Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy

Hafez, Nesreen H.; Tahoun, Neveen

doi:10.1016/j.jnci.2011.09.009

Cited by 105 publications

(113 citation statements)

References 22 publications

(28 reference statements)

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“…In the present study, SCC was the most common metastatic tumor followed by adenocarcinoma and poorly differentiated carcinoma. Similar findings were reported in other studies (Ahmad et al, 2005;Khajuria et al, 2006;Hafez et al, 2011). In contrast, other study (Ghartimagar et al, 2011) found adenocarcinoma to be the most common tumor to metastize lymph nodes followed by SCC.…”

Section: Discussionsupporting

confidence: 89%

“…The value of FNAC besides making a diagnosis also lies in early direction of appropriate investigations (Khajuria et al, 2006). The frequency of metastatic lymphadenopathy was observed to be low, 3.8% and 8.7% in some studies (Khajuria et al, 2006;Fatima et al, 2011) whereas, a higher incidence of 19.7 % and 24.7% was reported by other studies (Hafez et al, 2011, Ageep et al, 2012 respectively. However, in the current study, metastatic lymphadenopathy contributed to 31.3% of lymphadenopathies.…”

Section: Discussionmentioning

confidence: 88%

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Metastatic Lymphadenopathy in Kashmir Valley: A Clinicopathological Study

Qadri¹,

Hamdani²,

Shah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Lymphadenopathy is a common presentation in both benign and malignant diseases which need to be diagnosed without delay. Fine needle aspiration cytology (FNAC) helps us diagnose a disease and follow its course, including the response to therapy. Aim: This study aimed to analyze the clinicopathological features of metastatic lymphadenopathy and the diagnostic utility of FNAC in our setting. Materials and Methods: This two-year prospective study included all the patients with metastatic lymphadenopathy, diagnosed with FNAC. Results: A total of 412 cases (male:female ratio, 1.3:1; age range, 3 to 90 years) were studied. Supraclavicular lymph nodes were involved most commonly (50.5%). The commonest metastatic tumor was squamous cell carcinoma in general (30.1%) and in males (37.6%), and infiltrating ductal carcinoma (25.3%) in females. Lung, with 64 (15.5%) cases followed by esophagus, 60 (14.6%) cases; breast, 49 (11.9%) cases; skin, 32 (7.8%) cases; and stomach, 25 (6.1%) cases were the most common primary sites of malignancy. In 69 patients, excision biopsy was performed. Histopathological findings correlated well with that of cytology in all these cases. Conclusions: FNAC is an important tool in the diagnostic work up of metastatic lymphadenopathy, which in the hands of an experienced and skilful cytopathologist can avoid the need for excision biopsy.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 88%

Metastatic Lymphadenopathy in Kashmir Valley: A Clinicopathological Study

Qadri¹,

Hamdani²,

Shah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…CLN enlargement includes a certain frequency of various types of malignant disease. The percentages of patients with malignant disease in reports that analyzed FNA cytology of CLN ranges from 46% to 69.4% 7, 11, 23. Our combined results of CS cytology and LBC showed a similar rate of 50.1% of 165 patients analyzed with malignant disease.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of liquid‐based cytology with fine needle aspiration specimens for cervical lymphadenopathy

Bandoh

Goto

Akahane

et al. 2016

Diagnostic Cytopathology

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BackgroundCervical lymphadenopathy is a symptom that is frequently seen among outpatients, and it is important to differentiate malignant lesions from reactive lymphoid hyperplasia. Fine needle aspiration (FNA) cytology has been widely used for the diagnosis of cervical lymphadenopathy. However, some limitations of the diagnostic accuracy using conventional smear (CS) cytology have been pointed out. The diagnostic value of liquid‐based cytology (LBC) with FNA specimens has not yet been fully proven.MethodsForty‐two patients with cervical lymphadenopathy who underwent FNA with CS cytology from 2007 to 2011 and 123 patients who underwent FNA with LBC utilizing LBCPREP2™ from 2011 to 2015 were studied. Diagnostic values were compared between the CS and the LBC groups.ResultsOf the total 165 patients representing the combined CS and LBC groups, 81 (49.1%) were diagnosed as benign lymph node and 84 (50.9%) were malignant diseases including 37 (22.4%) of metastatic carcinoma except for thyroid carcinoma, 30 (18.2%) of metastatic thyroid carcinoma, and 17 (10.3%) of malignant lymphoma. The overall statistical values including sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the CS were 75%, 100%, 100%, 78.9%, and 87.1%, respectively, whereas those values for LBC were 91.2%, 100%, 100%, 90.7%, and 95.3%, respectively. The sensitivity of LBC for malignant diseases tended to be higher than that of CS cytology (p = 0.081).ConclusionLBC with FNA specimens from cervical lymphadenopathy is a useful and reliable method for the diagnosis of malignant diseases, especially of metastatic carcinomas, due to its increased sensitivity compared with CS cytology. Diagn. Cytopathol. 2016;44:169–176. © 2016 Wiley Periodicals, Inc.

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“…FNAC of lymph node has become an integral part of the initial diagnosis and management of patients with lymphadenopathy due to early availability of results, simplicity, and, minimal trauma with less complication. FNAC has also been advocated as a useful method in comparison to more expensive surgical excision biopsies in developing countries with limited financial and health care resources (Hafez et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…It is one of the commonest and significant clinical presentations of patients, attending the outdoor clinics in most hospitals. The aetiology varies from an inflammatory process to a malignant condition (Hafez et al, 2011). For assessment of lymphadenopathy, different modalities are used which include FNAC, automatic core needle biopsy, flow cytometry, radiologically guided core needle biopsy and open biopsy.…”

Section: Introductionmentioning

confidence: 99%

Profile of Lymphadenopathy in Kashmir Valley: a Cytological Study

Qadri

Hamdani²,

Shah³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Lymphadenopathy is one of the commonest and significant manifestations of local as well as systemic ailments, especially malignancies. Fine needle aspiration cytology (FNAC) helps in diagnosing the disease itself, in general, but more importantly ruling out malignancy, in particular. Hence it saves much of the cost and use of resources incurred with excision biopsy of such lymph nodes. This prompted us to study the cytologic patterns of lymphadenopathy in our setting and the diagnostic utility of FNAC in the evaluation of lymphadenopathy. In this retrospective observational study, 1,579 patients (953 males and 626 females) with lymphadenopathy who were subjected to FNAC over a period of three years (January 2009 to December 2011) were studied. The cervical region was involved in most of the cases (76%) followed by the axillary region (17.5%). Metastatic malignancy (38.2%) was the commonest cause of lymphadenopathy followed by reactive lymphoid hyperplasia (36.9%), tuberculosis (9.1%) and lymphomas (8.6%). Squamous cell carcinoma (32.2%) followed by adenocarcinoma (21.9%) were the most frequent metastatic tumors. FNAC is a useful diagnostic tool in the management of patients presenting with lymphadenopathy and should be considered before more invasive and costly procedures are performed, particularly in developing countries.

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Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy

Cited by 105 publications

References 22 publications

Metastatic Lymphadenopathy in Kashmir Valley: A Clinicopathological Study

Metastatic Lymphadenopathy in Kashmir Valley: A Clinicopathological Study

Diagnostic value of liquid‐based cytology with fine needle aspiration specimens for cervical lymphadenopathy

Profile of Lymphadenopathy in Kashmir Valley: a Cytological Study

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