In this paper, we fabricated a W/Al 2 O 3 /Ti metal-insulator-metal (MIM) antifuse one-time programmable memory. A large current overshoot was observed during the dielectric breakdown, which generated a strong conductive filament and resulted in extremely low on-state resistance. The performance of this Al 2 O 3 -based antifuse has been demonstrated with an ultra large ON/OFF window on the order of 10 12 . Both breakdown voltage and on-state resistance exhibit excellent uniformity, the off-state lifetime is projected to be 1591 years at 2 V, and the on-state exhibits a reliable filament that is difficult to rupture.