Renal Carcinoma and Polycystic Disease

Are Malignancies Increased in Uremia?

“…These patients have thus been exposed to a longer period of uremia than those with other diagnoses such as glomerulonephritis, nephrosclerosis, or diabetes. An increased incidence of renal, bladder, and other cancers have been reported in patients with polycystic kidney disease and pyelonephritis (analgesic abuse), possi bly apart from uremia [14][15][16], The relationship between the primary disease, uremia and renal and bladder carci noma in these particular patients thus becomes very complex. However, only 1 case of renal cancer was observed in the patients with polycystic kidney disease, and all reports cited above exclude cases where the malignancy caused renal failure.…”

Bilateral Renal Cell Carcinoma in Autosomal Dominant Polycystic Kidney Disease

“…This case illustrates the diagnostic dilemma faced when considering carcinoma in patients with ADPKD. Asymmetry in size and shape of the kidneys, a palpable mass, and hematuria can be associated with ADPKD and RCC, both separately or in combination [4], With the increased survival rates of patients with ADPKD un dergoing dialysis and renal transplantation, carcinoma must be carefully considered in the differential diagnosis when complex cysts are noted within the kidney on stud ies performed for symptoms or during screening.…”

Management of Renal Cystic Disorders

“…Pain in association with fever, weight loss, anemia and a striking change in the configuration of the kidney must raise the suspicion of renal malignancy. The most reliable diagnostic signs of malignancy are speckled calcifications within the parenchyma of the kidney (40), the appearance of a solid mass structure by sonography (41), the appearance of tissue with a high computed tomography (CT) number (42,43) and a typical arteriogram appearance upon infusion of urographic contrast material into the renal artery (44)(45)(46)(47).…”