Abstract:Backgrounds: Nitric oxide has a broad-spectrum antibacterial property promising as a new therapeutic agent for severe acute respiratory syndrome coronavirus-2 because nitric oxide donor (such as S-nitroso-N-acetylpenicillamine) reduces the replication of coronavirus-2. Patients with coronavirus disease 2019 undergoing dialysis generally have a higher mortality rate than the general population. Although the higher mortality rate in these patients may be related to their advanced age, it has been suggested that … Show more
“… Nitrite salts , such as sodium nitrite, can be converted to NO in various biological environments. Under acidic conditions or in the presence of certain enzymes, nitrite can generate NO, contributing to the physiological effects of nitrite in vasodilation and cytoprotection Metal-based NO donors : Metal complexes, such as metal-nitrosyl complexes, can act as NO donors.…”
Section: Combination Of No Donors With Nanomaterials:
Challenges and ...mentioning
The free radical nitric oxide (NO) is a signaling molecule that controls several important physiological and pathophysiological processes in mammals and in plants. In humans, the biological impacts of NO include, but are not limited to, key roles in cardiovascular, neurological, immunological, respiratory, and reproductive systems. In plants, NO modulates plant growth and development with important roles in plant defense against biotic and abiotic stress conditions. However, the administration of exogenous NO donors still faces limitations, mainly due to their instability and lack of bioavailability in the biological system. Recently, the combination of nanomaterials with NO donors has been extensively explored as a promising strategy to tailor the spatiotemporal release of therapeutic amounts of NO. Nanoscience offers smart approaches to deliver NO on demand for a particular application. Although this strategy has shown promising results, the combination of NO donors with nanomaterials is still limited to scientific studies and is less explored in agricultural applications compared with biomedical research. The current review summarizes the impact of NO and NO donors in biomedical research and agricultural applications and emphasizes the recent progress in the combination of nanotechnology and NO donors. The advantages, challenges, and drawbacks of this strategy are discussed in light of inspiring research on this exciting topic, aiming to translate these innovations into clinical/practical settings.
“… Nitrite salts , such as sodium nitrite, can be converted to NO in various biological environments. Under acidic conditions or in the presence of certain enzymes, nitrite can generate NO, contributing to the physiological effects of nitrite in vasodilation and cytoprotection Metal-based NO donors : Metal complexes, such as metal-nitrosyl complexes, can act as NO donors.…”
Section: Combination Of No Donors With Nanomaterials:
Challenges and ...mentioning
The free radical nitric oxide (NO) is a signaling molecule that controls several important physiological and pathophysiological processes in mammals and in plants. In humans, the biological impacts of NO include, but are not limited to, key roles in cardiovascular, neurological, immunological, respiratory, and reproductive systems. In plants, NO modulates plant growth and development with important roles in plant defense against biotic and abiotic stress conditions. However, the administration of exogenous NO donors still faces limitations, mainly due to their instability and lack of bioavailability in the biological system. Recently, the combination of nanomaterials with NO donors has been extensively explored as a promising strategy to tailor the spatiotemporal release of therapeutic amounts of NO. Nanoscience offers smart approaches to deliver NO on demand for a particular application. Although this strategy has shown promising results, the combination of NO donors with nanomaterials is still limited to scientific studies and is less explored in agricultural applications compared with biomedical research. The current review summarizes the impact of NO and NO donors in biomedical research and agricultural applications and emphasizes the recent progress in the combination of nanotechnology and NO donors. The advantages, challenges, and drawbacks of this strategy are discussed in light of inspiring research on this exciting topic, aiming to translate these innovations into clinical/practical settings.
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