Removal of Urea from Spent Dialysate Using an Enzymatic Method

Bazaev, N. A.; Bizyukov, I. O.; Dorofeeva, Nataliya I; Putrya, B. M.

doi:10.1007/s10527-016-9605-3

Cited by 4 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Urease can hydrolyze urea into NH 3 and H 2 CO 3 (Figure a), and the enzymatic method is considered as an effective way to remove urea . Although the increasing content of ammonia due to hydrolysis of urea may bring the risk of hyperammoniosis, there are many research works focusing on preparing materials for ammonium removal, such as zirconium phosphate, zeolite, and modified zeolite. − Thus, it is believed that ammonium can be removed by many methods. This study serves as a good starting point, and future works will be continued.…”

Section: Resultsmentioning

confidence: 99%

Urease-Immobilized Magnetic Graphene Oxide as a Safe and Effective Urea Removal Recyclable Nanocatalyst for Blood Purification

Zhang

Yan

et al. 2020

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Chronic kidney disease has attracted great attention as a public health disease and is mainly caused by the retention of uremic toxins in the body. Urea is a kind of representative toxin with high solubility and cannot be removed easily; in fact, no suitable absorbers have been found to remove urea by physical adsorption. Herein, we prepare urease-immobilized magnetic graphene oxide as a recyclable nanocatalyst for effective urea removal in blood purification, which shows great removal ability toward urea (2194 ± 110 mg/g). The clearance ratio is over 80% even for a high concentration urea solution of 80 mg/mL, and it is 77% for collected dialysate from a clinic. The nanocatalyst exhibits good reusability and storage stability. Furthermore, a series of blood-related tests indicate that the prepared nanocatalyst has good blood compatibility. Thus, the urease-immobilized recyclable nanocatalyst has great potential for effective and safe urea removal in blood purification.

show abstract