Renal artery stenosis: detection and quantification with spiral CT angiography versus optimized digital subtraction angiography.

Kaatee, R.; Beek, F. J. A.; Lange, Eduard E. de; Leeuwen, Maarten S. van; Smits, Henk F.M.; Ven, P. J. G. Van Der; Beutler, Jaap J.; Mali, W. P. T. M.

doi:10.1148/radiology.205.1.9314973

Cited by 144 publications

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“…This was a rather exploratory study designed to evaluate a spinal cord compression model and compare two imaging techniques. Reports suggest agreement between CT angiography and digital subtraction angiography are very high (r > 90%) for evaluation of vascular components (Link et al 1996, Kaatee et al 1997. Despite the relative small study population, DSV and CT venography consistently demonstrated changes in IVVP morphology during experimental spinal cord compression.…”

Section: Digital Subtraction Venographymentioning

confidence: 91%

Effects of artificially induced spinal cord compression on the canine cervical internal vertebral venous plexus: comparative evaluation of computed tomographic venography and digital subtraction venography

Gómez

Lanz²,

Jones³

et al. 2008

Arch. med. vet.

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Effects of artificially induced spinal cord compression on the canine cervical internal vertebral venous plexus: comparative evaluation of computed tomographic venography and digital subtraction venographyEfectos de la compresión de la médula espinal inducida artificialmente sobre el plexo venoso vertebral interno cervical en el perro: evaluación comparativa mediante venografía por tomografía computarizada y venografía por substracción digital RESUMENEl plexo venoso vertebral interno (PVVI) es una red vascular localizada a lo largo del canal vertebral. El presente estudio fue diseñado para evaluar variaciones en la morfología del PVVI cervical bajo condiciones de compresión aguda de la médula espinal en perros. Una compresión medular experimental fue inducida en once perros adultos al nivel de C3/4 utilizando una técnica modificada de catéter de angioplastia con balón. Los perros fueron evaluados antes, durante y posterior a la compresión medular utilizando para ello venografía intraósea por substracción digital (VSD) y venografía por tomografía computarizada (TC). La VSD mostró pérdida manifiesta e inmediata de opacificación del PVVI cervical en el sitio de la compresión. La venografía por TC también evidenció pérdida de llenado del PVVI cervical con medio de contraste en las áreas comprimidas por el balón de angioplastia. La VSD también mostró cambios hemodinámicos del PVVI y sus ramas colaterales durante la compresión. Durante la postcompresión las imágenes de la VSD y la venografía por TC revelaron que algunos perros presentaban pérdida de llenado con medio de contraste del PVVI cervical en el área previamente comprimida. Los resultados de este estudio muestran que la compresión medular experimental en perros induce alteraciones locales inmediatas en la morfología venosa dentro del canal vertebral afectado.

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Section: Digital Subtraction Venographymentioning

confidence: 91%

Effects of artificially induced spinal cord compression on the canine cervical internal vertebral venous plexus: comparative evaluation of computed tomographic venography and digital subtraction venography

Gómez

Lanz²,

Jones³

et al. 2008

Arch. med. vet.

View full text Add to dashboard Cite

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“…[5][6][7][8] The diagnostic role of conventional angiography continues to diminish as noninvasive CT and MR angiography develop. [4,6,8] Parameters that favor noninvasive vascular imaging include patient's comfort, duration of the examination, reduced complication rate [9,10] and diminished cost. However, conventional angiography still has superior resolution for the evaluation of small vessels and offers the option of simultaneous therapeutic interventions such as percutaneous revascularization by balloon angioplasty and/or stenting.…”

Section: Introductionmentioning

confidence: 99%

Imaging Modalities for Renal Artery Stenosis in Suspected Renovascular Hypertension: Prospective Intraindividual Comparison of Color Doppler US, CT Angiography, GD-Enhanced MR Angiography, and Digital Substraction Angiography

et al. 2007

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The aim of the study was to evaluate the diagnostic accuracy of Color Doppler US, CT Angiography (CTA), and GDenhanced MR Angiography (MRA) compared with digital subtraction angiography (DSA) for the detection of renal artery stenosis in patients with clinically suspected renovascular hypertension. Fifty-eight patients with suspected renovascular hypertension were enrolled in the study. All patients underwent Color Doppler US, CTA and GD-enhanced MRA. DSA was the gold standard method for the number of renal arteries, existence and degree of stenosis, or evidence of fibromuscular dysplasia. DSA depicted 132 renal arteries, 16 stenoses, and 4 arteries with fibromuscular dysplasia. Color Doppler US failed to detect 1 main and 14 polar arteries. CTA depicted all main renal arteries and 7/16 polar arteries, but failed to detect stenosis in two accessory vessels. Likewise, MRA did not detect stenotic accessory renal arteries, depicted 9/16 polar renal arteries, but missed two main renal arteries. All methods depicted the four main renal arteries with fibromuscular dysplasia. The overall sensitivity, specificity, and positive and negative predictive accuracy were 75%, 89.6%, 60% and 94.6%, respectively, for color Doppler US; 94%, 93%, 71%, and 99%, respectively, for CTA; and 90%, 94.1%, 75%, and 98%, respectively, for GD-enhanced MRA. CTA and GD-enhanced MRA have comparable and satisfactory results with respect to the negative predictive accuracy of the suspected renal artery stenosis. The concept of an imaging algorithm including US as screening test when appropriate and CTA or MRA as the second step-procedure is suggested. Therefore, DSA may be reserved for cases with major discrepancies or therapeutic interventions.

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“…[3][4][5][6] Magnetic resonance (MR) angiography (MRA) and computed tomography angiography are oriented toward depicting anatomy rather than tissue injury. 7,8 Radionuclide captopril renography has not been widely accepted 9 because of its limited accuracy in the presence of bilateral disease 10 or therapy with ACE inhibitors. 11 Inhibiting the activity of the AT 1 R with angiotensin receptor blockers or ACE inhibitors, on the other hand, is widely adapted by clinicians to protect the kidney from renal injury.…”

mentioning

confidence: 99%

Positron-Emission Tomography Imaging of the Angiotensin II Subtype 1 Receptor in Swine Renal Artery Stenosis

Xia¹,

Seckin²,

Xiang³

et al. 2008

Hypertension

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Abstract-The angiotensin II subtype 1 receptor (AT 1 R) has been linked to the development and progression of renovascular hypertension. In this study we applied a pig model of renovascular hypertension to investigate the AT 1 R in vivo with positron-emission tomography (PET) and in vitro with quantitative autoradiography. AT 1 R PET measurements were performed with the radioligand [ 11 C]KR31173 in 11 control pigs and in 13 pigs with hemodynamically significant renal artery stenosis; 4 were treated with lisinopril for 2 weeks before PET imaging. The radioligand impulse response function was calculated by deconvolution analysis of the renal time-activity curves. Key Words: positron-emission tomography Ⅲ angiotensin AT 1 receptor Ⅲ swine Ⅲ animal models Ⅲ renovascular hypertension R enovascular hypertension is the most common type of secondary hypertension that occurs in 2 to 4 million people in the United States. The renin-angiotensin system and its component, the angiotensin II subtype 1 receptor (AT 1 R), have been tightly linked to the development and progression of renovascular hypertension (RVH), but experimental mechanistic evidence for regulation of the AT 1 R has not been established in vivo. Antagonists against the angiotensin-converting enzyme (ACE; ACE inhibitors) or the AT 1 R (angiotensin receptor blockers) continue to play a key role in the therapy of renal hypertension and other kidney diseases. 1 Both drugs represent a "doubleedged sword," because they may deactivate regulatory effects of the renin-angiotensin system and the AT 1 R and trigger irreversible renal damage. 2 The complexity of the management of RVH raises a pressing need for an in vivo imaging technique that cannot only demonstrate reduced blood flow to the organ but also detect and monitor renal ischemia at the molecular level. [3][4][5][6] Magnetic resonance (MR) angiography (MRA) and computed tomography angiography are oriented toward depicting anatomy rather than tissue injury. 7,8 Radionuclide captopril renography has not been widely accepted 9 because of its limited accuracy in the presence of bilateral disease 10 or therapy with ACE inhibitors. 11 Inhibiting the activity of the AT 1 R with angiotensin receptor blockers or ACE inhibitors, on the other hand, is widely adapted by clinicians to protect the kidney from renal injury. [12][13][14][15][16] Probing molecular changes is expected to assist diagnosis and support prediction and evaluation of treatment success. We have identified the AT 1 R as a significant molecular imaging target because of its intricate involvement in the many aspects of renal physiology and pathology, [17][18][19] particularly in acute, subacute, and chronic complications of renal ischemia. 20,21 The AT 1 R is a key injury response protein because its continuing activation leads to stimulation of the extracellular matrix, 22 collagen deposition, glomerular remodeling, 23 inflammation, 24 apoptosis, 25 generation of oxygen species, and cell cycle arrest. 26 To this end, our group has synthesized several ...

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Renal artery stenosis: detection and quantification with spiral CT angiography versus optimized digital subtraction angiography.

Abstract: Spiral CT angiography enabled accurate assessment of renal artery stenosis in patients with possible renovascular hypertension and may assist in selecting patients for interventional treatment.

Cited by 144 publications

References 0 publications

Effects of artificially induced spinal cord compression on the canine cervical internal vertebral venous plexus: comparative evaluation of computed tomographic venography and digital subtraction venography

Effects of artificially induced spinal cord compression on the canine cervical internal vertebral venous plexus: comparative evaluation of computed tomographic venography and digital subtraction venography

Imaging Modalities for Renal Artery Stenosis in Suspected Renovascular Hypertension: Prospective Intraindividual Comparison of Color Doppler US, CT Angiography, GD-Enhanced MR Angiography, and Digital Substraction Angiography

Positron-Emission Tomography Imaging of the Angiotensin II Subtype 1 Receptor in Swine Renal Artery Stenosis

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