Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety

Giebel, Felix; Picker, Susanne M.; Gathof, Birgit

doi:10.1159/000111385

Cited by 12 publications

(10 citation statements)

References 18 publications

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“…Traditional, simple and cheap ABO-Rh typing, utilizing commercial antisera, can be easily done at the bedside by trained health workers. Dry-reagent typing cards have been marketed for decades and offer an even more simplified typing procedure suitable for bedside blood group confirmation by ward staff [72,73]. Innovative paper based blood typing kits are also in the pipeline [74].…”

Section: Pre-transfusion Testingmentioning

confidence: 99%

Point of Care Testing and Transfusion Safety in Resource Limited Settings: A Review

Musi¹

2015

J Blood Disord Transfus

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Worldwide, one of the fastest growing aspects of clinical laboratory testing is point of care testing (POCT). Decentralized patient care and access to testing in under-served areas are key elements in the evolving expansion of POCT. Several available POCT devices can potentially contribute to safer transfusion practices in resourcelimited settings. Only "rapid diagnostic tests" and some simple hemoglobinometers are normally encountered in the peripheral hospitals of low income countries. Strengths, weaknesses and barriers of large scale utilization of POCT in transfusion medicine are discussed.

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Section: Pre-transfusion Testingmentioning

confidence: 99%

Point of Care Testing and Transfusion Safety in Resource Limited Settings: A Review

Musi¹

2015

J Blood Disord Transfus

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“…212 There are further blood group assays in paper-based card formats from other companies that have proven feasible in clinical environment. 213 Lateral flow assays, 214 however, do not require specific microfluidic handling. Typical examples for lateral flow assays comprise qualitative or semi-quantitative detection of mycotoxins in food and feed, 215 antigens of the hepatitis C virus 216 and antibodies of the human immunodeficiency virus.…”

Section: Immunoassaysmentioning

confidence: 99%

Lab-on-a-Foil: microfluidics on thin and flexible films

et al. 2010

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This critical review is motivated by an increasing interest of the microfluidics community in developing complete Lab-on-a-Chip solutions based on thin and flexible films (Lab-on-a-Foil). Those implementations benefit from a broad range of fabrication methods that are partly adopted from well-established macroscale processes or are completely new and promising. In addition, thin and flexible foils enable various features like low thermal resistance for efficient thermocycling or integration of easily deformable chambers paving the way for new means of on-chip reagent storage or fluid transport. From an economical perspective, Lab-on-a-Foil systems are characterised by low material consumption and often low-cost materials which are attractive for cost-effective high-volume fabrication of self-contained disposable chips. The first part of this review focuses on available materials, fabrication processes and approaches for integration of microfluidic functions including liquid control and transport as well as storage and release of reagents. In the second part, an analysis of the state of Lab-on-a-Foil applications is provided with a special focus on nucleic acid analysis, immunoassays, cell-based assays and home care testing. We conclude that the Lab-on-a-Foil approach is very versatile and significantly expands the toolbox for the development of Lab-on-a-Chip solutions.

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“…The errors were attributed to poor technique of the operator, device failure, or incorrect interpretation. Finally, the protection of the operator [ 11 ] and the cost of the PBCT device [ 12 ] were also important criteria to consider.…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips

2018

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Pre-transfusion bedside compatibility test is mandatory to check that the donor and the recipient present compatible groups before any transfusion is performed. Although blood typing devices are present on the market, they still suffer from various drawbacks, like results that are based on naked-eye observation or difficulties in blood handling and process automation. In this study, we addressed the development of a red blood cells (RBC) agglutination assay for point-of-care blood typing. An injection molded microfluidic chip that is designed to enhance capillary flow contained anti-A or anti-B dried reagents inside its microchannel. The only blood handling step in the assay protocol consisted in the deposit of a blood drop at the tip of the biochip, and imaging was then achieved. The embedded reagents were able to trigger RBC agglutination in situ, allowing for us to monitor in real time the whole process. An image processing algorithm was developed on diluted bloods to compute real-time agglutination indicator and was further validated on undiluted blood. Through this proof of concept, we achieved efficient, automated, real time, and quantitative measurement of agglutination inside a passive biochip for blood typing which could be further generalized to blood biomarker detection and quantification.

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Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety

Cited by 12 publications

References 18 publications

Point of Care Testing and Transfusion Safety in Resource Limited Settings: A Review

Point of Care Testing and Transfusion Safety in Resource Limited Settings: A Review

Lab-on-a-Foil: microfluidics on thin and flexible films

Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips

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