Remission Rates Following Preoperative Chemotherapy and Radiation Therapy in Patients with Breast Cancer

Aryus, Bärbel; Audretsch, Werner; Gogolin, Frank; Gripp, S.; Königshausen, Theodor; Lammering, Guido; Rohn, Ralf; Hartmann, Karl

doi:10.1007/pl00002349

Cited by 25 publications

(26 citation statements)

References 19 publications

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“…External validity of our study has recently been given indirectly by publication of the results of a non-randomized comparison of neoadjuvant radio-chemotherapy versus neoadjuvant chemotherapy alone [43]. A randomized study has been initiated.…”

Section: Discussionmentioning

confidence: 99%

Long‐term results of neoadjuvant radiation therapy for breast cancer

Calitchi

Kirova

Otmezguine

et al. 2001

Intl Journal of Cancer

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SUMMARY Our aim was to determine the long-term outcome and the possible role of neoadjuvant (preoperative) radiation therapy for breast cancers unsuitable for primary conservative surgery. From 1977 to 1992, 75 unifocal non-inflammatory and non-metastatic T2 and T3 breast cancers were treated in our department. All these patients underwent initial radiotherapy, followed by secondary limited surgery. A population of 74 patients, aged from 32 to 82 years (median 56 years), presenting 49 T2 and 26 T3 tumors, was studied. Seventy-two patients (96%) underwent secondary tumorectomy and three patients (4%) reduction mammaplasty. The secondary tumorectomy was followed by a postoperative boost. There were nine recurrences, treated by mastectomy in eight cases and by tumorectomy in one case. Twenty-five patients showed secondary dissemination. Forty-seven patients are still alive and free of disease. The cosmetic results were considered excellent or satisfactory in 71 cases. Under good conditions, preoperative radiotherapy (as well as preoperative chemotherapy) allows the possibility of conservative surgery for cancers of more than 3 cm. The choice between the two modalities depends on the patient's condition and on a precise analysis of all prognostic factors that would justify the need for systemic treatment.

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Section: Discussionmentioning

confidence: 99%

Long‐term results of neoadjuvant radiation therapy for breast cancer

Calitchi

Kirova

Otmezguine

et al. 2001

Intl Journal of Cancer

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“…Surgery is performed in every patient without distant metastases irrespective of the primary tumor response as assessed by palpation, ultrasound, or nuclear magnetic resonance. In a small series, we have achieved a histopathologically complete response in 24 out of 56 tumors, which was significantly more than after induction chemotherapy alone [2]. We here present the extended singleinstitution experience with 134 patients who underwent preoperative chemo-/radiotherapy and had a final histopathologic assessment of the tumor response.…”

Section: Introductionmentioning

confidence: 94%

“…In this overview, all types of surgery were included. Based on several randomized clinical trials with follow-up times > 10 years, breast-preserving surgery and subsequent radiotheraphy are regarded as a safe treatment option for stage I and II tumors with respect to local recurrence-free survival and overall survival [2,4,13,19,26,27,34,35]. Postmastectomy radiotherapy has regained interest, and large randomized trials have demonstrated an overall survival benefit [11].…”

Section: Introductionmentioning

confidence: 99%

Remission Rates in Breast Cancer Treated with Preoperative Chemotherapy and Radiotherapy

et al. 2003

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“…Local hyperthermia was delivered with 43.5-44.5 °C over 60 min immediately before interstitial radiotherapy. Details of treatment have been described previously [1,15,16]. 214 neoadjuvant patients (82/100 patients with cT1-T2 tumors, 84/137 patients with cT3 tumors, and 48/78 patients with cT4 tumors) received only an electron boost after external-beam radiotherapy and no interstitial boost.…”

Section: Interstitial Therapy 101 Patients Received An Interstitial Bmentioning

confidence: 99%

Retrospective Study of Neoadjuvant Versus Adjuvant Radiochemotherapy in Locally Advanced Noninflammatory Breast Cancer

et al. 2010

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Purpose: This retrospective study compares patients treated between 1991 and 1998 with neoadjuvant radiotherapy ± chemotherapy (RCT) or adjuvant RCT for locally advanced noninflammatory breast cancers (LABC) in terms of pathologic complete response (pCR), 10-year relapse-free (RFS), and overall survival (OS). Patients and Methods: Preoperative RCT in 315 and adjuvant RCT in 329 cases consisted in 50 Gy (5 × 2 Gy/week) to the breast and the supra-/infraclavicular lymph nodes. 101 neoadjuvant patients received -in case of breast conservation -a 10-Gy interstitial boost with 192 Ir afterloading before and 214 neoadjuvant patients a preoperative electron boost after external-beam radiotherapy. In the neoadjuvant RCT group, chemotherapy was applied prior to radiotherapy in 192 patients, and simultaneously in 113; ten had no chemotherapy. In the adjuvant RCT group, chemotherapy was applied to 44 patients before surgery and to 166 after surgery; 119 had no chemotherapy. Results: Breast conservation became possible in 50.8% after neoadjuvant RCT for LABC with a pCR rate at surgery of 29.2%. A complete nodal remission (pN0) after RCT was observed in 56% (89/

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Remission Rates Following Preoperative Chemotherapy and Radiation Therapy in Patients with Breast Cancer

Cited by 25 publications

References 19 publications

Long‐term results of neoadjuvant radiation therapy for breast cancer

Long‐term results of neoadjuvant radiation therapy for breast cancer

Remission Rates in Breast Cancer Treated with Preoperative Chemotherapy and Radiotherapy

Retrospective Study of Neoadjuvant Versus Adjuvant Radiochemotherapy in Locally Advanced Noninflammatory Breast Cancer

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