Renal and immunologic markers for chloralkali workers with low exposure to mercury vapor

Ellingsen, Dag G.; Efskind, Jon; Berg, K. J.; Gaarder, Per Ivar; Thomassen, Yngvar

doi:10.5271/sjweh.564

Cited by 48 publications

(32 citation statements)

References 32 publications

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“…Generally, transient immunologic changes may occur after exposure to mercuric chloride. Only one epidemiologic study has reported an elevation of anti-GBM however (3), and elevation is contradicted by several nonpositive investigations (4,(8)(9)(10)(13)(14)(15).…”

mentioning

confidence: 83%

“…Selenium may also protect the proximal tubule cells in patients receiving cis-platinum (23). A previous epidemiologic study of chloralkali workers suggested that selenium status may modify the effect of exposure to mercury vapor on U-NAG activity (10). The human kidney is rich in selenium, and selenium-dependent glutathione peroxidase (GSHpx) in plasma is, to a large extent, synthesized in the proximal tubule cells (24)(25)(26).…”

mentioning

confidence: 99%

“…Increased U-NAG activity in chloralkali workers has been associated with exposure levels corresponding to U-Hg of about 5 nmol/ mmol creatinine (10).…”

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confidence: 99%

“…Cross-sectional studies of workers during ongoing exposure to mercury vapor have shown an elevated activity of the kidney proximal tubular cell enzyme N-acetyl-β-D-glucosaminidase in urine (U-NAG) or associations between U-NAG and the mercury concentration in urine (U-Hg) (4,5,(7)(8)(9)(10). Increased U-NAG activity in chloralkali workers has been associated with exposure levels corresponding to U-Hg of about 5 nmol/ mmol creatinine (10).…”

mentioning

confidence: 99%

“…Most of the participants had also been examined before the exposure ceased, as their concentration of U-NAG was increased (10). Thus the primary aim of this study was to assess the kidney function and to study a potential reversibility of selected biomarkers of renal toxicity.…”

mentioning

confidence: 99%

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Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Efskind¹,

Ellingsen²,

Hartman³

et al. 2006

Scand J Work Environ Health

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confidence: 83%

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confidence: 99%

“…Increased U-NAG activity in chloralkali workers has been associated with exposure levels corresponding to U-Hg of about 5 nmol/ mmol creatinine (10).…”

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Efskind¹,

Ellingsen²,

Hartman³

et al. 2006

Scand J Work Environ Health

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Effects of low mercury vapour exposure on the thyroid function in chloralkali workers

et al. 2000

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Forty‐seven chloralkali workers exposed to mercury vapour for an average of 13.3 years were compared with 47 referents matched for age in a cross‐sectional study of thyroid function. The mean urinary mercury concentration in the exposed workers was low compared with other studies of chloralkali workers: 5.9 nmol mmol−1 creatinine (range 1.1–16.8) vs 1.3 nmol mmol−1 creatinine (range 0.2–5.0) in the reference group. The median serum concentration of reverse triiodothyronine (rT3) was statistically significantly higher in the exposed subjects compared with the referents (268 pmol l−1 and range 161–422 vs 240 pmol l−1 and range 129–352; P = 0.009). The difference between the exposed subjects and the referents was most pronounced in the highest exposed sub‐groups. The free thyroxine (T4)/free T3 ratio was also higher in the highest exposed subgroups compared with the referents. The median serum concentration of tumour necrosis factor alpha (TNF‐α) was lower in the exposed subjects (7.3 pg ml−1 and range 4.4–69.7 vs 8.0 pg ml−1 and range 6.0–34.6; P = 0.004). Exposed subjects with the lowest urinary iodine (<67.8 nmol mmol−1 Cr) had higher serum concentrations of reverse T3 and a higher free T4/free T3ratio than the other subjects, suggesting that a low concentration of iodine in urine may be a risk factor for increased serum concentrations of reverse T3 and the free T4/free T3 ratio in subjects exposed occupationally to mercury vapour. The study could indicate a slight effect of low mercury vapour exposure on the function of the enzyme type I iodothyronine deiodinase, possibly modified by comparatively low urinary iodine concentrations. Copyright © 2000 John Wiley & Sons, Ltd.

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Quecksilber und seine anorganischen Verbindungen, Addendum [BAT Value Documentation in German language, 2006]

Bolt¹,

Meyer-Baron²,

Reuter³

et al. 2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte), Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) und Biologische Leitwerte (BLW) , 13. Lieferung, Ausgabe 2006 Der Artikel enthält folgende Kapitel: Reevaluierung der BAT‐Werte Metabolismus und Toxikokinetik Belastung und Beanspruchung Nephrotoxische Effekte bei beruflicher Exposition gegen anorganisches Quecksilber

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Renal and immunologic markers for chloralkali workers with low exposure to mercury vapor

Cited by 48 publications

References 32 publications

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Renal function of chloralkali workers after the cessation of exposure to mercury vapor

Effects of low mercury vapour exposure on the thyroid function in chloralkali workers

Quecksilber und seine anorganischen Verbindungen, Addendum [BAT Value Documentation in German language, 2006]

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