Renal biomarkers in domestic species

Hokamp, Jessica A.; Nabity, Mary B.

doi:10.1111/vcp.12333

Cited by 132 publications

(191 citation statements)

References 225 publications

(487 reference statements)

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“…We measured serum SDMA as a noninvasive means to assess GFR. SDMA is a small molecule that is primarily eliminated by renal excretion and can serve as an endogenous marker of GFR . Increases in SDMA are used for early identification of decreased renal function in dogs and cats with kidney disease .…”

Section: Discussionmentioning

confidence: 99%

“…SDMA is a small molecule that is primarily eliminated by renal excretion and can serve as an endogenous marker of GFR . Increases in SDMA are used for early identification of decreased renal function in dogs and cats with kidney disease . Both SDMA and serum creatinine concentrations were significantly higher in Greyhounds compared to non‐Greyhounds.…”

Section: Discussionmentioning

confidence: 99%

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The Renin‐Angiotensin‐Aldosterone System in Greyhounds and Non‐Greyhound Dogs

Martinez

Kellogg

Iazbik

et al. 2017

Veterinary Internal Medicne

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BackgroundThe renin‐angiotensin‐aldosterone system (RAAS) regulates blood pressure, electrolyte homeostasis, and renal function. Blood pressure, serum sodium concentrations, and urinary albumin excretion are higher in Greyhounds than other purebred and mixed‐breed dogs.HypothesisAlterations in the RAAS in Greyhounds are associated with hemodynamic and clinicopathologic differences observed in the breed.AnimalsClinically healthy Greyhound and non‐Greyhound dogs consecutively enrolled as blood donors (n = 20/group).MethodsProspective study. Standard chemical analysis was performed on serum and urine. Serum angiotensin‐converting enzyme (ACE) activity was determined by fluorometric assay. All other RAAS hormones were determined by radioimmunoassay. Symmetric dimethylarginine (SDMA) was measured by immunoassay. Measurements were compared to blood pressure and urine albumin concentration. Data are presented as mean ± SD or median, range.ResultsSerum creatinine (1.5 ± 0.2 vs 1.0 ± 0.1 mg/dL, P < .001), sodium (149, 147–152 vs 148, 146–150 mEq/L, P = .017), and SDMA (16.1 ± 2.9 vs 12.2 ± 1.8 μg/dL, P < .001) were significantly higher in Greyhounds versus non‐Greyhounds, respectively. Plasma renin activity (0.69, 0.10–1.93 vs 0.65, 0.27–2.93 ng/mL/h, P = .60) and ACE activity (4.5, 2.1–8.5 vs 4.6, 2.1–11.4 activity/mL; P = .77) were similar between groups and did not correlate with higher systolic pressures and albuminuria in Greyhounds. Plasma aldosterone concentration was significantly lower in Greyhounds versus non‐Greyhounds (11, 11–52 vs 15, 11–56 pg/mL, respectively, P = .002).Conclusions and clinical importanceBasal RAAS activation did not differ between healthy Greyhounds and non‐Greyhounds. Lower aldosterone concentration in Greyhounds is an appropriate physiologic response to higher serum sodium concentration and blood pressure, suggesting that angiotensin II effects in the renal tubule predominate over those of aldosterone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Renin‐Angiotensin‐Aldosterone System in Greyhounds and Non‐Greyhound Dogs

Martinez

Kellogg

Iazbik

et al. 2017

Veterinary Internal Medicne

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“…4,24,25,26 Similar efforts are underway in veterinary medicine and show great promise. [28][29][30][31][32][33][34][35][36] (See also, Yerramilli in this issue) An AKI biomarker should be detectable in urine and/or plasma such that it can be assessed routinely and serve as an indicator of kidney function or dysfunction or response to injury. The ideal marker should reflect kidney specific events, be unique and specific to the kidney, and reflect very early and potentially sustained phases of the pathogenesis and repair processes.…”

Section: Identification Of Progressive Ckd: the Search For Active Injmentioning

confidence: 99%

Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Cowgill

Polzin

Elliott

et al. 2016

Veterinary Clinics of North America: Small Animal Practice

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“…Indeed, compared with the PCa group, the Non-PCa group had larger average prostate volumes (57.67 vs 53.28, p=0.018, Table 1), which might reflect more serious lower urinary tract symptoms, causing renal function impairment at a certain level. Current conventional assays show a positive correlation between blood creatinine and kidney damage [21]. Moreover, it can be concluded that PSA plays a more significant diagnostic role in patients with 10–50 ng/mL PSA, while f/t PSA and PSAD show obvious differences between the PCa and Non-PCa groups for individuals with 4–10 ng/mL PSA.…”

Section: Discussionmentioning

confidence: 99%

Risk assessment models to evaluate the necessity of prostate biopsies in North Chinese patients with 4-50 ng/mL PSA

et al. 2016

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BackgroundProstate-specific antigen (PSA) is widely used for prostate cancer screening, but low specificity results in high false positive rates of prostate biopsies.ObjectiveTo develop new risk assessment models to overcome the diagnostic limitation of PSA and reduce unnecessary prostate biopsies in North Chinese patients with 4–50 ng/mL PSA.MethodsA total of 702 patients in seven hospitals with 4–10 and 10–50 ng/mL PSA, respectively, who had undergone transrectal ultrasound-guided prostate biopsies, were assessed. Analysis-modeling stage for several clinical indexes related to prostate cancer and renal function was carried out. Multiple logistic regression analyses were used to develop new risk assessment models of prostate cancer for both PSA level ranges 4-10 and 10-50 ng/mL. External validation stage of the new models was performed to assess the necessity of biopsy.ResultsThe new models for both PSA ranges performed significantly better than PSA for detecting prostate cancers. Both models showed higher areas under the curves (0.937 and 0.873, respectively) compared with PSA alone (0.624 and 0.595), at pre-determined cut-off values of 0.1067 and 0.6183, respectively. Patients above the cut-off values were recommended for immediate biopsy, while the others were actively observed. External validation of the models showed significantly increased detection rates for prostate cancer (4-10 ng/mL group, 39.29% vs 17.79%, p=0.006; 10-50 ng/mL group, 71.83% vs 50.0%, p=0.015).ConclusionsWe developed risk assessment models for North Chinese patients with 4–50 ng/mL PSA to reduce unnecessary prostate biopsies and increase the detection rate of prostate cancer.

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Renal biomarkers in domestic species

Cited by 132 publications

References 225 publications

The Renin‐Angiotensin‐Aldosterone System in Greyhounds and Non‐Greyhound Dogs

The Renin‐Angiotensin‐Aldosterone System in Greyhounds and Non‐Greyhound Dogs

Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Risk assessment models to evaluate the necessity of prostate biopsies in North Chinese patients with 4-50 ng/mL PSA

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