Remission of the Renal Involvement in a Patient with Primary Sjo¨gren’s Syndrome (SS) after Pulse High-Dose Corticosteroid Infusion Therapy

Saeki, Yukihiko; Ohshima, Satoshi; Ishida, Tatsuhiro; Shima, Yoshihito; Umeshita-Sasai, Mitsuko; Nishioka, Kiyoshi; Yamaguchi, Norihiko; Suemura, Masaki

doi:10.1007/pl00011200

Cited by 22 publications

(7 citation statements)

References 7 publications

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“…Eighteen studies reported the management of 32 patients with pSS and biopsyproven renal disease: 14 with IN, 16 GN, and two IN+GN (9,16,18,19,21,24,26,35,36,40,47,48,50,52,(54)(55)(56)(57). Seventeen patients were treated with a combination of corticosteroids and cyclophosphamide, and 15 patients received only steroids with improvement in the majority of cases (Table 1).…”

Section: Literature Reviewmentioning

confidence: 99%

Sjögren's syndrome – not just Sicca: renal involvement in Sjögren's syndrome

Kaufman¹,

Schwartz

Caspi³

et al. 2008

Scandinavian Journal of Rheumatology

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Section: Literature Reviewmentioning

confidence: 99%

Sjögren's syndrome – not just Sicca: renal involvement in Sjögren's syndrome

Kaufman¹,

Schwartz

Caspi³

et al. 2008

Scandinavian Journal of Rheumatology

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“…They concluded that TIN associated with SS has proved to be a rather benign condition, as none of the patients presented with end-stage renal failure. On the other hand, cases of TIN with renal failure have been reported; [8][9][10][11] and although there have been no controlled studies on renal failure, corticosteroids and cytotoxic drugs are empirically used with frequently favorable outcomes. Moreover, no patients with TIN who presented with renal failure requiring continuous hemodialysis have been reported.…”

Section: Discussionmentioning

confidence: 99%

Marked hypocomplementemia and tubulointerstitial nephritis in a male patient with Sj�gren?s syndrome

et al. 2004

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We report a case of marked hypocomplementemia and tubulointerstitial nephritis associated with Sjögren's syndrome (SS) in a male patient. Renal biopsy revealed tubulointerstitial nephritis but did not identify specific immune deposits of the tubulo-interstitium. After steroid therapy, the renal failure and hypocomplementemia diminished. Hypocomplementemia without cryoglobulinemia is not commonly observed in SS patients, and hypocomplementemic tubulointerstitial nephritis was strongly suspected. Hypocomplementemic tubulointerstitial nephritis is rare; only one case has been described in the literature. In our case and the previous case, the patients were elderly men, and they had some similar clinical characteristics. Idiopathic hypocomplementemic tubulointerstitial nephritis resembling our case has been reported. These facts suggest that hypocomplementemic tubulointerstitial nephritis may occur in patients with SS, and such cases may not be as rare as once thought because it might be appropriate to include them in the category of idiopathic cases. Such a syndrome should be included in the differential diagnosis of hypocomplementemia.

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“…Combination of corticosteroids and other immunosuppressants have been reported to slow progression of renal damage in Sjogren's syndrome2 8 but the efficacy of the treatment has been largely demonstrated only in patients with rapidly progressing renal damage or insufficiency 2 8 9. In fact, in a case reported by Reddy et al 10, hypokalaemia and acidosis recurred after tapering the dose of prednisolone, having given it for 6 months.…”

Section: Discussionmentioning

confidence: 99%

Sjogren's syndrome with distal renal tubular acidosis presenting as hypokalaemic paralysis

Vaidya¹,

Ganeshpure

2012

BMJ Case Reports

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SummaryA young lady with a history of repeated episodes of generalised weakness and fatigue presented to our hospital with similar symptoms and was found to have severe hypokalaemia. She had been previously diagnosed as hypokalaemic periodic paralysis but during this presentation she had also started complaining of the classic sicca-complex of Sjogren's syndrome, which was not present previously. On subsequent investigations she was found to have normal anion-gap metabolic acidosis with positive urine anion gap consistent with the diagnosis of distal renal tubular acidosis (RTA). It was thus concluded that the distal RTA secondary to Sjogren's syndrome was the cause of severe hypokalaemia in our patient. By presenting this case we aim to not only highlight one of the rare presentations of Sjogren's syndrome but also the favourable response of our patient to potassium replacement alone. BACKGROUND

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Remission of the Renal Involvement in a Patient with Primary Sjo¨gren’s Syndrome (SS) after Pulse High-Dose Corticosteroid Infusion Therapy

Cited by 22 publications

References 7 publications

Sjögren's syndrome – not just Sicca: renal involvement in Sjögren's syndrome

Sjögren's syndrome – not just Sicca: renal involvement in Sjögren's syndrome

Marked hypocomplementemia and tubulointerstitial nephritis in a male patient with Sj�gren?s syndrome

Sjogren's syndrome with distal renal tubular acidosis presenting as hypokalaemic paralysis

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