Removal of intracanal smear by doxycycline in vitro

Barkhordar, Rahmat A.; Watanabe, Larry G.; Marshall, Grayson W.; Hussain, Mansoor

doi:10.1016/s1079-2104(97)90042-1

Cited by 45 publications

(38 citation statements)

References 34 publications

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“…[15] Barkhordar et al concluded that 100 mg/ml solution of doxycycline, because of its acidic capacity is effective to remove smear layer from root surface. [16] It has been reported that doxycycline's’ molecules can react with dentin calcium molecules[17] and this reaction can act as a barrier to dentin, which preclude the penetration of monomer molecules into dentinal tubules and ultimately reduce the bond strength of adhesives to dentin.…”

Section: Discussionmentioning

confidence: 99%

Effect of MTAD on the shear bond strength of self-etch adhesives to dentin

Mortazavi¹,

Khademi²,

Khosravi³

et al. 2012

Dent Res J

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Background:As the use of different irrigants to eliminate residual debris and smear layer in the field of endodontic is unavoidable, by considering the effect of irrigants on the bond strength of resin composite restorations, this study was designed to evaluate the effect of a mixture of a tetracycline isomer, an acid, and a detergent (MTAD) on the shear bond strength of two self-etch adhesives, Clearfil SE Bond and Adper Prompt L- Pop to dentin.Materials and Methods:The crowns of 80 extracted premolars were transversally sectioned to expose dentin. Flat dentin surfaces were wet abraded with 320-grit abrasive paper and randomly assigned to eight groups according to two self-etch adhesive and four dentin surface treatments: direct application over smear layer (no treatment), etching with 35% phosphoric acid for 15s, 1 min 5.25% NaOCl/1 min MTAD and 20min 1.3% NaOCl/5min MTAD. Shear bond strength was tested 24 h after storage in distilled water at 37°C in incubator. Data were analyzed using one-way ANOVA followed by duncan post-hoc (α=0.05).Results:Phosphoric acid etching prior to SE Bond application significantly decreased the shear bond strength to dentin (P<0.05). Application of MTAD clinical protocol (20min 1.3% NaOCl/5min MTAD) did not significantly decrease the shear bond strength of self-etch adhesives to dentin (P=0.745)Conclusions:Based on the results of present investigation, it seems that the use of clinical protocol of 1.3% NaOCl as a root canal irrigant and a 5-min application of MTAD as a final rinse to remove the smear layer has no adverse effect on the shear bond strength of self-etch adhesives to dentin.

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Section: Discussionmentioning

confidence: 99%

Effect of MTAD on the shear bond strength of self-etch adhesives to dentin

Mortazavi¹,

Khademi²,

Khosravi³

et al. 2012

Dent Res J

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“…2003b). This property may be advantageous because, in the absence of bacterial cell lysis, antigenic by‐products such as endotoxin are not released (Barkhordar et al. 1997).…”

Section: Tetracyclinesmentioning

confidence: 99%

“…2002). Inflammatory diseases such as periodontitis include an excess of tissue collagenases, which may be blocked by tetracyclines, thus leading to enhanced formation of collagen and bone (Barkhordar et al. 1997).…”

Section: Tetracyclinesmentioning

confidence: 99%

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On the local applications of antibiotics and antibiotic‐based agents in endodontics and dental traumatology

2009

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Antibiotics are a valuable adjunctive to the armamentarium available to health professionals for the management of bacterial infections. During endodontic treatment and when managing trauma to the teeth, antibiotics may be applied systemically (orally and/or parenterally) or locally (i.e. intra-dentally via irrigants and medicaments). Due to the potential risk of adverse effects following systemic application, and the ineffectiveness of systemic antibiotics in necrotic pulpless teeth and the periradicular tissues, the local application of antibiotics may be a more effective mode for delivery in endodontics. The aim of this article was to review the history, rationale and applications of antibiotic-containing irrigants and medicaments in endodontics and dental traumatology. The search was performed from 1981 to 2008 and was limited to English-language papers. The keywords searched on Medline were 'Antibiotics AND endodontics', 'Antibiotics AND root canal irrigation', 'Antibiotics AND intra-canal medicament', 'Antibiotics AND Dental trauma' and 'Antibiotics AND root resorption'. The reference section of each article was manually searched to find other suitable sources of information. It seems that local routes of antibiotic administration are a more effective mode than systemic applications. Various antibiotics have been tested in numerous studies and each has some advantages. Tetracyclines are a group of bacteriostatic antibiotics with antibacterial substantivity for up to 12 weeks. They are typically used in conjunction with corticosteroids and these combinations have anti-inflammatory, anti-bacterial and anti-resorptive properties, all of which help to reduce the periapical inflammatory reaction including clastic-cell mediated resorption. Tetracyclines have also been used as part of irrigating solutions but the substantivity is only for 4 weeks. Clindamycin and a combination of three antibiotics (metronidazole, ciprofloxacin and minocycline) have also been reported to be effective at reducing bacterial numbers in the root canal systems of infected teeth.

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“…This may also be attributed to the synergistic action of citric acid, doxycycline, and detergent present in MTAD. [7,12,15,18] On evaluation of the degree of erosion it was noted that in the MTAD group, normal tubules with no erosion were seen in all the specimens in coronal and middle areas. In apical areas, tubules with erosion were seen in one specimen, whereas the remaining specimens showed no erosion of tubules.…”

Section: Discussionmentioning

confidence: 93%