Chronic kidney disease has attracted great attention as a public health disease and is mainly caused by the retention of uremic toxins in the body. Urea is a kind of representative toxin with high solubility and cannot be removed easily; in fact, no suitable absorbers have been found to remove urea by physical adsorption. Herein, we prepare urease-immobilized magnetic graphene oxide as a recyclable nanocatalyst for effective urea removal in blood purification, which shows great removal ability toward urea (2194 ± 110 mg/g). The clearance ratio is over 80% even for a high concentration urea solution of 80 mg/mL, and it is 77% for collected dialysate from a clinic. The nanocatalyst exhibits good reusability and storage stability. Furthermore, a series of blood-related tests indicate that the prepared nanocatalyst has good blood compatibility. Thus, the urease-immobilized recyclable nanocatalyst has great potential for effective and safe urea removal in blood purification.
Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone‐based shell beads are fabricated by phase inversion method, amides and heparin‐like polymer are introduced to functionalize the core‐shell beads. The beads are successfully prepared with obvious core‐shell structure, adequate thermostability and porous shell. Clotting times and protein adsorption are investigated to inspect the hemocompatibility property of the beads. The adsorption of bilirubin is systematically investigated by evaluating the effects of contacting time, initial concentration and temperature on the adsorption, which exhibits improved bilirubin adsorption amount for the beads with amides contained cores or/and shells. It is worth believing that the amides and heparin‐like polymer co‐functionalized core‐shell beads may be utilized in the field of hemoperfusion for bilirubin adsorption.
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