“Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury”

Martinez, Agustina Heredia; Diez, Guillermo Rosa; Ferraris, Verónica; Coccia, Paula; Ferraris, Jorge R.; Checa, Antonio; Wheelock, Craig E.; Lundberg, Jon O.; Weitzberg, Eddie; Carlström, Mattias; Krmar, Rafael T.

doi:10.1016/j.niox.2020.02.004

Cited by 7 publications

(2 citation statements)

References 39 publications

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“…Moreover, a positive association between renal nitrate clearance and kidney function has been observed in patients with CKD 102 . Studies in adult and paediatric patients with kidney failure have shown that peritoneal dialysis and haemodialysis sessions are associated with disturbed NO homeostasis, measured as a reduction in the circulating levels of nitrate, nitrite and cGMP (a marker of NO signalling) 194 – 197 . Clinical studies are needed to investigate the therapeutic value of restoring NO homeostasis, using nitrate and/or nitrite supplementation, in these vulnerable high-risk patients.…”

Section: Approaches To Restoring No Bioactivitymentioning

confidence: 99%

Nitric oxide signalling in kidney regulation and cardiometabolic health

2021

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The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is increasing worldwide. This triad of disorders is associated with considerable morbidity and mortality as well as a substantial economic burden. Further understanding of the underlying pathophysiological mechanisms is important to develop novel preventive or therapeutic approaches. Among the proposed mechanisms, compromised nitric oxide (NO) bioactivity associated with oxidative stress is considered to be important. NO is a short-lived diatomic signalling molecule that exerts numerous effects on the kidneys, heart and vasculature as well as on peripheral metabolically active organs. The enzymatic l -arginine-dependent NO synthase (NOS) pathway is classically viewed as the main source of endogenous NO formation. However, the function of the NOS system is often compromised in various pathologies including kidney, cardiovascular and metabolic diseases. An alternative pathway, the nitrate–nitrite–NO pathway, enables endogenous or dietary-derived inorganic nitrate and nitrite to be recycled via serial reduction to form bioactive nitrogen species, including NO, independent of the NOS system. Signalling via these nitrogen species is linked with cGMP-dependent and independent mechanisms. Novel approaches to restoring NO homeostasis during NOS deficiency and oxidative stress have potential therapeutic applications in kidney, cardiovascular and metabolic disorders.

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Section: Approaches To Restoring No Bioactivitymentioning

confidence: 99%

Nitric oxide signalling in kidney regulation and cardiometabolic health

2021

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“…Carlström et al 13 reported that plasma nitrate and nitrite removal by peritoneal dialysis might predispose infants with low blood pressure to cerebral ischemia. Furthermore, Heredia Martinez et al 14 reported that in patients with end-stage renal disease, HD sessions significantly reduced the markers of NO metabolism and signaling. Moreover, HD significantly reduced circulating levels of nitrate and cyclic guanosine monophosphate (cGMP: molecular weight: 345), indicating that this medical procedure may impair NOS and potentially NO signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Renal replacement therapy removes a large number of nitric oxide donors responsible for the nitrate–nitrite–nitric oxide pathway

2023

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Backgrounds: Nitric oxide has a broad-spectrum antibacterial property promising as a new therapeutic agent for severe acute respiratory syndrome coronavirus-2 because nitric oxide donor (such as S-nitroso-N-acetylpenicillamine) reduces the replication of coronavirus-2. Patients with coronavirus disease 2019 undergoing dialysis generally have a higher mortality rate than the general population. Although the higher mortality rate in these patients may be related to their advanced age, it has been suggested that plasma nitrite and nitrate levels (products of nitric oxide metabolism) are significantly decreased after hemodialysis which may compromise the nitrate–nitrite–nitric oxide pathway and impair nitric oxide homeostasis. It results in increased cardiovascular mortality in patients undergoing dialysis. However, the profile of nitric oxide–producing substances is poorly understood during renal replacement therapy. Methods: We simulated continuous hemodialysis and hemodiafiltration to measure the amount of nitric oxide (nitric oxide-producing substance) clearance in vitro. Results: The results demonstrated increased nitric oxide clearance and higher clearance than creatinine (molecular weight: 113) and vitamin B12 (molecular weight: 1355) using highly efficient renal replacement therapy modes. Conclusion: The high nitric oxide clearance may have partly contributed to the high cardiovascular and coronavirus-2 mortality risk in patients on dialysis.

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