Remote C−H Activation of Various N‐Heterocycles Using a Single Template

Abstract

A single and simple ortho-sulfonyl benzonitrile template was developed to achieve remote C-H olefination of six different classes of N-heterocycles. We demonstrate that, by varying precatalysts and conditions, the same template can be applied to the remote C-H activation of six structurally distinct heterocyclic scaffolds, and the site-selectivity can be predicted based on distance and geometry. Furthermore, this new development shows that template-directed remote C-H activation is possible through macrocyclopalladation processes with smaller ring sizes.

Accessing Remote meta‐ and para‐C(sp2)−H Bonds with Covalently Attached Directing Groups

“…[29] Thet emplate reported by the same group for tetrahydroquinoline (Scheme 5) [15] was found to be ineffective for tetrahydroisoquinoline,p resumably because of the nitrogen atom being conformationally less rigid. [29] Thet emplate reported by the same group for tetrahydroquinoline (Scheme 5) [15] was found to be ineffective for tetrahydroisoquinoline,p resumably because of the nitrogen atom being conformationally less rigid.…”

Zugang zu meta‐ und para‐C(sp2)‐H‐Bindungen mithilfe kovalent gebundener dirigierender Gruppen

“…Kürzlich wurde ein Sulfonyl‐Linker zur Funktionalisierung der C8‐Position des Tetrahydroisochinolins entwickelt (Schema ) . Das von der gleichen Arbeitsgruppe beschriebene Templat für Tetrahydrochinolin (Schema ) erwies sich als unwirksam beim Tetrahydroisochinolin, vermutlich aufgrund des Stickstoffatoms, das konformativ weniger starr ist.…”

Synthesis of TiO2 on different substrates by chemical vapor deposition for photocatalytic reduction of Cr(VI) in water

“…It is based on electrons and holes generated on the TiO 2 surface when illuminated by light with energy greater than the band gap energy. These electrons and holes recombine or participate in redox reactions to reduce Cr(VI) to the less harmful Cr(III), which can be precipitated in neutral or alkaline solutions as Cr(OH) 3 …”

“…Thus, research on the application of TiO 2 films in the reduction of Cr(VI) is particularly promising. It was reported that the photocatalytic activity of the thin film can be compared with that of the commercial powder TiO 2 . A number of methods have been used to prepare TiO 2 films, including chemical vapor deposition (CVD), chemical spray pyrolysis, electrodeposition, and the sol–gel method .…”