Overnight neuronal plasticity and adaptation to emotional distress

Abstract

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Aversive memories can be weakened during human sleep via the reactivation of positive interfering memories

“…Considering the influence of REM sleep on TMR and emotional memory (Cabrera et al, 2024; Batterink et al, 2017; Goldstein & Walker, 2014; Groch et al, 2013; Tamminen et al, 2017), we explored the relationship between REM parameters (percentage and REM-theta power) and behavioral measures (recall, intrusion, and positivity change scores). Consistent with previous analyses, we first combined the behavioral outcomes from the immediate and delayed tests.…”

“…Future research should explore ways to introduce positive interfering memories (Bjork et al, 1998), such as positive autobiographical memories or therapy-related memories (Speer et al, 2021; Schwartz et al, 2022), to effectively weaken real-life trauma memories. Second, the role of REM sleep in modulating emotional memories shall be further investigated (Cabrera et al, 2024; Goldstein & Walker, 2014). Our TMR was administered during SWS, a sleep stage that is critical for memory reactivation and systems consolidation (Klinzing et al, 2019; Hu et al, 2020; Wilson et al, 1994).…”

REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals

“…The mechanisms underlying REM alterations in PTSD and, by extension, how they might be associated with impaired extinction recall are not clear. However, it was proposed that hyperarousal, characterized by impairment in the inhibitory control of amygdala activity by the medial PFC (mPFC) with a concomitant increase in noradrenergic activity, contributes to REM dysregulation (Cabrera et al 2024; Germain et al 2008; Pace-Schott et al 2015b; Pace-Schott et al 2023). Indeed, increased REMD may be a direct manifestation of hyperarousal in PTSD (Barbato 2023).…”

A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses

“…We are particularly interested in the neural mechanisms that underpin these mechanisms, such as the role of neural circuits and their plasticity in cognitive responses [7][8][9][10][11]. By investigating neural activity and connectivity, we hope to gain insight into brain adaptation [12][13][14].…”