Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus)

Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

“…Similar results were observed in mice [151] and in crucian carp [152]. Furthermore, the study of Li and colleagues [152] corroborates these results. After an i.p.…”

“…MC-RR exposed fish showed more severe alterations than those exposed to MC-LR, probably due to the greater hydrophilicity of MC-RR [111]. Similar results were observed in mice [151] and in crucian carp [152]. Furthermore, the study of Li and colleagues [152] corroborates these results.…”

Hepatic positive and negative antioxidant responses in zebrafish after intraperitoneal administration of toxic microcystin-LR

“…A potentially hazardous consequence of cyanobacterial blooms is the production of cyanotoxins, such as microcystins (MCs). It is well known that MCs are harmful or toxic to both aquatic animals and mammals including humans (Malbrouck and Kestemont, 2006;Li et al, 2005Li et al, , 2013. So far, there have been identified around 90 molecular variants of MCs (Pearson et al, 2010) and microcystin-LR (MC-LR) is the most common and toxic variant .…”

“…Although MCs have been demonstrated to cause damages to fish intestine, kidney, gills, heart and brain Li et al, 2012;Chen et al, 2012;Trinchet et al, 2011;Li et al, 2013), the liver is the most affected organ in fish, with symptoms of hepatocytes dissociation, degeneration and necrosis (Malbrouck et al, 2003;Li et al, 2007;Li and Xie, 2009). A classic toxic mechanism of MCs is their inhibition of protein phosphatase 1 and 2A, leading to increased protein phosphorylation, which is directly related to their cytotoxicity and tumor promoting activity (Honkanen et al, 1990;MacKintosh et al, 1990).…”

Uptake and Growth Effects of Cyanotoxins on Aquatic Plants Ludwigia Adscendens and Amaranthus Hybridus in Raw Surface Waters

“…The growth in human population and climate change have contributed to an increase in the water temperatures and the load of nutrients reaching many surface waters and thus intensifying the proliferation of the HABs even in temperate climates [4]. The intensity and incidences of CyanoHABs has been on the increase in the last decade, and their ecotoxicological potential has also received growing attention [5], since animal deaths or animal-poisoning episodes attributed to CyanoHABs have been documented in many studies [6], [7].…”