Removal of indoxyl sulfate by water-soluble poly-cyclodextrins in dialysis

Li, Jingyu; Han, Lulu; Liu, Shuxin; He, Songbing; Cao, Yaming; Xie, Ju; Jia, Lingyun

doi:10.1016/j.colsurfb.2018.01.056

Cited by 17 publications

(16 citation statements)

References 31 publications

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“…The observation that a polar moiety embedded in a hydrophobic pocket stabilizes the primary IS binding mode may serve as a preliminary mechanistic explanation for the recent finding that cyclodextrin can bind IS from solution. 33 Future work should target a direct connection between molecular modeling and the macroscopic observables that impact CKD patient health. Advanced simulation techniques for quantifying ligand binding affinity and unbinding kinetics represent promising avenues to make this connection.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the Molecular Interactions between Uremic Toxins and the Sudlow II Binding Site of Human Serum Albumin

Smith

Pfaendtner

2020

J. Phys. Chem. B

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FIGURESFigure S1. Binding poses used to initialize (top left) indoxyl sulfate-HSA, (top right) p-cresyl sulfate-HSA, (bottom left) indole-3-acetic acid-HSA, and (bottom right) hippurate-HSA simulations.The initial protein structure (transparent gray) is taken in all 4 cases from the experimental x-ray structure for IS bound to Sudlow's Site II (PDB ID: 2BXH), and each toxin molecule (opaque ball and stick) was superimposed in place of the experimentally resolved IS molecule (transparent, colored by atom).

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Section: Discussionmentioning

confidence: 99%

Elucidating the Molecular Interactions between Uremic Toxins and the Sudlow II Binding Site of Human Serum Albumin

Smith

Pfaendtner

2020

J. Phys. Chem. B

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“…Cyclodextrins (CDs) are toroidal-shaped cyclic oligosaccharides composed of 6-8 D-glucose units (α, β, γ), with a hydrophilic exterior and a relatively hydrophobic inner cavity, which can encapsulate different low molecular weight lipophilic guests or macromolecules [ 55 , 56 ]. The cup-shaped β-CD is composed of 7 glucose units, and is most commonly applied due to its sensitive recognition of diverse hydrophobic molecules by forming CD-guest complex.…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

“…Li et al proposed for the first time that adding crosslinked poly-β-cyclodextrins (PCD) into the dialysate of exterior dialyzer for improving mass-transfer efficiency of indoxyl sulfate (IS) (Fig. 8 a) [ 56 ]. PCD was synthesized by a cross-link between β-CD and epichlorohydrin (ECH).…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

“…β-CD firstly dissolved in NaOH solution, then ECH was added into the mixture, which was subsequently stirred at 30 °C for 2 h. According to the original study, the maximum binding capacity of PCD for IS about 45 mg g -1 and a 21% increase in removal rate has been achieved in the simulated dialysis experiment with introduction of PCD. The mechanism of IS binding to PCD may be that the indole ring of IS is accommodated in the cavity of β-CD through hydrophobic interaction and hydrogen bonding [ 56 ]. This new strategy exerts no negative impact on dialysis membrane, and is safe for clinical application since PCD has been proved with a low hemolysis rate and could not traverse the membrane to contact with the blood (hydrodynamic diameter of polymer is 9nm).…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

“…8 a Schematic representation of the two-compartment recirculation dialysis system with PCD as the adsorbent (a dialysate-recycled mode). Reproduced with permission [ 56 ]. Copyright 2018, Elsevier.…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

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Recent trends in therapeutic application of engineered blood purification materials for kidney disease

et al. 2022

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Blood purification is a commonly used method to remove excess metabolic waste in the blood in renal replacement therapy. The sufficient removal of these toxins from blood can reduce complications and improve survival lifetime in dialysis patients. However, the current biological blood purification materials in clinical practice are not ideal, where there is an unmet need for producing novel materials that have better biocompatibility, reduced toxicity, and, in particular, more efficient toxin clearance rates and a lower cost of production. Given this, this review has carefully summarized newly developed engineered different structural biomedical materials for blood purification in terms of types and structure characteristics of blood purification materials, the production process, as well as interfacial chemical adsorption properties or mechanisms. This study may provide a valuable reference for fabricating a user-friendly purification device that is more suitable for clinical blood purification applications in dialysis patients. Graphical Abstract

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Hierarchically structural polyacrylonitrile/MIL‐101(Cr) nanofibrous membranes with super adsorption performance for indoxyl sulfate

Ding

Meng

et al. 2022

J of Applied Polymer Sci

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Excess protein-bound uremic toxins (such as indoxyl sulfate [IS]) in the blood could aggravate chronic kidney disease and also predispose to serious cardiovascular disease. In this study, we constructed a novel IS adsorbent polyacrylonitrile/MIL-101(Cr) (PAN-M) nanofibrous membrane with high adsorption capacity and ultra-fast sorption rate for IS. The porous metal-organic framework MIL-101(Cr) were embedded in PAN nanofibers by electrospinning as an adsorbent for easy recovery. It was found that MIL-101(Cr) had a strong electrostatic effect on the SO 3 À of IS and could reach the adsorption equilibrium within 5 min. Notably, MIL-101(Cr) showed an extremely high adsorption capacity ($170 mg/g) for IS. The MIL-101(Cr) loading of prepared PAN-M nanofibrous membrane was optimized at 60 wt% and the optimal PAN-M60 exhibited an appreciable IS adsorption capacity (103 mg/g). The removal of IS was enhanced from 35.4% to 62.5% during hemodialysis by using PAN-M60 as adsorbent immersed in dialysate. This efficient adsorption performance can greatly reduce the consumption of dialysate and may shorten the hemodialysis time. This work would provide a fresh perspective on the development of MOF-based adsorbents to improve hemodialysis therapies.

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Removal of indoxyl sulfate by water-soluble poly-cyclodextrins in dialysis

Cited by 17 publications

References 31 publications

Elucidating the Molecular Interactions between Uremic Toxins and the Sudlow II Binding Site of Human Serum Albumin

Elucidating the Molecular Interactions between Uremic Toxins and the Sudlow II Binding Site of Human Serum Albumin

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

Hierarchically structural polyacrylonitrile/MIL‐101(Cr) nanofibrous membranes with super adsorption performance for indoxyl sulfate

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