Renal cell carcinoma and tumour thrombus in the inferior vena cava: clinical outcome of 98 consecutive patients and the prognostic value of preoperative parameters

Niedworok, Christian; Dörrenhaus, Bettina; Dorp, F. vom; Piotrowski, Jarowit; Tschirdewahn, Stephan; Szarvas, Tibor; Rübben, H.; Schenck, M.

doi:10.1007/s00345-014-1449-4

Cited by 17 publications

(16 citation statements)

References 26 publications

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“…Several clinicopathological factors influenced patients' survival. In previous studies, ECOG performance score was influenced by patients' survival . In the present study, ECOG performance status was also influenced by OS and CSS in patients with pN any M any .…”

Section: Discussionsupporting

confidence: 61%

“…Lower BMI indicated poor nutrition status. Higher BMI was associated with better postoperative performance, at least for OS . In the present study, higher BMI affected lower CSS in patients with non‐metastatic RCC.…”

Section: Discussionsupporting

confidence: 52%

“…In previous studies, ECOG performance score was influenced by patients' survival. 4,30 In the present study, ECOG performance status was also influenced by OS and CSS in patients with pN any M any . As known, clinical tumor size also influenced OS and CSS.…”

Section: Discussionsupporting

confidence: 50%

“…Furthermore, for non‐metastatic patients, remnant venous thrombus correlated significantly with a poor prognosis. In patients with remnant venous thrombus, the risk of postoperative cardiopulmonary venous thromboembolic events is increased . The influence of BMI has been published in several studies.…”

Section: Discussionmentioning

confidence: 99%

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Surgical treatment of renal cell carcinoma: Can morphological features of inferior vena cava tumor thrombus on computed tomography or magnetic resonance imaging be a prognostic factor?

et al. 2017

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Objectives: To evaluate the impact of morphological features of inferior vena cava thrombus on the overall survival and cancer-specific survival (cancer-specific survival of patients with renal cell carcinoma). Methods: We retrospectively analyzed the records of 156 renal cell carcinoma patients with inferior vena cava thrombus who underwent radical nephrectomy and thrombectomy from 1998 to 2013 at five tertiary centers. Inferior vena cava thrombi were classified as spherical (type I) and spiculated (type II) according to morphological features on computed tomography or magnetic resonance imaging. Multivariate cox regression models were used to quantify the impact of prognostic factors on overall survival and cancer-specific survival. Results: Type I was found in 29 patients (18.6%), and type II in 127 patients (81.4%). Median follow up was 38.2 months (interquartile range 12-57). Demographic characteristics were not significantly different, except for the cranial thrombus height (P = 0.003). On multivariate analysis, Eastern Cooperative Oncology Group performance score, clinical tumor size, distant metastasis, histologic subtype, thrombus morphology and remnant venous thrombus significantly affected overall survival in pN any M any patients (all P < 0.05). Among the pN O / X M O patients, clinical tumor size, histologic subtype, thrombus morphology and remnant venous thrombus significantly affected overall survival (all P < 0.05). In terms of cancer-specific survival, Eastern Cooperative Oncology Group performance score, clinical tumor size, distant metastasis, histologic subtype and thrombus morphology significantly affected cancer-specific survival in pN any M any patients (all P < 0.05). In patients with pN O / X M O , body mass index, clinical tumor size, histological subtype, thrombus morphology and remnant venous thrombus significantly affected cancer-specific survival (all P < 0.05). Conclusion: Clinical tumor size, histological subtype, and thrombus morphology are independent predictors of overall survival and cancer-specific survival in renal cell carcinoma patients with inferior vena cava thrombus. These factors might be helpful for the surgeon's determination to improve therapeutic efficacy.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionsupporting

confidence: 52%

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Surgical treatment of renal cell carcinoma: Can morphological features of inferior vena cava tumor thrombus on computed tomography or magnetic resonance imaging be a prognostic factor?

et al. 2017

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“…Plasma fibrinogen levels were measured in 4 studies by a functional method based on the Clauss assay [11, 15–17]; fibrinogen tests were included in the coagulation panel among the preoperative workups in one study [19]; and, in the rest of the two studies, no comments were made on this point [10, 17]. Differences in the cut-off value for high plasma fibrinogen were observed among the studies.…”

Section: Resultsmentioning

confidence: 99%

Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis

Tian

Hong

Jing

et al. 2017

BioMed Research International

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Background. Although numerous studies have shown that plasma fibrinogen is linked to renal cell carcinoma (RCC) risk, the consistency and magnitude of the effect of plasma fibrinogen are unclear. The aim of the study was to explore the association between plasma fibrinogen and RCC prognosis. Methods. An electronic search of Embase, PubMed/MEDLINE, and the Cochrane databases was performed to identify relevant studies published prior to June 1, 2016. Results. A total of 3744 patients with RCC from 7 published studies were included in the meta-analysis. The prognostic and clinical relevance of plasma fibrinogen are evaluated in RCC patients. Statistical significance of the combined hazard ratio (HR) was detected for overall survival, cancer-specific survival, and disease-free survival. Our pooled results showed that elevated plasma fibrinogen was significantly associated with clinical stage and Fuhrman grading. The level of plasma fibrinogen was not found to be associated with tumor type and gender. Conclusions. Elevated plasma fibrinogen is a strong indicator of poorer prognosis of patients with RCC, whereas the plasma fibrinogen is not significantly associated with tumor type. Therefore, plasma fibrinogen could be used in patients with RCC for risk stratification and decision providing a proper therapeutic strategy.

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Validation of the diagnostic and prognostic relevance of serum MMP-7 levels in renal cell cancer by using a novel automated fluorescent immunoassay method

et al. 2016

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Renal cell carcinoma and tumour thrombus in the inferior vena cava: clinical outcome of 98 consecutive patients and the prognostic value of preoperative parameters

Abstract: The surgical treatment of RCC with tumour thrombus in the RV or IVC has favourable results. Extended thrombus disease requires multidisciplinary approach. High serum potassium levels and platelet counts are associated with reduced DSS.

Cited by 17 publications

References 26 publications

Surgical treatment of renal cell carcinoma: Can morphological features of inferior vena cava tumor thrombus on computed tomography or magnetic resonance imaging be a prognostic factor?

Surgical treatment of renal cell carcinoma: Can morphological features of inferior vena cava tumor thrombus on computed tomography or magnetic resonance imaging be a prognostic factor?

Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis

Validation of the diagnostic and prognostic relevance of serum MMP-7 levels in renal cell cancer by using a novel automated fluorescent immunoassay method

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