Renal allografts in plasma cell myeloma hematopoietic cell graft recipients: on the verge of an explosion?

Nayak, Lalitha; Lazarus, Hillard M.

doi:10.1038/bmt.2012.111

Cited by 12 publications

(6 citation statements)

References 57 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous retrospective studies describe the efficiency of hematopoietic cell transplant even in advanced renal failure that requires kidney transplantation. Regression of renal damage after 4–5 months from ASCT has been also reported (23).…”

Section: Hematopoietic Cell Transplant (Hct)mentioning

confidence: 85%

“…In patients with PCD-related chronic nephropathy, the severity of renal dysfunction does not affect the response to chemotherapy. However, autologous stem cell transplant induces complete remission and longer survival than chemotherapy (23). Numerous retrospective studies describe the efficiency of hematopoietic cell transplant even in advanced renal failure that requires kidney transplantation.…”

Section: Hematopoietic Cell Transplant (Hct)mentioning

confidence: 99%

See 1 more Smart Citation

Hematopoietic Cell and Renal Transplantation in Plasma Cell Dyscrasia Patients

et al. 2016

View full text Add to dashboard Cite

Gammopathies, multiple myeloma, and amyloidosis are plasma dyscrasias characterized by clonal proliferation and immunoglobulin overproduction. Renal impairment is the most common and serious complication with an incidence of 20-30% patients at the diagnosis. Kidney transplant has not been considered feasible in the presence of plasma dyscrasias because the immunosuppressive therapy may increase the risk of neoplasia progression, and paraproteins may affect the graft. However, recent advances in clinical management of multiple myeloma and other gammopathies allow considering kidney transplant as a possible alternative to dialysis. Numerous evidence indicates the direct relationship between hematological remission and renal function restoring. The combination of kidney and hematopoietic cell transplant has been reported as a promising approach to reestablish end-organ function and effectively treat the underlying disease. This review describes current protocols used to perform kidney transplantation in patients with plasma dyscrasias.

show abstract

Section: Hematopoietic Cell Transplant (Hct)mentioning

confidence: 85%

Section: Hematopoietic Cell Transplant (Hct)mentioning

confidence: 99%

Hematopoietic Cell and Renal Transplantation in Plasma Cell Dyscrasia Patients

et al. 2016

View full text Add to dashboard Cite

show abstract

“…These cases demonstrate that renal transplantation in PCD patients may be considered as a therapeutic option, especially in dialysis‐dependent younger patients with a good performance status and if sustained remission can be achieved. It has been demonstrated that this procedure improves the quality of life and even produces higher survival rates than dialysis . Furthermore, by increasing renal clearance, better tolerance to subsequent treatments can be achieved.…”

Section: Discussionmentioning

confidence: 99%

Renal transplant in plasma cell dyscrasias with lenalidomide treatment after autologous stem cell transplantation

et al. 2013

View full text Add to dashboard Cite

Plasma cell dyscrasias (PCD) are a spectrum of diseases characterized by clonal proliferation of plasma cells secreting a monoclonal immunoglobulin. Although considered an incurable disease, a combination of autologous stem cell transplant with novel therapies, including lenalidomide, has improved the overall and progression-free survival of these patients. Renal impairment is an important complication of the disease that, in some cases, progresses to end-stage renal disease. Due to the characteristics of PCD, traditionally these patients have not been candidates for renal transplantation. However, treatment improvement allows a reconsideration of this perception, especially in younger patients with good performance status and treatment response. We report two cases of patients diagnosed with PCD undergoing renal transplantation after autologous stem cell transplantation, both cases under treatment with lenalidomide. We also report their perioperative management and their outcome.

show abstract

“…One of the treatment methods for MM patients involved with RI is renal transplantation, which can be used as a treatment alternative for these patients, due to the increasing number of patients. The results of a study which was conducted on 166 patients in 2013 showed that the risks of immunosuppression should be considered in those who received ASCT and kidney allograft transplants, and eventually 26 of them survived without the need for dialysis (10,75).…”

Section: Renal Transplantationmentioning

confidence: 99%

New Methods in Treatment of Renal Failure in Patients with Multiple Myeloma : A Review with Immunological Approach

Saeedi-Boroujeni¹,

Iranparast²,

Shirani³

2017

ME-JFM

View full text Add to dashboard Cite

Multiple myeloma (MM), as one of a variety of autoimmune diseases, affects the immune system and, on the other hand, is considered to be a hematologic impairment. One of the most common and important complications of MM is renal impairment (RI), which is associated with an increase in serum Cr levels. Although RI is one of the major complications of MM, the routine therapies for MM patients practically lack acceptable efficacy for the improvement of RI patients, and as a result, RI remains a deadly disease with high mortality rate and very bad prognosis; therefore, new treatments have been proposed for the improvement of nephropathy in patients with MM, and extensive research is ongoing in various phases, including clinical trials. Attempts were made in this study to review common and advanced treatments (immunotherapy, cell therapy, new therapies based on genetic engineering) in these patients and to consider this disease from an immunological viewpoint.

show abstract

Renal allografts in plasma cell myeloma hematopoietic cell graft recipients: on the verge of an explosion?

Cited by 12 publications

References 57 publications

Hematopoietic Cell and Renal Transplantation in Plasma Cell Dyscrasia Patients

Hematopoietic Cell and Renal Transplantation in Plasma Cell Dyscrasia Patients

Renal transplant in plasma cell dyscrasias with lenalidomide treatment after autologous stem cell transplantation

New Methods in Treatment of Renal Failure in Patients with Multiple Myeloma : A Review with Immunological Approach

Contact Info

Product

Resources

About