi; Jlidi, S.; Charieg, A.

doi:10.4172/2168-9857.1000173

Cited by 2 publications

(7 citation statements)

References 14 publications

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“…Mean age presentantion in children is 9-10 years. It corresponds to 1.4% of renal tumors in patients under 4 years old, between 5 and 9 years incidence is 15.2% and 52.6% between 10 and 15 years old (3) .In the second decade of life, it is as common as Wilms tumor. Since 1986, approximately 160 well-documented cases have been published in the literature (4) .…”

Section: Macroscopicallymentioning

confidence: 99%

“…Despite the risk factors observed in adults (obesity, smoking, dialysis, hypertenstion, abuse of nonsteroidal anti-inflammatory drugs, syndromes such as tuberous sclerosis, radiotherapy for testicular tumors), there is no such correlation in children (3) .…”

Section: Macroscopicallymentioning

confidence: 99%

“…Using immunohistochemical staining, recent studies have reported Xp11.2 translocations in 20% to 70% of pediatric RCC (3) . There is also translocation related with PRCC-TFE3 gene and X chromosomes, which leads to overexpression of TFE3 protein in children and young adults.…”

Section: A) Genetic Associationmentioning

confidence: 99%

“…In stage I, surgery can be curative. The completeness of the surgical resection with radical nephrectomy has been shown to be a significant prognostic factor, with survival rates as low as 10% after incomplete resection, given that current adjuvant medical therapies are not typically curative for unresected disease (3,12,14) .…”

Section: F) Treatmentmentioning

confidence: 99%

“…The main prognosis factors are tumor stage and size, vascular invasion, age, location, celular sub-type. However, tumor stage appears to be the most important factor for the survival (3) . Reports of RCC found overall survival rate of 56-64% in pediatric population, which can be improved to 66.6% the use of adjuvant chemotherapy and radiotherapy.…”

Section: G) Prognosismentioning

confidence: 99%

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Clear - cell renal carcinoma: review of literature in pediatric population / Carcinoma renal de células-claras: revisão bibliográfica na população pediátrica

Orellana

Traete

Campos

et al. 2020

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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ABSTRACT:Introduction: The first reports of renal tumors originated from the renal tubule epithelium date from 1855, Robin, and 1867, Waldeyer. However, at the same era, some pathologists wrong believed these tumors were originated from adrenal gland tissues due to the fat content of the tumor (hypernephroid tumor theory - origin above the kidney, 1894). The first diagnostic test for renal tumor was excretory urography. Over the years, with the emergence of ultrasonography (US), it has been replaced. Nowadays, after the US screening, all renal lesions should be evaluated, in a complementary way, with computed tomography (CT) - gold standard - in the pre-contrast, arterial, portal, nephrographic phases. This is necessary to characterize the presence of enhancement after contrast. A kidney injury that enhances more than 15 Housfield units (UH) is suspected of kidney cell cancer. There are different subtypes of renal tumors derived from various sites of the nephron. Clear cell Renal Cell Carcinoma (RCC) is one of the subtypes that originates from the renal cortex. It is a rare tumor in children. Objective: The aim of this chapter is to review de incidence, pathology, diagnosis and treatment in clear-cell renal carcinoma in pediatric population. Methods: The authors performed a literary review about clear-cell renal carcinoma in pediatric population using Pubmed Database and Campbell-Walsh Urology as source search.Keywords: Renal cell carcinoma, Tumor, Pediatrics, Kidney, Nefrectomy ResumoRESUMO:Introdução: Os primeiros relatos de tumores renais originados do epitélio do túbulo renal datam de 1855, Robin, e 1867, Waldeyer. Contudo, na mesma época, alguns patologistas acreditavam erroneamente que esses tumores provinham dos tecidos das glândulas supra-renais, devido ao teor de gordura do tumor (hypernephroid tumor theory – origem acima do rim, 1894). O primeiro teste diagnóstico para tumor renal foi a urografia excretora. Ao longo dos anos, com o surgimento da ultrassonografia, esse teste foi substituído. Atualmente, após a leitura da ultrassonografia, todas as lesões renais devem ser avaliadas, de forma complementar, com tomografia computadorizada (TC) – padrão ouro – nas fases pré-contraste, arterial, porta e nefrográfica. Isso é necessário para caracterizar a presença de melhora após contraste. Uma lesão renal que aumenta mais de 15 unidades Housfield (UH) é suspeita de câncer de células renais. Existem diferentes subtipos de tumores derivados de vários locais do néfron. O carcinoma de células renais de células claras (CCR) é um dos subtipos originários do córtex renal. É um tumor raro em crianças. Objetivo: O objetivo deste capítulo é revisar a incidência, a patologia, o diagnóstico e o tratamento do CCR na população pediátrica. Método: Os autores realizaram uma revisão literária sobre carcinoma renal de células claras em população pediátrica usando a base de dados PubMed e o livro Campbell-Walsh de Urologia como fonte de pesquisa.Palavras chave: Carcinoma de células renais, Tumor, Pediatria, Rim, Nefrectomia

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Section: Macroscopicallymentioning

confidence: 99%

Section: Macroscopicallymentioning

confidence: 99%

Section: A) Genetic Associationmentioning

confidence: 99%

Section: F) Treatmentmentioning

confidence: 99%

Section: G) Prognosismentioning

confidence: 99%

See 3 more Smart Citations

Clear - cell renal carcinoma: review of literature in pediatric population / Carcinoma renal de células-claras: revisão bibliográfica na população pediátrica

Orellana

Traete

Campos

et al. 2020

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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Metastatic Papillary Renal Cell Carcinoma in a 13-Year Old Girl: A Case Report and Review of the Literature Mainly Focusing on Treatment and Prognosis

Yahaya

Bartholomew

Mremi³

2020

International Journal of Surgery Case Reports

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Highlights Renal cell carcinoma affecting the pediatric population is extremely rare. Papillary variant of the pediatric renal cell carcinoma is the most common type. The prognosis of childhood renal cell carcinoma is poorer than that of the general population. Majority of children with renal cell carcinoma have metastasis at diagnosis.

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Renal Cell Carcinoma in Children: About Two Case Report

Cited by 2 publications

References 14 publications

Clear - cell renal carcinoma: review of literature in pediatric population / Carcinoma renal de células-claras: revisão bibliográfica na população pediátrica

Clear - cell renal carcinoma: review of literature in pediatric population / Carcinoma renal de células-claras: revisão bibliográfica na população pediátrica

Metastatic Papillary Renal Cell Carcinoma in a 13-Year Old Girl: A Case Report and Review of the Literature Mainly Focusing on Treatment and Prognosis

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