Remission Induced by a New Specific Oral Polymeric Diet in Children with Crohn�s Disease

Abstract

We have been able to show that CT3211 is an effective oral treatment in children with active Crohn's disease. It was well tolerated, and there were minimal side effects. At the mucosal site of disease there was macroscopic and histological improvement, together with evidence of downregulation of the pro-inflammatory cytokines IL-1 beta, IL-8, and IFN-gamma.

Growth factors from bovine milk and colostrum: composition, extraction and biological activities

“…This extract was also shown to be an effective oral treatment in children with active Chrohn's disease [54,55], leading to mucosal healing, together with down-regulation of the pro-inflammatory cytokines IL-1β, IL-8 and IFN-γ . Phylactos et al [159] have demonstrated that the antiinflammatory action of the extract cannot be related to increased activities of antioxidant metallo-enzymes involved in the disposition of superoxide radicals.…”

Milk growth factors as health products: Some technological aspects

“…The extract produced by Nestle was shown to be an effective oral treatment in children with active Crohn's disease (Fell et al, 1999(Fell et al, , 2000. This extract was also shown to improve pathological conditions of interleukin-10 knockout mice, as a model of inflammatory bowel diseases, supporting the implication of TGF-b2 in the observed beneficial effects (Oz, Ray, Chen, & McClain, 2004).…”

Chapter 5.1.4. Paediatric Immune–related Enteropathies

“…Once more, the London group by Walker‐Smith et al first reported the benefits of a special polymeric diet containing TGFbeta‐2 as efficient in promoting mucosal healing (35). With time and more frequent use of exclusive enteral nutrition, the Paris group confirmed the efficacy of EEN in CD not only by tube feeding, but also when taken orally (36).…”