Renal adenocarcinoma-associated erythrocytosis in a cat: Clinicopathological features and immunohistochemical results

Abstract

This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-yearold cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat's clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells.

Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study

“…To the authors' knowledge, this is the first case series to investigate the presenting signs and clinical outcomes of cats with RC undergoing nephrectomy. Study demographics echoed the current body of literature: cats were middle‐aged to older with no breed or sex predilection 1–5,10,22,23 . Clinical signs were nonspecific with weight loss, hyporexia, and vomiting being most common.…”

“…Feline RCC has mainly been reported in middle-aged to older cats. [1][2][3][4][5]10,22,23 Breed and sex predispositions have not been reported. 3,4 Feline RCC is typically unilateral, with left and right kidneys affected at similar rates.…”

“…3,4 Paraneoplastic polycythemia has been reported and generally resolves following nephrectomy. 6,[22][23][24][25][26] RCC has also been documented in cats with concurrent polycystic kidney disease (PKD) and those undergoing cyclosporine therapy for renal transplantation. 9,10 In the most comprehensive report of non-lymphomatous primary renal tumours in cats, 19 cases were described, 13 of which were diagnosed as RCC.…”

Reporte de caso clínico: adenocarcinoma renal con metástasis a cavidad abdominal

“…Para el diagnóstico definitivo es necesario realizar biopsia de la masa por medio de laparotomía, o percutánea guiada con ultrasonido, en la que puede haber ciertas complicaciones como formación de fístula arteriovenosa, muerte, hemorragia, hidronefrosis, infarto y trombosis, pero su frecuencia varía de 1 a 18% (Troia et al, 2017).…”

Neoplasias del sistema urinario en perros y gatos

“…Além dos neoplasmas renais citados em felinos, a literatura recente inclui um caso de cistoadenoma renal, um com carcinoma de células de transição formando um cisto perirenal, e dois com policitemia induzida por adenocarcinoma renal (Little, 2016). Troia et al (2017) relataram um novo caso de policitemia associada ao adenocarcinoma renal em gato.…”