Remote Afterloading for Neutron Brachytherapy Using Californium-252

Abstract

The technologic concept of the present automatic afterloading device for neutron brachytherapy represents a possible option from the range of conceivable design variants, which - while minimizing technologic and economic requirements - provides the operating personnel with optimum protection and work safety, thus extending the applicability of high LET radiation-based treatment methods in clinical practice.

Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays

“…The 5-year overall survival rate of cervical cancer patients who received 252 Cf neutron ray radiotherapy was reported to be 76.8% at stage II and 70.9% at stage III [5]. Another study showed that the 10-year survival rate was better in cervical cancer patients treated with 252 Cf neutron rays than in those treated with gamma radiation (69.1% vs. 50.9%, respectively) [6]. However, despite the improved efficacy of 252 Cf neutron rays in the therapy of cervical cancer, tumors recurrence has been reported.…”

Hypoxic Versus Normoxic External-Beam Irradiation of Cervical Carcinoma Combined with Californium-252 Neutron Brachytherapy

“…The present progress in the technology of production of the miniaturized, highly active source of the 252 Cf nuclide [14,23] as well as the progress in the design concept of the remote afterloading system applied to these sources satisfy the preconditions for introducing neutron brachytherapy in clinical practice [31].…”