With increased use, complexity, and miniaturization of electronics in various applications, there is a need to improve the reliability of electronic products swiftly and cost-effectively. The shift from the use of traditional constant failure rate approaches to estimate the reliability of electronic products was enabled by physics-of-failure based reliability approaches. In a physics-offailure based reliability assessment, the failure mechanisms that degrade products and ultimately produce failures are identified, based on the hardware configuration and anticipated life-cycle profile. Physics-of-failure models associated with specific failure mechanisms are utilized to provide a statistical distribution of the time-to-failure for a particular failure mechanism and site. Physics-of-failure based reliability assessment is integrated into the product development process to aid in design-forreliability, stress test selection, product qualification, product screening, and prognostics and health management. This paper describes various steps involved in the physics-of-failure based reliability of electronic products and its integration into the product development process.