Remission Rates in Breast Cancer Treated with Preoperative Chemotherapy and Radiotherapy

Gerlach, B.; Audretsch, Werner; Gogolin, Frank; Königshausen, Theodor; Rohn, Ralf; Schmitt, G; Dimmerling, P.; Gripp, Stephan; Hartmann, Karl

doi:10.1007/s00066-003-1019-y

Cited by 42 publications

(47 citation statements)

References 30 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The need for axillary lymph node dissection is challenged by these facts, since side effects of breast cancer surgery are mainly related to axillary lymph node dissection [1]. Moreover, an increasing number of patients is treated by neoadjuvant chemotherapy [16]. In these patients the role of axillary lymph node dissection for prognosis and locoregional control of the tumor is also uncertain [16].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Axillary Lymph Node Status of Breast Cancer Patients by Tumorbiological Factors of the Primary Tumor

Fehm

Maul

Gebauer³

et al. 2005

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Prediction of Axillary Lymph Node Status of Breast Cancer Patients by Tumorbiological Factors of the Primary Tumor

Fehm

Maul

Gebauer³

et al. 2005

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

“…Significant controversy surrounds targeting of the IMNs with RT [1,2,4,6,8,9,12,13,18,19,24,25,[28][29][30][31][32][33]. Recent analysis of patients treated in the Danish randomized trials who received RT to the chest wall and regional lymphatics including IMNs did not show an adverse effect on cardiovascu- [14].…”

Section: Targeting Internal Mammary Nodes By Radiation Therapymentioning

confidence: 99%

Internal Mammary Nodes in Invasive Breast Carcinoma

Grabenbauer

2004

Strahlenther Onkol

View full text Add to dashboard Cite

show abstract

“…Local hyperthermia was delivered with 43.5-44.5 °C over 60 min immediately before interstitial radiotherapy. Details of treatment have been described previously [1,15,16]. 214 neoadjuvant patients (82/100 patients with cT1-T2 tumors, 84/137 patients with cT3 tumors, and 48/78 patients with cT4 tumors) received only an electron boost after external-beam radiotherapy and no interstitial boost.…”

Section: Interstitial Therapy 101 Patients Received An Interstitial Bmentioning

confidence: 99%

Retrospective Study of Neoadjuvant Versus Adjuvant Radiochemotherapy in Locally Advanced Noninflammatory Breast Cancer

et al. 2010

Self Cite

View full text Add to dashboard Cite

Purpose: This retrospective study compares patients treated between 1991 and 1998 with neoadjuvant radiotherapy ± chemotherapy (RCT) or adjuvant RCT for locally advanced noninflammatory breast cancers (LABC) in terms of pathologic complete response (pCR), 10-year relapse-free (RFS), and overall survival (OS). Patients and Methods: Preoperative RCT in 315 and adjuvant RCT in 329 cases consisted in 50 Gy (5 × 2 Gy/week) to the breast and the supra-/infraclavicular lymph nodes. 101 neoadjuvant patients received -in case of breast conservation -a 10-Gy interstitial boost with 192 Ir afterloading before and 214 neoadjuvant patients a preoperative electron boost after external-beam radiotherapy. In the neoadjuvant RCT group, chemotherapy was applied prior to radiotherapy in 192 patients, and simultaneously in 113; ten had no chemotherapy. In the adjuvant RCT group, chemotherapy was applied to 44 patients before surgery and to 166 after surgery; 119 had no chemotherapy. Results: Breast conservation became possible in 50.8% after neoadjuvant RCT for LABC with a pCR rate at surgery of 29.2%. A complete nodal remission (pN0) after RCT was observed in 56% (89/

show abstract

Remission Rates in Breast Cancer Treated with Preoperative Chemotherapy and Radiotherapy

Abstract: Combination of neoadjuvant chemo-/radiotherapy results in significantly higher rates of complete remission than neoadjuvant chemotherapy alone. The significance for tumor-free and overall survival has to be evaluated.

Cited by 42 publications

References 30 publications

Prediction of Axillary Lymph Node Status of Breast Cancer Patients by Tumorbiological Factors of the Primary Tumor

Prediction of Axillary Lymph Node Status of Breast Cancer Patients by Tumorbiological Factors of the Primary Tumor

Internal Mammary Nodes in Invasive Breast Carcinoma

Retrospective Study of Neoadjuvant Versus Adjuvant Radiochemotherapy in Locally Advanced Noninflammatory Breast Cancer

Contact Info

Product

Resources

About