Removal of all radioactive sentinel nodes in breast cancer improves the detection of positive sentinel nodes

Rubio, Isabel T.; Pedreira, Felisardo; Roca, Isabel; Cabaleiro, Antón; Mendoza, C.; Córdoba, Octavi; Cortadellas, T.; Sabadell, Dolors; Xercavins, Jordi

doi:10.1007/s12094-008-0210-0

Cited by 3 publications

(3 citation statements)

References 25 publications

(25 reference statements)

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“…In those patients who had an SLN, the isotope (Tc99 sulfur colloid) was injected subareolar in the breast the day before the surgery as previously reported 16.…”

Section: Methodsmentioning

confidence: 99%

Extensive nodal involvement increases the positivity of blue nodes in the axillary reverse mapping procedure in patients with breast cancer

Rubio

Cebrecos

Peg

et al. 2012

Journal of Surgical Oncology

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“…In those patients who had an SLN, the isotope (Tc99 sulfur colloid) was injected subareolar in the breast the day before the surgery as previously reported 16.…”

Section: Methodsmentioning

confidence: 99%

Extensive nodal involvement increases the positivity of blue nodes in the axillary reverse mapping procedure in patients with breast cancer

Rubio

Cebrecos

Peg

et al. 2012

Journal of Surgical Oncology

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“…Non-SLN metastases have been reported in four to seven percent of SLN-negative cases [6]. It is crucial to consider the number of nodes that should be excised for diagnosis and staging and from the perspective of the therapeutic benefit of local control [7][8][9][10][11]. We agreed that the examination of four SLN-containing nodes was sufficient to determine the status of metastases in the axilla.…”

Section: Number Of Nodes Required For Diagnosismentioning

confidence: 94%

Identifying Gaps in the Locoregional Management of Early Breast Cancer: Highlights from the Kyoto Consensus Conference

et al. 2011

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A consensus conference was held to investigate issues related to the local management of early breast cancer. Here, we highlight the major topics discussed at the conference and propose ideas for future studies. Regarding axillary management, we examined three major issues. First, we discussed whether the use of axillary reverse mapping could clarify the lymphatic system of breast and whether the ipsilateral arm might help avoid lymphedema. Second, the use of an indocyanine green fluorescent navigation system was discussed for intraoperative lymphatic mapping. These new issues should be examined further in practice. Finally, some agreement was reached on the importance of "four-node diagnosis" to aid in the diagnostic accuracy of sentinel nodes. Regarding breast treatment, there was general agreement that the clinical value of surgical margins in predicting local failure was dependent on the tumor's intrinsic biology and subtypes. For patients treated with preoperative chemotherapy, less extensive excision may be feasible in those who respond to systemic therapy in an acceptable manner. Most trials of preoperative chemotherapy lack outcome data on local recurrence. Therefore, there is a need for such data for overview analysis. We also agreed that radiation after mastectomy may be beneficial in node-positive cases where more than four nodes are involved. Throughout the discussions for both invasive and noninvasive disease, the investigation of nomograms was justified for major issues in the decision-making process, such as the presence or absence of microinvasion and the involvement of nonsentinel nodes in sentinel node-positive patients.

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“…4,5 Since sentinel lymph node biopsy involves fewer risks and less morbidity, it has gained followers worldwide and is currently the standard treatment for axillary management in breast cancer patients. 6 This method enables axillary involvement to be diagnosed with good sensitivity. Therefore, complete dissection of the axillary lymph nodes became restricted to those cases in which metastases are detected in the sentinel lymph node.…”

Section: Introductionmentioning

confidence: 99%

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

Paulinelli

Freitas‐Junior

Rahal

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction:Methylene blue is more widely available and less expensive than patent blue, with an apparently lower risk of anaphylaxis. Objective: The two dyes were compared regarding detection of the sentinel lymph node (SLN). Method: A prospective, randomized trial involved 142 patients with invasive breast carcinoma. Sixty-nine (49.3%) assigned to patent blue (group A) and 71 (50.70%) to methylene blue (group B). Thirty-five patients (25.0%) were clinical stage III or IV; 55 (38.7%) had axillary lymph nodes affected; and 69 (49.3%) underwent neoadjuvant chemotherapy. Two patients were excluded because the dye type was not recorded. Results: Patients and tumor characteristics were similar in both groups. SLNs were identified in 47 women (68.1%) in group A and 43 (60.6%) in group B (p=0.35). SLNs were affected in 22 cases (51.2%) in group A and 21 (48.8%) in group B (p=0.62). The SLN was the only node affected in 12 cases (54.5%) in group A and six (33.3%) in group B (p=0.18). The time and degree of difficulty involved in identifying the SLN were similar in both groups. There were no complications or allergies. Conclusion: Methylene blue performed as well as patent blue in identifying the SLN in breast cancer patients.

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Removal of all radioactive sentinel nodes in breast cancer improves the detection of positive sentinel nodes

Abstract: Lymphoscintigraphy does not accurately predict the number of SLNs identified intraoperatively, this number being underestimated. Surgeons should remove all radioactive SLNs to improve the detection of positive SLNs.

Cited by 3 publications

References 25 publications

Extensive nodal involvement increases the positivity of blue nodes in the axillary reverse mapping procedure in patients with breast cancer

Extensive nodal involvement increases the positivity of blue nodes in the axillary reverse mapping procedure in patients with breast cancer

Identifying Gaps in the Locoregional Management of Early Breast Cancer: Highlights from the Kyoto Consensus Conference

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

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