Abstract:With much interest we read the paper by Antoniou and colleagues (British Journal of Cancer, October 18, p 1580). These researchers described the development of a genetic model for familial breast cancer, named BOADICEA, which takes into account the simultaneous effects of BRCA1, BRCA2 and other genes. There is a considerable need for such predictions for purposes of management of women referred to genetic clinics and for the considerations of eligibility of any prophylactic interventions in both the clinical a… Show more
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