Renal Biopsy Changes With Pheochromocytoma

Silva, Thomas F.; Sommers, Sheldon C.

doi:10.1097/00000441-195812000-00003

Cited by 12 publications

(1 citation statement)

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“…Furthermore, it has been long known that pheochromo cytoma is associated with juxtaglomerular cell hyperplasia [13]. The fact that hyperreninemia and hypokalemia were promptly reversed by (1-blockade and were sustained fol lowing tumor resection further speaks against significant vascular disease of the kidney and supports the concept that norepinephrine-induced renal renin release was the princi pal mechanism at work.…”

Section: Commentmentioning

confidence: 87%

Hyperreninemia and Secondary Hyperaldosteronism in a Patient with Pheochromocytoma and von Hippel-Lindau Disease

Lenz

Thiede²,

Nussberger³

et al. 1992

Nephron

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In a 21-year-old Caucasian woman with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of captopril further enhanced renin secretion, while her blood pressure improved. The patient became normokalemic following tumor removal, and her blood pressure decreased to normal levels with reestablishment of normal circadian blood pressure rhythm. This case demonstrates that, in the absence of renovascular or malignant hypertension, pheochromocytoma can be the underlying cause for the clinical syndrome of hypertension associated with severe hypokalemia and hyperreninemic hyperaldosteronism.

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Section: Commentmentioning

confidence: 87%