Relevance of Two Genes in the Multidrug Resistance of Hepatocellular Carcinoma: In Vivo and Clinical Studies

Sun, Zhen; Zhao, Zizhuo; Li, Gaopeng; Dong, Shaohong; Huang, Zhiyong; Lu, Ye; Liang, Huifang; Qu, Junyuan; Ai, Xi; Zhang, Wanguang; Chen, Xiaoping

doi:10.1177/030089161009600115

Cited by 48 publications

(45 citation statements)

References 31 publications

(57 reference statements)

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“…Different from our aforementioned findings, Sun et al 17) found that the expression of ABCC1 in HCC was similar to paracarcimoma tissues.…”

Section: Discussioncontrasting

confidence: 99%

“…Our results showed that preoperative TACE treatment didn't affect the expression of ABCB1, ABCC1 and ABCG2 in HCC, adjacent nonneoplastic and cirrhosis tissues (P>0.05, Table 3). This finding is different from the recent observation that TACE treatment improved the expression of ABCB1 and ABCG2 in HCC tissues while didn't have effect on ABCC1 expression 17,18) . In this study, most of the .…”

Section: Relationships Between the Expression Of Abcb1 Abcc1 And Abccontrasting

confidence: 95%

“…In this study, most of the . The variability of patients might result in the differences between our study and previous study 17) .…”

Section: Relationships Between the Expression Of Abcb1 Abcc1 And Abccontrasting

confidence: 59%

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Clinical Significance of ABC Transporter Expression in Patients with Hepatocellular Carcinoma

Fan

Zhang²,

Zhang

et al. 2016

J. Hard Tissue Biology.

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To gain insight into the clinical significance of expression of ABC transporter antigen in patients with hepatocellular carcinoma (HCC), we used immunohistochemistry to determine the patterns of ABCB1, ABCC1 and ABCG2 expression in 30 resected HCC tissues, 26 paired adjacent nonneoplastic tissues and 9 cirrhosis tissues accompanied with chronic hepatitis B virus infection in this study. It was found that the expression rates of ABCB1, ABCC1 and ABCG2 were 56.7 %, 93.3 % and 83.3 % in patients with HCC, respectively. ABCB1 and ABCC1 were expressed significantly differently among HCC, adjacent non-neoplastic and cirrhosis tissues. There were no significant differences in the clinical factors associated with the expression of these three ABC transporter antigens. Furthermore, preoperative TACE treatment didn't affect the expression of these three ABC transporters. Moreover, patients with higher expression of both ABCC1 and ABCB1 showed significantly shorter disease-free survival (DFS) than those with lower expression of both antigens (P<0.01).Therefore, higher expression of ABCC1 and ABCB1 might be an unfavorable prognostic factor in patients of HCC, and represent an important hurdle to chemotherapy.

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“…Different from our aforementioned findings, Sun et al 17) found that the expression of ABCC1 in HCC was similar to paracarcimoma tissues.…”

Section: Discussioncontrasting

confidence: 99%

Section: Relationships Between the Expression Of Abcb1 Abcc1 And Abccontrasting

confidence: 95%

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Clinical Significance of ABC Transporter Expression in Patients with Hepatocellular Carcinoma

Fan

Zhang²,

Zhang

et al. 2016

J. Hard Tissue Biology.

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“…It has been suggested that overexpression of P-gp but not MRP1 mainly contributes to the MDR of SMMC-7721/ADM cells (Yan et al, 2010). The upregulation of P-gp and BCRP but not MRP1 and LRP are involved in the MDR of HepG2/ADM cells (Li et al, 2007;Sun et al, 2010). Overexpression of P-gp is also a predominant mechanism to explain the MDR in a taxol-resistant cell line, QGY-TR50 (Zhou et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Characterization and Resistance Mechanisms of A 5-fluorouracil-resistant Hepatocellular Carcinoma Cell Line

Fang²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Overexpression of P-gp associated with the MDR phenotype of a taxol resistant cell line, QGY-TR50. [170][171][172] Small and Non-small Cell Lung Cancer (SCLC and NSCLC, respectively)…”

mentioning

confidence: 99%

The network of P-glycoprotein and microRNAs interactions

et al. 2013

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Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P‐gp may regulate the expression of miRs in the cell. Furthermore, both P‐gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P‐gp and miRs.

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Relevance of Two Genes in the Multidrug Resistance of Hepatocellular Carcinoma: In Vivo and Clinical Studies

Cited by 48 publications

References 31 publications

Clinical Significance of ABC Transporter Expression in Patients with Hepatocellular Carcinoma

Clinical Significance of ABC Transporter Expression in Patients with Hepatocellular Carcinoma

Characterization and Resistance Mechanisms of A 5-fluorouracil-resistant Hepatocellular Carcinoma Cell Line

The network of P-glycoprotein and microRNAs interactions

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