Introduction: Polycystic ovary syndrome (PCOS) causes endocrine disorders that affect the functioning of the reproductive system and the body's metabolic system. Bowel movement disorders and abdominal pain are common complaints of PCOS patients. Few studies have been performed on the relationship between PCOS and irritable bowel syndrome (IBS), and the association between the two syndromes is unclear. Material and Method: In the study, 72 patients were enrolled at gynecology and obstetric clinic in Turkey. The control group were (n=34) and women with PCOS (n=38). IBS diagnosis was made by using Roma IV criteria. Results: The results showed that IBS prevalence was similar in PCOS (52%) and the control group (50%) (p>0.05). No statistically significant association was found between IBS-PCOS and non-IBS-PCOS in terms of gastrointestinal symptoms (p=0.685). These symptoms were associated with PCOS rather than IBS. Significant differences have been observed between IBS-PCOS and non-IBS-PCOS for fasting insulin (FI), luteinizing hormone (LH) and Homeostasis model assessment for insulin resistance (HOMA-IR) (p
Aim: In frozen-thawed embryo transfers (FET), Gonadotropin-Releasing Hormone (GnRH) agonists have recently been used to improve implantation results. It is preferred to administer it in the luteal phase of the previous cycle. The objective was to compare the effects of different administration days of depot GnRH agonists on implantation and pregnancy rates in the artificial cycle of FET. Material and Method: A retrospective case-control study was conducted in an in vitro fertilization (IVF) center in a university hospital, including all women starting an artificial cycle of FET. One thousand two hundred and twenty-seven (n:1227) FET cycles were scanned from the files from October 2014 to December 2021. Depot agonists (Lucrin depot 3.75 mg sc Abbott USA.-leuprolide acetate) were used in 219 patients with endometriosis. In 58 patients, it was administered on day 21 of the previous cycle (Group 1), and in 161 patients, it was administered on day 2 of the same cycle (Group 2). Results: This study showed no statistically significant difference between the two groups in laboratory parameters and endometrial thickness (p>0.05). There was no statistically significant association between the abort rate and transfer day (p>0.05). There was no statistically significant association between the pregnancy results and transfer day (p>0.05). The ongoing pregnancy rate (OPR) rate was relatively high in the second group compared to the twenty-first day of the previous cycle (87/161(54%) vs. 30/58 (51.7%)). The biochemical pregnancy was relatively high in the second-day group compared to the twenty-first day of the previous cycle (62/161(38.5%) vs. 21/58 (36.2%)). The abort rate was relatively high in the twenty-first-day group compared to the second day of the cycle (25/87(28.75%) vs. 9/30(30%)). Conclusion: In conclusion, the impacts of various administration days of depot Gonadotropin-releasing hormone (GnRH) agonists on implantation and pregnancy rates were not statistically significant.
Objective: To compare the perinatal and maternal results of intrahepatic cholestasis (ICP) in fresh and frozen-thawed embryo transfer (ET) pregnancies. Material and Method: This research was performed retrospectively, including fourty-five pregnant women applied to our hospital between October 2010 and January 2021. Two groups have been determined, group:1 (Frozen thawed; n:21) and group:2 (Fresh; n:24). Common pruritus in the body and high fasting bile acids (FBA) levels (greater than 10 mmol/L) were accepted as diagnostic criteria. The exclusion criteria were spontaneous pregnancies, multiple pregnancies, chronic liver disease history. SPSS, version 26 was used for statistical analysis. Results: Statistically significant difference could not be associated between the two groups regarding age, maternal body mass index (BMI), smoking status, number of trials, gestational diabetes mellitus (GDM), types of infertility and polycystic ovary syndrome (PCOS) incidence (p-value >0.05). The way of birth, gender, congenital anomaly, need for meconium aspiration syndrome (MAS), weight of newborn at birth, neonatal intensive care unit (NICU), gestational age at birth and 5 min Apgar score also compared and significantly difference could not be associated between two groups (p-value > 0.05). Conclusion: This study supports the fact that frozen-thawed and fresh in vitro fertilization (IVF) pregnancies in terms of maternal characteristics and perinatal results have no difference.
Aim: In this study, the fertility rate of women with polycystic ovary syndrome (PCOS) and endometriosis was compared with the control group, which included women with normoresponder (NR) endometriosis. Material and Method: This is a retrospective study with control in infertile women aged 25-40, suffering from PCOS and endometriosis, referred to the infertility clinic of Medistate Hospital between September 2018- December 2020. The pregnancy outcomes of age-matched participants were compared. Results: Results did not show a statistically significant association between case and control regarding age and body mass index (BMI) (p>0.05). There was a statistically significant difference between groups regarding anti-mullerian hormone (AMH) (p0.05). Conclusion: Women with PCOS and endometriosis did not show a significant difference in terms of pregnancy outcome compared to women with NR women with endometriosis.
Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy (HRT) with gonadotropin releasing hormone analogue (GnRH-a) suppression, HRT without GnRH-a suppression and mild ovarian stimulation (OS) for women with polycystic ovary syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET).Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the “freeze-all” strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression (n=43); HRT without GnRH-a suppression (n=86); mild-OS (n=32).Results: The biochemical pregnancy results (55.8 % vs 54.65 % vs 53, p=0.900), ongoing pregnancy rates (44.2 % vs 43 % vs 40.62, p=0.572), and abort rates (20.8 % vs 21.3 % vs 23.52, p=0.900) were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters (p>0.05). Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.
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