Neill KM. A review of atypical clinical manifestations of acute myocardial infarction. J Intensive Care Med 1987;2:25-32.This review describes pertinent demographic and illness characteristics of patients who are seen with atypical symptoms of acute myocardial infarction. The determination of psychosocial, behavioral, and environmental patterns of patients complaining of chest discomfort adds important information to the clinical assessment of chest pain. Systematic information about the pain and other symptoms of acute myocardial infarction and about the variables that influence these symptoms can assist practitioners as well as sufferers of myocardial pain to resolve the uncertainty surrounding it.From the Address reprint requests to Dr Neill.Despite recent dramatic declines in coronary mortality, coronary heart disease (CHD) remains the primary cause of death in the United States. The main symptom of CHD is chest pain masked in many forms and minimized by many victims. Of the estimated 1.5 million Americans who will have a myocardial infarction in 1987, over one-third will die that same year. Of those who die of acute myocardial infarction (AMI), 62% never reach the hospital. The average victim waits three hours before seeking assistance [1]. This review includes discussions of studies of clues and disguises of AMI. A better understanding of the early clues of AMI could result in faster recognition of myocardial pain by the victim. Earlier recognition by the victim could lead to less delay in seeking treatment, less myocardial ischemic damage, and, consequently, fewer deaths from coronary heart disease.In an attempt to reduce health care costs by decreasing the number of unnecessary admissions to coronary care units (CCUs) and identifying appropriate candidates for early discharge, efforts are being made to increase the reliability of diagnoses regarding myocardial pain [2][3][4]. Understanding the significance of chest pain is as difficult for the clinician as it is for the patient [5]. In one six-month survey of 588 patients admitted to an emergency room for chest pain, 85 different diagnoses were obtained [6].To make a quick and accurate clinical diagnosis of myocardial infarction or ischemia, medical personnel have been increasingly more reliant on laboratory data and electrocardiograms (ECGs). Reliance on technical data for diagnosis of AMI, however, is not without its problems. In a retrospective study of 100 autopsy-proved acute myocardial infarctions, 47% were not diagnosed [7]. This failure rate had not improved on that of studies conducted several decades ago. The physician-