Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer’s Disease

Cui, Yue; Dai, Shenyu; Miao, Zu-Pei; Zhong, Yu; Yang, Liu; Liu, Lin; Jing, Donglai; Bai, Yanyan; Kong, Yu; Sun, Wei; Li, Fang; Guo, Qihao; Rosa‐Neto, Pedro; Gauthier, Serge; Wu, Liyong

doi:10.3233/jad-190113

Cited by 31 publications

(43 citation statements)

References 33 publications

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“…MBI was assessed using the Chinese version of MBI-C developed by Cui [59], a scale established specifically for the community elderly with independent function. The MBI-C [42] includes 34 items classified as five domains: 1) decreased motivation (apathy); 2) emotional dysregulation (symptoms of mood and anxiety disorders); 3) impulse dyscontrol (impulsivity, aggression and agitation); 4) social inappropriateness (impaired social cognition); and 5) abnormal perception or through content (psychotic symptoms, i.e.…”

Section: Neuropsychiatric and Neuropsychological Assessmentmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

et al. 2020

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Background Frailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a dementia risk syndrome characterized by later-life emergence of persistent neuropsychiatric symptoms, has yet to be elucidated. We aimed to evaluate the associations between MBI and frailty in older adults without dementia. Methods In this cross-sectional study, a consecutive series of 137 older adults without dementia in the Anti-Aging Study, recruited from primary care clinics, were enrolled. Frailty was estimated using the Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist (MBI-C) at a cut-off point of > 8. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariable logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status. Results At baseline, 30.7% of the older adults had frailty and 18.2% had MBI (MBI+ status). Multivariable logistic regression analysis demonstrated that compared to those without MBI (MBI- status), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, 95% CI = 1.49–37.21, p = 0.02). Frailty and MBI were both significantly associated with both MMSE and MoCA-BC score (p < 0.05). Conclusions Both frailty and MBI status were associated with higher odds of cognitive impairment. MBI was significantly associated with an increased risk of having frailty in the absence of dementia. This association merits further study to identify potential strategies for the early detection, prevention and therapeutic intervention of frailty.

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Section: Neuropsychiatric and Neuropsychological Assessmentmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

et al. 2020

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“…The Alzheimer’s Disease Assessment Scale is mainly used for the assessment of treatment efficacy, while the NPI is generally used for the assessment of BPSD. Mild behavioral abnormalities are identified using the Chinese or English version of the Mild Behavioral Impairment Checklist (the sensitivity and specificity are 86.96% and 86.00%, respectively) [ 36 ]. Activity of daily living is mainly assessed using ADL and Pfeffer Functional Activities Questionnaire.…”

Section: Comprehensive Assessment Of Abc Symptomsmentioning

confidence: 99%

Comprehensive Management of Daily Living Activities, behavioral and Psychological Symptoms, and Cognitive Function in Patients with Alzheimer's Disease: A Chinese Consensus on the Comprehensive Management of Alzheimer's Disease

Jia

Liu

et al. 2021

Neurosci. Bull.

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Alzheimer's disease (AD) is the most common cognitive disorder in the elderly. Its main clinical manifestations are cognitive decline (C), behavioral and psychological symptoms (B), and a decline in the activities of daily living (A), also known as ABC symptoms. Early identification and evaluation of ABC symptoms are helpful for establishing the accurate diagnosis, comprehensive treatment, and prognosis of AD. To guide Chinese clinical practice for optimization of the comprehensive management of AD, in 2018, The Academy of Cognitive Disorder of China gathered 22 neurologists and gerontologists in China to build a consensus on the comprehensive management of AD. Based on a review of the evidence, the consensus summarizes the pathogenesis, pathological changes, clinical manifestations, evaluation, diagnosis, drug and non-drug treatment, and patient care for AD. Focus group discussion was used to establish a flowchart of comprehensive ABC management for AD patients. The new consensus provides a feasible AD management process for clinicians.

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“…MBI was assessed using the Chinese version of MBI-C developed by Cui (46), a scale developed speci cally for functionally independent community-dwelling older adults. The MBI-C(47) includes 34 items in ve domains: 1) decreased motivation (apathy), 2) emotional dysregulation (mood and anxiety symptoms), 3) impulse dyscontrol (agitation, aggression, impulsivity), 4) social inappropriateness (impaired social cognition), and 5) abnormal perception or through content (psychotic symptoms, i.e.…”

Section: Neuropsychiatric and Neuropsychological Assessmentmentioning

confidence: 99%

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Fan

Liang

Yun

et al. 2020

Preprint

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Background: Frailty and cognitive decline are highly prevalent among older adults. However, the relationship between frailty and mild behavioral impairment (MBI), a neurobehavioral syndrome characterized by later-life emergence of sustained neuropsychiatric symptoms, has yet to be elucidated.We aimed to evaluate the associations between mild behavioral impairment and frailty in non-dementia older adults.Methods: This is a cross-sectional study. A consecutive series of 137 non-dementia older adults in the Anti-Aging Study, recruited from primary care clinics, were enrolled. Frailty was estimated using the Fried phenotype. MBI was evaluated by the Mild Behavioral Impairment Checklist at a cut-off point of >8 (optimizing sensitivity and specificity), which was developed to assess emergent neuropsychiatric symptoms in accordance with the MBI criteria. Cognition was assessed with the Chinese versions of the Montreal Cognitive Assessment (MoCA-BC) and Mini-mental State Examination (MMSE). Multivariate logistic regression was performed to estimate the relationship between MBI and objective cognition with frailty status.Results: At baseline, 30.7% of the older adults had frailty and 18.2% had MBI (MBI+ status). Multivariate logistic regression analysis demonstrated that compared to MBI- status (without MBI), MBI+ was more likely to have frailty (odds ratio [OR] = 7.44, 95% CI = 1.49-37.21, p = 0.02).Conclusions: MBI is significantly associated with an increased risk of having frailty before the presence of overt dementia. This association merits further study to identify strategies for the early detection, prevention and therapeutic intervention of frailty.

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Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer’s Disease

Cited by 31 publications

References 33 publications

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

Comprehensive Management of Daily Living Activities, behavioral and Psychological Symptoms, and Cognitive Function in Patients with Alzheimer's Disease: A Chinese Consensus on the Comprehensive Management of Alzheimer's Disease

Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study

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