Remote control of the recruitment and capture of endogenous stem cells by ultrasound for in situ repair of bone defects

He, Yanni; Li, Fēi; Jiang, Peng; Cai, Feiyan; Qi, Lin; Zhou, Meijun; Li, Hongmei; Yan, Fei

doi:10.1016/j.bioactmat.2022.08.012

Cited by 22 publications

(25 citation statements)

References 70 publications

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“…(c) Schematic design of endogenous bioprinted bone mesenchymal stem cells repairing bone defect by the ultrasound, and the coordinated irradiation of pulsed ultrasound (p‐US) and sinusoidal continuous wave ultrasound (s‐US) drives the release of factors, captures recruited endogenous stem cells and promotes bone regeneration in situ. (d) Representative fluorescence images of rats treated with daily 20‐min p‐US irradiation for different days, and these circles marked with white‐dotted lines denote the initial site of the scaffold [149] . Copyright 2023, Elsevier.…”

Section: Stimulus‐responsive Scaffolds For Bone Regenerationmentioning

confidence: 99%

Advanced strategies of scaffolds design for bone regeneration

Song,

Li,

Fang

et al. 2023

BMEMat

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Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects. In this review article, we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair, especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli. We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment. Finally, we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds, aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.

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Section: Stimulus‐responsive Scaffolds For Bone Regenerationmentioning

confidence: 99%

Advanced strategies of scaffolds design for bone regeneration

Song,

Li,

Fang

et al. 2023

BMEMat

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“…There was no significant difference in the chemotaxis of rPDSCs between SDF-1α-nHA/SF and SDF-1α/CGRP-nHA/SF artificial periosteum. This may be related to the addition of SDF-1α, which has the effect of cell chemotaxis and can regulate the adhesion/chemotaxis of rPDSC by activating/regulating specific integrin molecules …”

Section: Resultsmentioning

confidence: 99%

“…This may be related to the addition of SDF-1α, which has the effect of cell chemotaxis and can regulate the adhesion/ chemotaxis of rPDSC by activating/regulating specific integrin molecules. 54 ALP is a hallmark enzyme for osteogenic differentiation, and its qualitative staining and quantitative assay allowed for the evaluation of the pro-osteogenic differentiation of rPDSCs cultured on various samples. As shown in Figure 3E and F, CGRP-nHA/SF and SDF-1α/CGRP-nHA/SF groups showed significantly better osteogenic differentiation activities compared with the nHA/SF and SDF-1α-nHA/SF groups.…”

Section: Characterization Of Sdf-1α/cgrp-nha/sf Artificial Periosteummentioning

confidence: 99%

Dual Factor-Loaded Artificial Periosteum Accelerates Bone Regeneration

Yao,

Liang,

Zeng

et al. 2024

ACS Biomater. Sci. Eng.

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In the clinic, inactivation of osteosarcoma using microwave ablation would damage the periosteum, resulting in frequent postoperative complications. Therefore, the development of an artificial periosteum is crucial for postoperative healing. In this study, we prepared an artificial periosteum using silk fibroin (SF) loaded with stromal cell-derived factor-1α (SDF-1α) and calcitonin gene-related peptide (CGRP) to accelerate bone remodeling after the microwave ablation of osteosarcoma. The prepared artificial periosteum showed a sustained release of SDF-1α and CGRP after 14 days of immersion. In vitro culture of rat periosteal stem cells (rPDSCs) demonstrated that the artificial periosteum is favorable for cell recruitment, the activity of alkaline phosphatase, and bone-related gene expression. Furthermore, the artificial periosteum improved the tube formation and angiogenesis-related gene expression of human umbilical vein endothelial cells (HUVECs). In an animal study, the periosteum in the femur of a rabbit was inactivated through microwave ablation and then removed. The damaged periosteum was replaced with the as-prepared artificial periosteum and favored bone regeneration. In all, the designed dual-factor-loaded artificial periosteum is a promising strategy to replace the damaged periosteum in the therapy of osteosarcoma for a better bone-rebuilding process.

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“…(C1) Utilizing ultrasonic stimulation, a system involving bone structure cells (BSCs) and an artificial resonance system (ARS) repairs bone defects, attracting and capturing endogenous BMSCs for in situ bone tissue regeneration. 238 Copyright 2020, Elsevier; (C2) explanation of the antibacterial mechanism induced by acoustic cavitation. 239 Copyright 2020, Elsevier.…”

Section: Surface Micro-nano Structurementioning

confidence: 99%