Remineralization effects of two pediatric dentifrices and one regular dentifrice on artificial carious lesion in primary teeth: An in vitro study

Advani, Shweta; Sogi, Suma; Hugar, Shivayogi M; Indushekar, K R; Kiran, Kamini; Hallikerimath, Seema

doi:10.4103/2231-0762.137627

Cited by 12 publications

(5 citation statements)

References 8 publications

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“…from using toothpaste when compared to the immediate salivary pH. It was in agreement with Advani and co-workers (Advani et al 2014) who evaluated the effect of different pediatric fluoride dentifrices on artificial carious lesions in primary teeth and they found that there was increase in salivary PH with using fluoride dentifrices. The decrease in salivary pH after 30 mins.…”

Section: 3stability Of Preparationssupporting

confidence: 87%

A Comparative study of the Clinical and Microbiological Effects of Fluoride, Xylitol and Combined Fluoride-Xylitol Toothpastes in Children

Hamad

Hazem

Mahfouz

et al. 2021

Records of Pharmaceutical and Biomedical Sciences

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The aim of our study was to evaluate and compare the clinical and microbiological efficiency of Fluoride, Xylitol and combined Fluoride -Xylitol toothpastes on some salivary parameters in children by measuring salivary pH, salivary flow rate, salivary Streptococcus mutans (S. mutans) and Lactobacillus counts. Toothpastes were prepared by mortar and pestle technique. They were then evaluated for physicochemical properties like pH, cleanability, physical appearance, spreadability, abrasiveness, foaming power, homogeneity, content of moisture and volatile substances, and drug content. Twenty one normal apparently healthy children were selected from the Outpatient Dental Clinic of Pedodontic Department, Faculty of Dentistry, Suez Canal University. Children were randomly divided into three groups: children who brushed their teeth with fluoride toothpaste, children who brushed their teeth with xylitol toothpaste and children who brushed their teeth with combined fluoride xylitol toothpaste. Salivary samples were obtained from all groups and examined for salivary parameter changes (flow rate, pH) and microbiological assessment for (S. mutans and Lactobacilli) was done. All data were collected, tabled and statistically analyzed. Statistical significance was measured using p value. Xylitol was superior in increasing salivary flow rate and decreasing mean of S. mutans when compared to fluoride while Fluoride was superior in decreasing mean of Lactobacilli when compared to xylitol. Both had the same effect on increasing salivary pH.

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Section: 3stability Of Preparationssupporting

confidence: 87%

A Comparative study of the Clinical and Microbiological Effects of Fluoride, Xylitol and Combined Fluoride-Xylitol Toothpastes in Children

Hamad

Hazem

Mahfouz

et al. 2021

Records of Pharmaceutical and Biomedical Sciences

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“…The onset of dental caries requires the establishments of necessary physiochemical conditions for mineral dissolution. [29] Certain chemical agents have the potential to modify this mineral loss caused by organic acids.…”

Section: Discussionmentioning

confidence: 99%

Remineralization potential of dentifrice containing nanohydroxyapatite on artificial carious lesions of enamel: A comparative in vitro study

et al. 2019

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Background:A carious lesion is the accumulation of numerous episodes of demineralization and remineralization, rather than a unidirectional demineralization process. Tooth destruction can be arrested or reversed by the frequent delivery of fluoride or calcium/phosphorous ions to the tooth surface. Nanohydroxyapatite particle-containing dentifrices are the newer generation of products which claim to remineralize enamel lesions effectively. The aim of this study was to evaluate and compare the remineralization ability of dentifrices containing nanohydroxyapatite, NovaMin, and amine fluoride on artificial enamel caries.Materials and Methods:In this in vitro study, extracted sound premolars were placed in a demineralizing solution to produce deep artificial carious lesions. The teeth were then sectioned longitudinally and divided into three groups (n = 16 in each group): Group A (nanohydroxyapatite), Group B (NovaMin), and Group C (fluoride). The sections were then subjected to pH cycling for 7 days. Polarized light microscopy was utilized to record the depth of the lesions before and after treatment with the selected dentifrices. Changes in the mean lesion depth were statistically analyzed by one-way ANOVA and t-test. The level of significance was assessed at P < 0.05.Results:The lesion depth decreased significantly by 10.56% in Group A, 6.73% in Group B, and 9.58% in Group C (paired t-test, P < 0.001). When comparisons were made across the groups, no statistical significance was found between the Groups A, B, and C (ANOVA test, P > 0.05).Conclusion:All three dentifrices were found to be effective in remineralizing artificial carious lesions. Nanohydroxyapatite dentifrice produced significantly better results compared to fluoride- and NovaMin-containing dentifrices, instigating for its use in the management of early carious lesions.

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“… 1 Various studies have shown CPP-ACP to decrease demineralization and enhance remineralization of the enamel surface carious lesions as well as remineralization of enamel subsurface lesions in various animal and human in situ trials. 5 …”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Two Remineralizing Agents on Artificial Carious Lesion Using DIAGNOdent

Arjun¹,

Bhat²,

Hegde³

et al. 2021

International Journal of Clinical Pediatric Dentistry

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A bstract Purpose The current in vitro study was conducted to assess the remineralization potential of CPP-ACP and a customized dentifrice (tricalcium-phosphate) on artificial carious lesions using DIAGNOdent. Materials and methods Fifty-one extracted premolars that satisfied the inclusion criteria were painted using acid-resistant nail varnish. A window of 4 × 4 mm was exposed on the center of the buccal surface of each tooth. After 20 minutes of drying, the baseline reading of enamel specimens was assessed using DIAGNOdent. The teeth were then immersed in a bath of demineralizing solution. An incubation period of 96 hours at 37°C resulted in artificial caries-like lesions on the specimen. Readings of the specimen within the window after demineralization were recorded using DIAGNOdent for all the samples. The specimens were divided into three groups randomly [group I—casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), group II—customized dentifrice, group III—artificial saliva]. Samples were subjected to the daily treatment regimen for a period of 30 days. The samples were evaluated for remineralization by laser fluorescent device (DIAGNOdent) on the 15th and 30th day, respectively. Results The statistical analysis was done using the Friedman test, Kruskal–Wallis test, Wilcoxon sign rank test, and Mann–Whitney test. The results showed that both CPP-ACP and customized dentifrice showed almost similar remineralization potential but CPP-ACP showed significant remineralization ( p < 0.001). Conclusion The DIAGNOdent observation conclusively proves that CPP-ACP and customized dentifrice remineralizes the demineralized tooth samples in vitro with CPP-ACP showing significant remineralization. How to cite this article Arjun DS, Bhat SS, Hegde SK, et al. Comparative Evaluation of Two Remineralizing Agents on Artificial Carious Lesion Using DIAGNOdent. Int J Clin Pediatr Dent 2021;14(2):192–195.

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Remineralization effects of two pediatric dentifrices and one regular dentifrice on artificial carious lesion in primary teeth: An in vitro study

Cited by 12 publications

References 8 publications

A Comparative study of the Clinical and Microbiological Effects of Fluoride, Xylitol and Combined Fluoride-Xylitol Toothpastes in Children

A Comparative study of the Clinical and Microbiological Effects of Fluoride, Xylitol and Combined Fluoride-Xylitol Toothpastes in Children

Remineralization potential of dentifrice containing nanohydroxyapatite on artificial carious lesions of enamel: A comparative in vitro study

Comparative Evaluation of Two Remineralizing Agents on Artificial Carious Lesion Using DIAGNOdent

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