Relevance of Human Papillomaviruses in Head and Neck Cancer—What Remains in 2021 from a Clinician’s Point of View?

Hoffmann, Markus; Quabius, Elgar Susanne

doi:10.3390/v13061173

Cited by 12 publications

(9 citation statements)

References 95 publications

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“…HPVs have less than 90% resemblance to other nucleotide levels. 9 , 10 More than 150 genotypes of HPV have been identified by DNA sequencing and were stratified according to oncogenic risk. Seventeen genotypes are clearly linked to the development of adenocarcinoma and squamous cell carcinoma of the cervix and therefore were ranked as high-risk HPV: −16, −18, −31, −33, −35, −39, −45, −51, −52, −53,56, −58, −59, −66,-68, −73, and −82.…”

Section: Introductionmentioning

confidence: 99%

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Wang¹,

Chen²,

Jiang³

2021

CMAR

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Objective Human papillomavirus (HPV) infection is the risk factor for cervical cancer. Consequently, HPV DNA testing is an essential method for cervical cancer screening. Yet, data on the prevalence and genotype distribution of HPV and cervical cytological among women in northern Jiangsu Province of China are very limited. Materials and Methods A total of 36,500 women were enrolled at the Department of Pathology of Jinhu County People’s Hospital between January 1, 2016 and December 31, 2019. HPV genotypes was performed using YanengBio ® Human Papillomavirus Genotyping Kit. Thin liquid cytology tests (TCT) were conducted, based on cytology conditions set by Bethesda in 2001. Results The overall prevalence of HPV infection was 28.95%; it was age-dependent; the number of infections was highest in the 40–49 age group. Six thousand three hundred eighty-two women (16.87%) were found to have a pure high-risk HPV infection, while 918 women (2.43%) were found to have a pure low-risk HPV infection. The 6 most predominant genotypes were HPV 52, 58, 16, 53, 56, and 33. Moreover, 8923 women (45.09%) were affected by ASCUS, 4531 (22.90%) by LSIL, 3726 (18.83%) by ASC-H, and 2610 (13.19%) by HSIL. Conclusion This study revealed a high burden of HPV infection among women in northern Jiangsu Province of China and identified the distribution of the prevalent top 6 HPV genotypes in this area, which can be used as a useful reference for future work.

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Section: Introductionmentioning

confidence: 99%

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Wang¹,

Chen²,

Jiang³

2021

CMAR

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“…The International Agency for Research on Cancer (IARC) under the World Health Organization (WHO) has classified the mucosotropic alpha‐genus HPV genotypes into high‐risk (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) and low‐risk (HPV6 and 11, among others) genotypes based on their carcinogenic potential in the uterine cervix (International Agency for Research on Cancer, 2012a ). Of the high‐risk genotypes, HPV16 and 18 harbor the highest malignant potential, which together are responsible for more than 70% of all cervical carcinomas and 95% of all oropharyngeal SCC (Bonde et al, 2020 ; Hoffmann & Quabius, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus‐related neoplasia of the ocular adnexa

Ramberg

2022

Acta Ophthalmologica

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SummaryHuman papillomaviruses (HPV) are involved in approximately 5% of solid cancers worldwide. The mucosotropic genotypes infect the stratified epithelium of various locations, where persistent infection may lead to invasive carcinomas. While the causative role of HPV in certain anogenital and head and neck carcinomas is well established, the role of HPV in carcinomas arising in the mucosal membranes of the ocular adnexal tissue (the lacrimal drainage system and the conjunctiva) has been a topic of great uncertainty. Therefore, we conducted a series of studies to assess the correlation between HPV and carcinomas arising in the mucosa of the ocular adnexal tissue and characterize the clinical, histopathological, and genomic features of the tumors in the context of HPV status in a Danish nationwide cohort.We collected clinical and histopathological data and tumor specimens from patients with carcinomas of the conjunctiva and the lacrimal drainage system, and their potential precursors, identified in Danish nationwide registries. The HPV status of the tumors was determined by the combined use of HPV DNA polymerase chain reaction (PCR), HPV E6/E7 mRNA in‐situ hybridization, and p16 immunohistochemistry. The genomic profile was investigated by high‐throughput DNA sequencing targeting 523 cancer‐relevant genes. The literature to date on carcinomas of the lacrimal drainage system and the conjunctiva was summarized.In the Danish cohort, 67% of all carcinomas of the lacrimal drainage system and 21% of all conjunctival carcinomas were HPV‐positive. HPV16 was the most frequently implicated genotype. A full‐thickness expression of the viral oncogenes E6 and E7 was evident in almost all HPV DNA‐positive cases. The HPV‐positive carcinomas of the conjunctiva and the lacrimal drainage system shared histopathological and genomic features distinct from their HPV‐negative counterparts. The HPV‐positive carcinomas were characterized by a non‐keratinizing morphology, p16 overexpression, high transcriptional activity of HPV E6/E7, and frequent pathogenic variants in the PI3K‐AKT signaling cascade. In contrast, the HPV‐negative carcinomas were characterized by a keratinizing morphology, lack of p16 and E6/E7 expression, and frequent somatic pathogenic variants in TP53, CDKN2A, and RB1. Among the patients with conjunctival tumors, HPV positivity was associated with a younger age at diagnosis and a higher risk of recurrence.In conclusion, the results support an etiological role of HPV in a subset of conjunctival and LDS carcinomas and their precursor lesions. Our investigations have shown that the HPV‐positive carcinomas of the ocular adnexa share genomic and phenotypic characteristics with HPV‐positive carcinomas of other anatomical locations. Therefore, these patients may be eligible for inclusion in future basket trials and future treatment regimens tailored to the more frequently occurring HPV‐positive carcinomas of other locations. Future research will further elucidate the diagnostic, prognostic, and predictive role of HPV in these carcinomas.

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“…The prevalence of HPV has been studied in different countries (3). Some studies have indicated an association between HPV and other cancers, such as lung, breast, esophageal, colon and rectum, and prostate cancers; however, a recurrent causal relationship between these cancers and the virus has not been shown (4,5).…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus prevalence in unexplained infertile women with chronic endometritis

AĞAR¹,

MADENLİ>

Gürbüz³

2022

Journal of Health Sciences and Medicine

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Introduction: This study investigates unexplained infertile women with or without chronic endometritis (CE) and examines the prevalence of the human papillomavirus (HPV) in this population. Material and Method: This study was done with a cross-sectional and retrospective method. The prevalence of HPV infection and related cases in the participants were examined. In this study, 15 infertile women with CE and 64 infertile women without CE were and analyzed from four perspectives: negative HPV, low-risk HPV, probable high-risk HPV, and the presence of high-risk HPV. Results: The participants have mean age of 32.89 years ±3.95. High-risk HPV infection was detected in 3 (20%) and 11 (17%) of the patients with and without CE, respectively (p>0.05). The negative HPV (2 (13%) and 17 (26%)), low-risk HPV (3 (20%) and 20 (31%)), and probable high-risk HPV (7 (46%) and 16 (25%)) in infertile women with CE and infertile women had no significantly different prevalence (p>0.05). The two studied groups had no significantly different mean age, body mass index (BMI), and Infertility duration were not in (P=0.08, P=0.932, and P=0.283, respectively). Conclusion: HPV has no significantly different prevalence in unexplained infertile women with and without CE. It is recommended that this study be repeated with more unexplained infertile women with CE.

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Relevance of Human Papillomaviruses in Head and Neck Cancer—What Remains in 2021 from a Clinician’s Point of View?

Cited by 12 publications

References 95 publications

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Human papillomavirus‐related neoplasia of the ocular adnexa

Human papillomavirus prevalence in unexplained infertile women with chronic endometritis

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