Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds

Serra, Tiziano; Ortiz-Hernández, Mónica; Engel, Elisabeth; Planell, Josep A.; Navarro, Melba

doi:10.1016/j.msec.2014.01.003

Cited by 173 publications

(137 citation statements)

References 28 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…The results firmly evidenced our hypothesis on the mechanism. Researches on the similar system reported by others [6,7] were also compared with our work, and we have confirmed the same mechanism from their results, which however were not concluded there.…”

Section: Introductionsupporting

confidence: 91%

“…In Ref. [7] the in-vitro degradation studies showed that the inclusion of PEG significantly accelerated the degradation rate of the PLA-based 3D printed tissue engineering scaffolds. This work employed PEG/PLA solution blend, and there is no thermal process so we assume the materials is amorphous.…”

Section: E Effect Of Miscibilitymentioning

confidence: 99%

“…Among numerous modifiers that have been researched, the excellent biocompatibility, biodegradability, non-toxicity and chain flexibility make the Polyethylene Glycol (PEG) a good choice for the modification for PLA, in either chemical way (e.g. the PLA-PEG block polymer) [5] or physical way (the blend mixture) [6][7][8][9][10][11][12]. Usually the PEG is used as the plasticizer to improve the mechanical properties of PLA [9,12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Striking Dispersion of Recrystallized Poly(ethylene glycol)-Poly(lactic acid) Solvent-Casting Blend

Zhu¹,

Huang²,

Zhong³

et al. 2015

View full text Add to dashboard Cite

The solvent casted Poly(ethylene glycol) (PEG) and Poly(lactic acid) (PLA) blend was recrystallized by the thermal treatment of a heating and cooling cycle. The high PEG content blend (30%wt) showed a striking dispersion behavior, that the materials rapidly dispersed and dissolved in the aqueous environment in a few hours. This phenomenon has not been reported by others, and was not observed in low PEG content samples of 5%, 10%, and 20%, or quenched(amorphous) samples. We hypothesized the mechanism that the chain rearrangement during the thermal treatment leads to the phase separation. And with the phase separation in the recrystallized samples, the PEG potions rapidly dissolved in the aqueous environment, left out the small PLA spherulites being separated and dispersed in the solution. The same underlying reason can also be inferred from the degradation behaviors of other samples. Characterizations of DSC, XRD, and SEM have been done to validate our hypothesis.

show abstract

Section: Introductionsupporting

confidence: 91%

Section: E Effect Of Miscibilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Striking Dispersion of Recrystallized Poly(ethylene glycol)-Poly(lactic acid) Solvent-Casting Blend

Zhu¹,

Huang²,

Zhong³

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The addition of the glass (and PEG) to the PLA matrix induced a more positive biological response, allowing cell (mesenchymal stem cells) adhesion and spreading on the biomaterial's surface [109]. The second study was aimed at identifying the optimal conditions for manufacturing PEG/PLA/CaP glass scaffolds via 3D printing [110]. Results showed that the incorporation of PEG in the PLA matrix could improve the matrix's wettability and elastic modulus.…”

Section: D Printing (3dp)mentioning

confidence: 99%

Bioactive Glass-Biopolymer Composites

Ding¹,

Souza²,

Li³

et al. 2015

Handbook of Bioceramics and Biocomposites

View full text Add to dashboard Cite

Tissue engineering (TE) is a biomedical field in continuous expansion. However, there are still many challenges, and the further development of TE approaches requires interdisciplinary interaction and collaboration among various research areas with a notable contribution expected from biomaterials science. In the last couple of decades, significant advances in the development of biomaterial-based scaffolds for hard and soft tissue regeneration have been accomplished, including the manufacture of biocomposites that combine natural or synthetic polymers with bioactive glasses or glass-ceramics. These novel biomaterials present the possibility of tailoring a variety of parameters and properties such as degradation kinetics, mechanical properties, and chemical composition according to the aimed application. This chapter presents a concise update of the field of biopolymer-bioactive glass composite scaffold development for TE covering several popular processing techniques for biocomposite fabrication, namely, microsphere processing, solvent casting-particulate leaching method, electrospinning, freezedrying, and rapid prototyping techniques, which lead to scaffolds exhibiting a variety of 3D morphologies and different pore structures.

show abstract

“…3), materials can be shaped into different forms depending on the processing techniques used to fabricate scaffolds (foaming [17,18], sintering [19], salt leaching [20], rapid-prototyping [21], electrospinning [22], etc). Each technique results in materials with specific pore size and interconnectivity, which can be controlled by varying the experimental parameters [23].…”

Section: Scaffold Architecturementioning

confidence: 99%

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Sachot¹,

Engel²,

Castaño

2014

COC

Self Cite

View full text Add to dashboard Cite

Abstract:The introduction of hybrid materials in regenerative medicine has solved some problems related to the mechanical and bioactive properties of biomaterials. Calcium phosphates and their derivatives have provided the basis for inorganic components, thanks to their good bioactivity, especially in bone regeneration. When mixed with biodegradable polymers, the result is a synergic association that mimics the composition of many tissues of the human body and, additionally, exhibits suitable mechanical properties. Together with the development of nanotechnology and new synthesis methods, hybrids offer a promising option for the development of a third or fourth generation of smart biomaterials and scaffolds to guide the regeneration of natural tissues, with an optimum efficiency/cost ratio. Their potential bioactivity, as well as other valuable features of hybrids, open promising new pathways for their usein bone regeneration and other tissue repair therapies. This review provides a comprehensive overview of the different hybrid organic-inorganic scaffolding bio-materials developed so far for regenerative therapies, especially in bone. It also looks at the potential for research into hybrid materials for other, softer tissues, which is still at an initial stage, but with very promising results.

show abstract

Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds

Cited by 173 publications

References 28 publications

Striking Dispersion of Recrystallized Poly(ethylene glycol)-Poly(lactic acid) Solvent-Casting Blend

Striking Dispersion of Recrystallized Poly(ethylene glycol)-Poly(lactic acid) Solvent-Casting Blend

Bioactive Glass-Biopolymer Composites

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Contact Info

Product

Resources

About