Renal angiotensin II receptor regulation and reninangiotensin system inhibition in one-kidney, one clip hypertensive rats

Amiri, Farhad; Haddad, Georges E.; García, Raúl

doi:10.1097/00004872-199917020-00013

Cited by 17 publications

(19 citation statements)

References 25 publications

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“…In an additional set of experiments (n ϭ 6), we measured the plasma renin activity, which was markedly increased 4 weeks after renal artery clipping (3.9 Ϯ 1.3 v 1.8 Ϯ 0.33 ng/mL/h in sham-operated rats) and returned to basal values much latter (10 to 12 weeks post-clip). Similar results have been reported in the one-kidney, one-clip hypertensive model by Amiri et al 27 ) Angiotensin II is a powerful angiogenic substance in vivo and in vitro. 12 Munzenmaier and Greene 28 reported that subpressor angiotensin II infusion initiates angiogenesis in the rat cremaster muscle.…”

Section: Microvasculature and The Rassupporting

confidence: 89%

Coronary microvasculature alteration in hypertensive rats. Effect of treatment with a diuretic and an ACE inhibitor

Lévy

Duriez

Samuel

2001

American Journal of Hypertension

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The development of hypertension is accompanied by rarefaction of arterioles and capillaries in both animal models and humans. Although many studies have examined the effects of antihypertensive therapies on hemodynamics, cardiac hypertrophy, and large vessel structure, the question of whether changes in microvascular density induced by hypertension can be restored by pharmacologic treatment has yet to be answered.We report a series of experiments performed in rats with renovascular hypertension induced by unilateral nephrectomy and renal artery stenosis (Goldblatt one-kidney, one-clip model). Animals were treated for 4 weeks, after renal artery clipping, either with an angiotensin converting enzyme inhibitor (perindopril [PER], 0.76 mg/kg/day), or with an indol derivative diuretic with specific vascular properties (indapamide [IDP], 0.24 mg/kg/day) or with the combination of both drugs at the same doses as during monotherapy. Coronary microvessel densities (arterioles and capillaries) were evaluated by double immunolabeling in nonserial cryostat sections of the left ventricular inner myocardium.After 4 weeks of hypertension (mean arterial pressure, 174 Ϯ 11 v 124 Ϯ 5 mm Hg in normotensive (NT) controls, P Ͻ .01), cardiac hypertrophy (ϩ59%, P Ͻ .001) was associated with a significant increase in myocardial arteriolar density (ϩ27%, P Ͻ .01), and a decrease in capillary density (Ϫ12%, P Ͻ .05).Treatment with PER prevented the increase in arterial pressure, heart weight, and arteriolar density, but did not significantly affect the low coronary capillary density in comparison with that measured in untreated hypertensive (HT) rats.Treatment with IDP preserved normal capillary myocardial density but did not significantly lower the blood pressure (BP) (169 Ϯ 9 mm Hg) and only slightly reduced the cardiac ventricular hypertrophy: Ϫ14% v untreated HT (P Ͻ .05) and ϩ37% v NT (P Ͻ .01). In the same way, IDP normalized the left ventricular capillary density in spontaneously HT rats (ϩ18% v untreated rats, P Ͻ .01).The combination of both drugs, PER and IDP, at the same low doses as during monotherapy, resulted in normal levels of arterial pressure and complete normalization of cardiac hypertrophy and arteriolar and capillary myocardial densities.In conclusion, the results observed after PER suggest that blockade of the renin-angiotensin system could inhibit large coronary vessel growth but minimally affects the capillary density despite complete normalization of BP. Indapamide could have beneficial effect on myocardial capillary density. The combination of IDP and PER has additional effects and prevents the increase in BP and cardiac weight, and reverses microvascular rarefaction, specifically arteriolar and capillary densities. Am J Hypertens 2001;14:7-13 © 2001 American Journal of Hypertension, Ltd. Key Words: Angiogenesis, ACE inhibitors, diuretics.A s early as 1933, Ruedemann 1 reported a decrease in the number of small vessels in the conjunctiva of patients with essential hypertension. Hutchins and Darnell 2 first des...

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Section: Microvasculature and The Rassupporting

confidence: 89%

Coronary microvasculature alteration in hypertensive rats. Effect of treatment with a diuretic and an ACE inhibitor

Lévy

Duriez

Samuel

2001

American Journal of Hypertension

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“…Studies in two-kidney, oneclip Goldblatt hypertensive rats demonstrated that glomerular AT1 receptors were decreased by 2 weeks after clipping, but vascular receptors were not decreased until 16 weeks (Amiri and Garcia, 1997). However, glomerular AT1 receptor density was not increased in the onekidney-one-clip model, although vascular AT1 receptor density was increased (Amiri et al, 1999). In the Ang II-infused rat model of hypertension, total kidney AT1 receptor mRNA levels and protein levels were not suppressed but were maintained by 2 weeks of Ang II infusion sufficient to cause marked hypertension (HarrisonBernard et al, 1999).…”

Section: Angiotensin II Receptorsmentioning

confidence: 98%

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

et al. 2007

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“…The AT1R is responsible for the classical actions of Ang II such as vasoconstriction, aldosterone release from the adrenal zona glomerulosa, salt retention in the renal tubules, and stimulation of the sympathetic nervous system. AT2R plays an important role in the growth, differentiation, and regeneration of neuronal tissue [132,133].…”

Section: Ang II Receptorsmentioning

confidence: 99%

The Renin Angiotensin System and the Metabolic Syndrome~!2010-02-12~!2010-04-19~!2010-06-25~!

Wang¹,

Li²,

Takahashi³

2010

TOHYPERJ

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Renal angiotensin II receptor regulation and reninangiotensin system inhibition in one-kidney, one clip hypertensive rats

Cited by 17 publications

References 25 publications

Coronary microvasculature alteration in hypertensive rats. Effect of treatment with a diuretic and an ACE inhibitor

Coronary microvasculature alteration in hypertensive rats. Effect of treatment with a diuretic and an ACE inhibitor

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

The Renin Angiotensin System and the Metabolic Syndrome~!2010-02-12~!2010-04-19~!2010-06-25~!

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