Reliability of bedside ABO testing before transfusion

Migeot, Virginie; Ingrand, Isabelle; Salmi, Louis Rachid; Ingrand, Pierre

doi:10.1046/j.1537-2995.2002.00219.x

Cited by 26 publications

(22 citation statements)

References 29 publications

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“…Bedside testing performed immediately prior to transfusion can prevent this complication [4] and is therefore required by law in many countries. The critical issue in bedside testing for ABO compatibility is the accuracy of the test and its interpretation, depending markedly on correct use of the device [15,16]. As could be shown recently, high rates of erroneous transfusion decisions were due to defective techniques and poor user performance [14,16].…”

Section: Discussionmentioning

confidence: 99%

“…The critical issue in bedside testing for ABO compatibility is the accuracy of the test and its interpretation, depending markedly on correct use of the device [15,16]. As could be shown recently, high rates of erroneous transfusion decisions were due to defective techniques and poor user performance [14,16]. Some reports have been published to introduce new bedside test cards [17][18][19]23], but only a few studies compared different card systems [6,19].…”

Section: Discussionmentioning

confidence: 99%

“…Lack of transfusion experience was considered important as experience with a given test system/product may provoke a bias towards the known type. Furthermore, the risk of erroneous detection of agglutination is reported to decrease with increasing transfusion experience [16,20,21,24] although inexperienced users must also be sure of their test results. Overall, all cards received good marks and matched the given ABO blood group correctly.…”

Section: Discussionmentioning

confidence: 99%

“…4, is crucial for correct test interpretation [19,20]. All features that facilitate the procedure and improve the detection of agglutination may reduce the risk of error [16], particularly in inexperienced investigators. Therefore, the inferiority of card no.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, if bedside testing had been performed correctly in each case, 7 of 8 ABO-incompatible transfusions diagnosed at the Charité University Hospital in Berlin, Germany, between January 1997 and December 2004 would have been prevented [14]. As a consequence this test needs, apart from valid results, easy conduction and design to ensure accurate performance and correct use being crucially important for correct test interpretation [15,16]. Despite this, comparative data of different bedside techniques due to different card designs (e.g.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety

Giebel¹,

Picker²,

Gathof³

2007

Transfus Med Hemother

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Objective: Pretransfusion ABO compatibility testing is a simple and required precaution against ABO-incompatible transfusion, which is one of the greatest threats in transfusion medicine. While distinct agglutination is most important for correct test interpretation, protection against infectious diseases and ease of handling are crucial for accurate test performance. Therefore, the aim of this study was to evaluate differences in test card design, handling, and user safety. Design: Four different bedside test cards with pre-applied antibodies were evaluated by 100 medical students using packed red blood cells of different ABO blood groups. Criteria of evaluation were: agglutination, labelling, handling, and safety regarding possible user injuries. Criteria were rated subjectively according to German school notes ranging from 1 = very good to 6 = very bad/insufficient. Results: Overall, all cards received very good/good marks. The ABO blood group was identified correctly in all cases. Three cards (no. 1, no. 3, no. 4) received statistically significant (p < 0.008) prominence (mean values shown) concerning clearness of agglutination (1.7-1.9 vs. 2.4 for no. 2). Systems with dried antibodies (no. 2, no. 4) outmatched the other systems with respect to overall test system performance (2.0 vs. 2.8-2.9), labelling (1.5 vs. 2.2-2.4), handling (1.9-2.0 vs. 2.5), and user safety (2.5 vs. 3.4). Analysis of card self-explanation revealed no remarkable differences. Conclusion: Despite good performance of all card systems tested, the best results when including all criteria evaluated were obtained with card no. 4 (particularly concerning clear agglutination), followed by cards no. 2, no. 1, and no. 3.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety

Giebel¹,

Picker²,

Gathof³

2007

Transfus Med Hemother

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Unerwünschte Transfusionswirkungen

Walther-Wenke¹

2003

Transfusionspraxis

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An integrated fiberoptic–microfluidic device for agglutination detection and blood typing

Ramasubramanian

Alexander

2008

Biomed Microdevices

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In this paper, an integrated fiberoptic-microfluidic device for the detection of agglutination for blood type cross-matching has been described. The device consists of a straight microfluidic channel through with a reacted RBC suspension is pumped with the help of a syringe pump. The flow intersects an optical path created by an emitter-received fiber optic pair integrated into the microfluidic device. A 650 nm laser diode is used as the light source and a silicon photodiode is used to detect the light intensity. The spacing between the tips of the two optic fibers can be adjusted. When fiber spacing is large and the concentration of the suspension is high, scattering phenomenon becomes the dominant mechanism for agglutination detection while at low concentrations and small spacing, optointerruption becomes the dominant mechanism. An agglutination strength factor (ASF) is calculated from the data. Studies with a variety of blood types indicate that the sensing method correctly identifies the agglutination reaction in all cases. A disposable integrated device can be designed for future implementation of the method for near-bedside pre-transfusion check.

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Reliability of bedside ABO testing before transfusion

Abstract: Although the experts considered Vu-Test to be better than Safety-Test ABO, error rates were high with both devices.

Cited by 26 publications

References 29 publications

Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety

Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety

Unerwünschte Transfusionswirkungen

An integrated fiberoptic–microfluidic device for agglutination detection and blood typing

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