Remission in juvenile-onset recurrent respiratory papillomatosis

Long Term Outcome Of Juvenile Onset Recurrent Respiratory Papillomatosis In Universiti Kebangsaan Malaysia Medical Centre

“…Papillomas can be found anywhere in the aerodigestive tract with the most common locations found at the junction of the squamous and ciliary epithelium and larynx. [2,3] In the present study, all the patients had glottis involvement. Other predominant sites were the limen vestibuli, the nasopharyngeal surface of the soft palate, the midzone of the laryngeal surface of the epiglottis, the upper and lower margins of the ventricle, the undersurface of the vocal folds, the carina and the bronchial spurs.…”

“…Recurrent respiratory papillomatosis caused by HPV types 6 and 11 is the most common benign neoplasm of the larynx. [1][2][3] The course of JORRP is unpredictable as some patients present with aggressive disease, requiring multiple surgical debulking and hospitalizations. It has been hypothesised that HPV is transmitted vertically from mother to neonate during passage through the birth canal.…”

“…Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human papilloma virus (HPV) types 6 and 11. [1][2][3] Patients presenting with this disease at 12 years of age or younger are diagnosed with juvenile-onset recurrent respiratory papillomatosis (JORRP). In the United States, the incidence rate of JORRP is reported as 4.3 per 100,000 children.…”

Exploring Recurrent Respiratory Papillomatosis: A Mini-Review

“…Generally, there are more than 100 subtypes of HPV [4,15,[22][23][24]. Majority of the available studies report the mean age at diagnosis of Juvenile Onset RRP to be 3.8 years while the adult form manifests normally in the 3rd or 4th decade of life and rarely manifests in those older than 60 years of age and the younger the patient's age at diagnosis, the more likely the patient will have severe disease [1,11,25]. The disease associated with HPV-11 is more severe and thus as many as about 70% require tracheostomy compared to 20% of those children afflicted with HPV-6 [1,3,26,27].…”