Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc

Diering, Graham H.

doi:10.1016/j.ynstr.2022.100512

Cited by 6 publications

(6 citation statements)

References 132 publications

(233 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Along with that, synapses contain reduced amounts of GluA1, particularly phosphorylated GluA1, and GluN2A, without a reduction in GluA3 or GluN2B after sleep compared with wakefulness 151,152 . These effects of sleep on synapses show an overall net decrease in LTP, and potentially a net increase in depotentiation, and are in line with the hypothesis that sleep promotes a global homoeostatic downscaling of synapses after a wakeful period full of LTP-like activity 10,153 .…”

Section: Synaptic Plasticity During Sleepsupporting

confidence: 86%

Overnight neuronal plasticity and adaptation to emotional distress

Cabrera,

Koymans,

Poe

et al. 2024

Nat. Rev. Neurosci.

View full text Add to dashboard Cite

General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the KNAW public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain.• You may freely distribute the URL identifying the publication in the KNAW public portal. Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

show abstract

Section: Synaptic Plasticity During Sleepsupporting

confidence: 86%

Overnight neuronal plasticity and adaptation to emotional distress

Cabrera,

Koymans,

Poe

et al. 2024

Nat. Rev. Neurosci.

View full text Add to dashboard Cite

show abstract

“…To extend our findings from dendritic spine morphology, we explored the requirement for miR-218-5p activity in mediating alterations in post-synaptic proteins after HSD induction. The reduction in cluster number and size of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) subunits, GluA1 and GluA2, is a well-established mechanism in HSD (20, 22). To investigate the potential direct or indirect role of miR-218-5p in downregulating GluA2 and GluA1 clusters during HSD, we conducted surface immunostaining in hippocampal neurons co-transfected with GFP and LNA218 (Figure 2C).…”

Section: Resultsmentioning

confidence: 99%

“…From a physiological perspective, visual sensory deprivation results in homeostatic upscaling of excitatory synapses in the visual cortex during development (18,19). In contrast, homeostatic synaptic downscaling has emerged as an important component of sleep-dependent memory consolidation (20)(21)(22). Analogous to human EEG recordings, distinct frequency patterns characterize brain activity in rodents during different sleep stages.…”

Section: Introductionmentioning

confidence: 99%

microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity

Colameo,

Maley,

ElGrawani

et al. 2023

Preprint

View full text Add to dashboard Cite

Homeostatic synaptic plasticity (HSP) is a fundamental neuronal mechanism that allows networks to compensate for prolonged changes in activity by adjusting synaptic strength. This process is crucial for maintaining stable brain function and has been implicated in memory consolidation during sleep. While scaling of both excitatory and inhibitory synapses plays an important role during homeostatic synaptic plasticity, molecules coordinating both of these processes are unknown. In this study, we investigate the role of miR-218-5p as a regulator of inhibitory and excitatory synapses in the context of picrotoxin (PTX)-induced homeostatic synaptic downscaling (HSD) in rat hippocampal neurons. Using enrichment analysis of miRNA-binding sites in differentially expressed genes changing upon PTX-induced HSD, we bioinformatically predicted and experimentally validated increased miR-218-5p activity upon PTX-treatment in the process compartment. By monitoring synapse structure in vitro with confocal microscopy, we demonstrate that inhibiting miR-218-5p activity exerts a dual effect during HSD: it prevents the downscaling of excitatory synapses and dendritic spines, while at the same time blocking inhibitory synapse upscaling. Furthermore, we identify the Neuroligin2 interacting molecule Mdga1 as a crucial target of miR-218-5p in the context of homeostatic upscaling of inhibitory synapses. By performing long-term electroencephalographic (EEG) recordings, we further revealed that local inhibition of miR-218-5p in the somatosensory cortex reduced local slow-wave activity (SWA) during non-rapid-eye-movement (NREM) sleep. In summary, this study uncovers miR-218-5p as a key player in coordinating inhibitory and excitatory synapses during homeostatic plasticity and sleep. Our findings contribute to a deeper understanding of how neural circuits maintain stability in the face of activity-induced perturbations, with potential implications for both physiological and pathological conditions.

show abstract

“…Without enough sleep, the ability to perform even simple tasks, such as substituting one symbol for another or recognizing letters, dramatically declines 32. Without adequate sleep, the brain's ability to consolidate information is diminished through decreased long-term potentiation of neuronal synaptic strength, which is associated with learning and memory 33,34. Being less alert, attentive, and unable to concentrate effectively has obvious implications for nurses providing patient care 35…”

Section: Functions Of Sleepmentioning

confidence: 99%