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Alzheimer's disease (AD) is the most common cognitive disorder in the elderly. Its main clinical manifestations are cognitive decline (C), behavioral and psychological symptoms (B), and a decline in the activities of daily living (A), also known as ABC symptoms. Early identification and evaluation of ABC symptoms are helpful for establishing the accurate diagnosis, comprehensive treatment, and prognosis of AD. To guide Chinese clinical practice for optimization of the comprehensive management of AD, in 2018, The Academy of Cognitive Disorder of China gathered 22 neurologists and gerontologists in China to build a consensus on the comprehensive management of AD. Based on a review of the evidence, the consensus summarizes the pathogenesis, pathological changes, clinical manifestations, evaluation, diagnosis, drug and non-drug treatment, and patient care for AD. Focus group discussion was used to establish a flowchart of comprehensive ABC management for AD patients. The new consensus provides a feasible AD management process for clinicians.

In this paper, we present a new version of the famous Rudin-Osher-Fatemi (ROF) model to restore image.The key point of the model is that it could reconstruct images with blur and non-uniformly distributed noise. We develop this approach by adding several statistical control parameters to the cost functional, and these parameters could be adaptively determined by the given observed image. In this way, we could adaptively balance the performance of the fit-to-data term and the regularization term. The Numerical experiments have demonstrated the significant effectiveness and robustness of our model in restoring blurred images with mixed Gaussian noise or salt-and-pepper noise.

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With the introduction of BIM Technology, the traditional construction project management model innovation will can to realize data sharing in a common platform to participate in many of the units, and the construction project management more convenient and effective. The due to long engaged in technology research and development and application of Bim and construction management, the future will be in construction project management of Bim and we were technology sharing and exchange, such as the construction schedule, cost, quality and safety control, application of Bim and construction simulation and construction green BIM application, and people, machine, material, method, central management of BIM applications.

Employees are main sources of innovative ideas via their insights of companies' products, processes, customers, and competitors. Enterprise crowdsourcing systems (ECSs) are used to collect, refine, and realize ideas. However, only a small percent of employees submit ideas-about 7.7% at Pfizer, 2% at HCL Technologies, and 3% at Polaris Industries. Why employee's participation is low? More specifically, what are the factors that can lead employees to use ECS actively to submit and share their innovative ideas for improving their job performance? In this research, we used a multi-actor dyadic survey to survey 183 employees and their managers and conducted data analysis to understand the impact of ECS factors on employees' job performance. The findings of this study can help organizations refine their ECSs and innovation initiatives.

Germanium phosphide (GeP), a rising star of novel two-dimensional (2D) material composed of Group IV–V elements, has been extensively studied and applied in photonics thanks to its broadband optical absorption, strong light–matter interaction and flexible bandgap structure. Here, we show the strong nonlinear optical (NLO) properties of 2D GeP nanoflakes in the broadband range with open-aperture Z-scan technique to explore the performance of 2D GeP microfiber photonic devices (GMPDs) in near-infrared (near-IR) and mid-infrared (mid-IR) ultrafast photonics. Our results suggest that employing the GMPD as an optical device in an erbium-doped fiber laser (EDFL) system results in ultrashort pulses and rogue waves (RWs) at 1.55 μm. Likewise, by the incorporation of GMPD into a thulium-doped fiber laser (TDFL) system, stable ultrashort pulse operation is also achieved at 2.0 μm. We expect these findings to be an excellent GMPD that can be applied in mode-locked fiber lasers to open up new avenues for its development and application in ultrafast photonics.