Remission of Acanthosis Nigricans, Hypertrichosis, and Hashimoto's Thyroiditis with Thyroxine Replacement

Jh, Dix; Wj, Levy; Fuenning, Charles

doi:10.1111/j.1525-1470.1986.tb00533.x

Cited by 14 publications

(3 citation statements)

References 30 publications

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“…The association of AN with rare syndromes has been described: Barter syndrome, 24 Benign encephalopathy, 25 Bloom syndrome, 26 Chondrodystrophy with dwarfism, 27 Costello syndrome, 28 Dermatomyositis, 29 Familial pineal body hypertrophy, 30 Gigantism, 7 Hashimoto thyroiditis, 31 Hirschowitz syndrome, 32 Lipoatrophic diabetes mellitus, 33 Lupoid hepatitis, 34 Lupus erythematosus, 35 Phenylketonuria, 36 Pituitary hypogonadism, 37 Pseudoacromegaly, 38 Prader‐Willi syndrome, 39 Rud syndrome, 40 Scleroderma, 41 Type A syndrome (HAIR‐AN syndrome), 42 Werner syndrome, 43 Wilson syndrome 44 …”

Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans: A review

Das

Datta²,

Kassir

et al. 2020

J of Cosmetic Dermatology

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Background Acanthosis nigricans (AN) is a cutaneous disorder characterized by symmetric velvety hyperpigmented plaques on intertriginous areas like axilla, neck, inframammary, and groin. Aims To summarize the pathophysiology and classification of AN, provide an update of diagnostic testing strategies, and describe the current therapeutic options described so far in the literature for this disease. Methods A comprehensive english language literature search across multiple databases (PubMed, EMBASE, MEDLINE, and Cochrane) for keywords (alone and in combination) was performed. MeSH as well as non‐MeSH terms such as “acanthosis nigricans,” “classification,” “pathophysiology,” “diagnosis,” “treatment,” “topical drugs,” “systemic drugs,” “chemical peeling,” and “lasers” were taken into consideration. Results The pathophysiology of AN revolves around a multifactorial stimulation of proliferation of epidermal keratinocytes and dermal fibroblasts. Various types of AN include benign, obesity‐associated, syndromic, malignant, acral, unilateral, medication‐induced, and mixed‐type. Homeostasis model assessment‐insulin resistance (HOMA‐IR) is a good tool for assessment of insulin resistance. Management involves general measures (weight reduction and addressing the underlying cause, if any), topical drugs (retinoids, vitamin D analogs, and keratolytics), oral drugs (retinoids and insulin sensitizers), chemical peels (trichloroacetic acid), and lasers (Long pulsed alexandrite, fractional 1550‐nm erbium fiber, and CO2). Conclusion Acanthosis nigricans is a treatable condition; however, complete cure and disappearance of lesions are difficult to achieve. Weight reduction is the most scientific and practical management strategy. Long‐term studies and further research is warranted in the pathophysiology and treatment of this common condition.

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Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans: A review

Das

Datta²,

Kassir

et al. 2020

J of Cosmetic Dermatology

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“…These cutaneous changes seem not to be correlated with thyroid metabolism, and their role in the pathogenesis of these associations is often unknown. However, they improve after hormone replacement (3).…”

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confidence: 99%

Acquired Ichthyosis and Hypertrichosis due to Autoimmune Thyroiditis: Therapeutic Response to Thyroxine Replacement

Brazzelli¹,

Prestinari²,

Barbagallo³

et al. 2005

Pediatric Dermatology

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Thyroid diseases may be associated with a wide variety of dermatologic disorders. We report a 15-year-old girl with acquired ichthyosis and hypertrichosis associated with hypothyroidism resulting from autoimmune thyroiditis. Her skin lesions progressively resolved after 8 months of replacement therapy with L-thyroxine. This result supports the hypothesis that hypothyroidism in our patient can be directly related to the pathogenesis of acquired ichthyosis and hypertrichosis.

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“…AN is well known as a clinical marker of malignancy; however, most cases are related to metabolic or endocrinological diseases such as insulin-resistant diabetes mellitus, hypothyroidism, and obesity [1, 2, 3, 4, 5]. In some cases, autoimmune disorders such as systemic lupus erythematosus (SLE) and hypothyroidism complicated with type B insulin resistance were reported to be accompanied by AN [6, 7, 8, 9, 10, 11, 12]. …”

Section: Introductionmentioning

confidence: 99%

A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

et al. 2012

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Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjögren’s syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during a 10-year clinical course with benign diffuse papillomatosis extending from the mucosa of the larynx to the esophagogastric junction. The case was complicated with chronic thyroiditis and interstitial pneumonia, which were not treated with any medication. AN skin lesions and mucosal papillomatosis regressed with oral cyclosporine A, accompanied by the lowering of autoantibody titers. This is the first report of generalized AN involving an area from the mucosa of the larynx to the esophagogastric junction accompanied by autoimmune manifestations which responded to systemic immunosuppressive therapy.

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Remission of Acanthosis Nigricans, Hypertrichosis, and Hashimoto's Thyroiditis with Thyroxine Replacement

Cited by 14 publications

References 30 publications

Acanthosis nigricans: A review

Acanthosis nigricans: A review

Acquired Ichthyosis and Hypertrichosis due to Autoimmune Thyroiditis: Therapeutic Response to Thyroxine Replacement

A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

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