Remineralization and Demineralization in situ from a Triclosan/Co-polymer/Fluoride Dentifrice

Abstract

An in situ study was conducted to evaluate the effect of a dentifrice containing 1100 ppm F (NaF) and triclosan, an anti-plaque agent, on remineralization of artificially-formed caries lesions in thin sections of human enamel. The thin sections were placed in mandibular partial dentures of 15 subjects and covered with a steel mesh to provide an area for plaque accumulation. The subjects brushed their teeth and dentures three times daily for two-week periods in a cross-over design, after which the specimens were removed and analyzed by quantitative microradiography for changes in mineral content. Results showed that lesions treated with the triclosan-fluoride product were remineralized 18.0 +/- 23.4% compared with 19.0 +/- 32.3% from a 1100-ppm F (NaF) positive control. Use of a placebo dentifrice resulted in 71.9% demineralization. The findings showed that triclosan neither enhanced nor interfered with the promotion of remineralization by fluoride.

Triclosan antimicrobial activity against dental-caries-related bacteria

“…However, it is believed that the FabV type enoyl acyl reductase carrier protein, which is also an isoenzyme present in the cell membrane of P. aeruginosa, confers resistance to TCS 20 . Thus, TCS can possibly be indicated for patients at high risk for caries due to its antimicrobial action against S. mutans observed in this study and its effectiveness as an adjuvant to fluoride and remineralization capacity already reported 14 . Although studies observed a decrease in dental plaque using toothpaste with triclosan 9,11,12 , no study has compared the caries incidence of patients using TCS with other agents.…”

“…In this context, TCS has been employed as an adjunct to fluoride. A study indicated that a dentifrice containing 0.3% of TCS was highly effective in preventing and enhancing demineralization compared to a positive control sodium fluoride dentifrice 14 .…”

Enhanced Anti-Bacterial Activity of Arachidonic Acid against the Cariogenic Bacterium Streptococcus mutans in Combination with Triclosan and Fluoride

“…Since many dental products contain fluoride, it was also important to investigate the compatibility of fluoride with AA and triclosan. A study by Mellberg et al [ 84 ] showed that triclosan does not interfere with fluoride-mediated remineralization, which is essential for the caries-inhibiting effect of fluoride. We observed here that fluoride enhanced the anti-bacterial effect of both AA ( Figure 3 A) and triclosan ( Figure 3 B), with improved anti-bacterial activity of the triple treatment ( Figure 3 C).…”

Дентин Кариесін Ауа Абразивті Әдісін Қолдану

“…[1,2]. Себебі тіс жарудан кейін бірден тістің қатты тіндері толығымен минералданбайды, эмаль кеңейтілген призмааралық кеңістіктермен сипатталады, олар "піскен" тістерге қарағанда 2,0-2,5 есе үлкен, тіс сұйықтығының микроциркуляторлық негізгі көлемі ұлғаяды және дентинде гипоминерализация аймақтары көрінеді [3][4][5]. Көбінесе жағдайды нашарлатады ауыз қуысының гигиенасы және мінез-құлық пен тамақтану режимінің бұзылуы (жас балаларда бұл бір жылдан кейін, әсіресе түнде, бөтелкедегі тәттілендірілген сұйықтықтармен немесе емшек сүтімен емізу; егде жастағы балаларда-тәттілерді жиі қолдану) [6].…”