Reliability of a New Non-invasive Tear Film Break-up Time Measurement Using a Keratograph

Jeong, Seongyong; Lee, Sang Bumm

doi:10.3341/jkos.2016.57.9.1354

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…NIKf-BUT was used in this study and the mean NIKf-BUT was 5.8 ± 2.0 seconds, which was longer than the FBUT, which was 5.2 ± 2.3 seconds. However, previous studies showed that the NIKBUT is shorter than the FBUT because software analysis of NIKBUT may detect very early tear film changes and heat from the LED (light emitting diode) may induce more tear break-ups [8,10,11]. In this study, the examiner subjectively measured the FBUT and did not use a stopwatch, which might have influenced these conflicting results.…”

Section: Discussionmentioning

confidence: 89%

Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Lee

Kim

Choe

et al. 2020

Korean J Ophthalmol

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To evaluate the clinical symptoms of patients with dry eyes, based on the ocular surface disease index (OSDI) and analyze the relationship between OSDI and various ocular surface parameters. Methods: This was a retrospective study that included 45 eyes of 45 dry eye patients who visited the Seoul Nune Eye Hospital from August 2017 to December 2017. The patients were assessed by non-invasive keratography for the first break-up time, lipid layer thickness (LLT), tear osmolarity, tear matrix metalloproteinase-9 immunoassay as well as with the conventional Schirmer I test and fluorescein break-up time. The patient's symptoms were evaluated by the OSDI questionnaires and correlations were analyzed based on the parameters described above. Results: There were significant negative correlations between OSDI and non-invasive keratography for the first break-up time (p = 0.038, r =-0.330), and LLT (p = 0.005, r =-0.426). However, there were no significant correlations between OSDI and fluorescein break-up time, Schirmer I score, and tear osmolarity (p = 0.173, 0.575, and 0.844 respectively). OSDI was not significantly different between matrix metalloproteinase-9 positive and negative groups (p = 0.768). Conclusions: Non-invasive examinations such as non-invasive keratograph break-up time and interferometry of LLT can be efficient tools for evaluating dry eye symptoms.

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Section: Discussionmentioning

confidence: 89%

Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Lee

Kim

Choe

et al. 2020

Korean J Ophthalmol

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“…TBUT <5 seconds was considered as severe dry eye, between 5–10 seconds as dry eye, and >10 seconds considered as normal. [ 8 , 9 ]…”

Section: Methodsmentioning

confidence: 99%

Study of tear function before and after laser-assisted in-situ keratomileusis

Singh

Shukla

Garkal

et al. 2023

Indian Journal of Ophthalmology

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Purpose: This work assesses the change in tear function after LASIK surgery. Methods: This prospective, observational study was conducted in the Refractive Clinic of a tertiary care rural hospital. Tear dysfunction symptoms and the tear function tests were assessed in 269 eyes of 134 patients, OSDI score was used to document the tear dysfunction symptoms. Tear function was assessed by tear meniscus height, tear film break-up time (TBUT), Lissamine green staining, corneal fluorescein staining, Schirmer test 1 without anesthesia before and at 4–6 weeks and 10–12 weeks after LASIK surgery. Results: Preoperatively OSDI score was 8.54 ± 7.71. It increased to 15.11 ± 9.18 postoperatively at 4–6 weeks after LASIK surgery and 13 ± 9.56 at 10–12 weeks after LASIK surgery Mean TBUT preoperatively was 7.82 ± 3.57 sec which decreased to 5.34 ± 2.56 sec at 4–6 weeks and to 4.53 ± 2.63 sec at 10–12 weeks postoperatively. The number of eyes with clear secretion decreased from 40.5% preoperatively to 23.4% at 4–6 weeks and to 22.3% at 10–12 weeks postoperatively, whereas the granular and cloudy secretions increased significantly in eyes after LASIK surgery. The prevalence of eyes with Lissamine green score >3 (dry eye) increased from 17.1% preoperatively to 27.9% at 4–6 weeks and to 30.5% at 10–12 weeks. Similarly, the number of eyes showing positive fluorescein corneal staining increased from 5.6% preoperatively to 19% postoperatively at 4–6 weeks. Mean Schirmer score was 28.83 ± 6.39 mm preoperatively, 22.47 ± 5.38 mm at 4–6 weeks, and 21.27 ± 4.99 mm at 10–12 weeks after LASIK surgery. Conclusion: The prevalence of dry eye increased after LASIK as was assessed by an increase in the tear dysfunction symptoms using OSDI score and the deranged values of various tear function tests after LASIK surgery.

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“…Several causes contribute to the onset of dry eye symptoms after cataract surgery. The most important of them are decrease tear film breakup time due to surface irregularity at the site of the incision, prolonged use of antibiotic-steroid eye drops, poor tear film production and stability due to surgically induced ocular inflammation, decrease corneal sensation due to surgical incision which disrupts the cornea-lacrimal gland loop leading to reduced tear secretion, and exposure to light from the operating microscope [7,11,12] Various measurements are used to assess the incidence and severity pattern of dry eye syndrome among patients who have undergone phacoemulsification and extracapsular cataract extraction; such as: Schirmer tests, Invasive break up time test (IBUT) using fluorescein stain, and non-invasive break up time test (NIBUT) measured through video-keratography [13,14].…”

Section: Introductionmentioning

confidence: 99%

Ocular Surface Alterations Related to Cataract Surgery

Mohamed,

Nassar²,

Elsoht³

et al. 2023

JAMMR

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Background: Dry eye syndrome is a multifactorial disease of pre-corneal tear film that results in ocular discomfort, visual disturbance and tear film instability, with potential damage to the ocular surface. The aim of the work was to evaluate the ocular surface alterations related to cataract surgery either phacoemulsification or extracapsular cataract extraction surgeries. Methods: This prospective observational study included 60 patients with cataract. Patients were divided into 2 equal groups: Group1 included patients who had scheduled for phacoemulsification. Group 2 included patients who had scheduled for extracapsular cataract extraction surgery. All patients were subjected to full history taking, complete ophthalmic evaluation, OSDI score test, Schirmer tests, invasive break up time tests (IBUT), and non- invasive break up time tests (NIBUT). Results: Postoperative BCVA test in both groups was significantly better compared to preoperative tests after 1 week, 1 month, and 3 months while postoperative Schirmer test, IBUTT test, non IBUTT test, and OSDI test were significantly worse compared to preoperative in both groups after 1 week, 1month and 3 months (P value = 0.05). Conclusions: Patients who had scheduled for phacoemulsification showed a significantly better BCVA test, OSDI test, Schirmer test, IBUTT test, and non IBUTT test after 1 week, 1month and 3 months compared to extracapsular cataract extraction group.

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Reliability of a New Non-invasive Tear Film Break-up Time Measurement Using a Keratograph

Cited by 8 publications

References 17 publications

Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Study of tear function before and after laser-assisted in-situ keratomileusis

Ocular Surface Alterations Related to Cataract Surgery

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