Release Studies on Niosomes Containing Fatty Alcohols as Bilayer Stabilizers Instead of Cholesterol

Devaraj, Gopi N.; Parakh, Sagun; Devraj, Ravi; Apte, S. S.; Rao, B. Ramesh; Rambhau, D.

doi:10.1006/jcis.2002.8399

Cited by 150 publications

(95 citation statements)

References 26 publications

(20 reference statements)

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“…The niosomal formulation with a high cholesterol content (50% of the total lipid content) was found to have high entrapment efficiency, and could be due to the improved stability of the niosomes achieved by addition of cholesterol, which has been reported to stabilize the bilayers, prevent leakage of drug components, and retard permeation of solutes enclosed in the aqueous core of niosomes. 35 Table 1 shows that the preparation processes were controlled under appropriate conditions to obtain the optimal formulation. Although F1 was shown to achieve the highest entrapment efficiency in this study, the drug loading rate, which represents the drug content in the formulation, was the lowest (9%, w/w).…”

Section: Resultsmentioning

confidence: 99%

Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

Jin¹,

Wen²,

Garg³

et al. 2013

IJN

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Background:The aim of this study was to develop an optimal niosomal system to deliver Ginkgo biloba extract (GbE) with improved oral bioavailability and to replace the conventional GbE tablets. Methods: In this study, the film dispersion-homogenization method was used to prepare GbE niosomes. The resulting GbE niosome suspension was freeze-dried or spray-dried to improve the stability of the niosomes. GbE-loaded niosomes were formulated and characterized in terms of their morphology, particle size, zeta potential, entrapment efficiency, and angle of repose, and differential scanning calorimetry analysis was performed. In vitro release and in vivo distribution studies were also carried out. Results: The particle size of the optimal delivery system prepared with Tween 80, Span 80, and cholesterol was about 141 nm. There was a significant difference (P , 0.05) in drug entrapment efficiency between the spray-drying method (about 77.5%) and the freeze-drying method (about 50.1%). The stability study revealed no significant change in drug entrapment efficiency for the GbE niosomes at 4°C and 25°C after 3 months. The in vitro release study suggested that GbE niosomes can prolong the release of flavonoid glycosides in phosphate-buffered solution (pH 6.8) for up to 48 hours. The in vivo distribution study showed that the flavonoid glycoside content in the heart, lung, kidney, brain, and blood of rats treated with the GbE niosome carrier system was greater than in the rats treated with the oral GbE tablet (P , 0.01). No flavonoid glycosides were detected in the brain tissue of rats given the oral GbE tablets, but they were detected in the brain tissue of rats given the GbE niosomes. Conclusion: Niosomes are a promising oral system for delivery of GbE to the brain.

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Section: Resultsmentioning

confidence: 99%

Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

Jin¹,

Wen²,

Garg³

et al. 2013

IJN

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“…(Runothayanun et al, 1999). Niosomes as drug delivery vesicles, increases absorption of some drugs through cell membranes and cellular uptake via endocytosis (Baillie et al, 1985) and so confines the drug in tissues and targeted organs (Namdeo & Jain et al, 1999) and also helps to evade the reticuloendothelial system (Devaraj et al, 2002). Various applications of proniosomes are shown in Table 3.…”

Section: Proniosomes As Drug Carriersmentioning

confidence: 99%

A review on novel vesicular drug delivery: proniosomes

et al. 2013

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Nanotechnology has brought a revolution in the field of science, which has subsequently lead to development of novel dosage forms such as niosomes, liposomes and proniosomes. Proniosomes overcome the demerits involved with niosomal and liposomal drug delivery systems. Proniosomes are liquid crystalline compact niosome hybrids which upon hydration form niosomes. They help in reducing physical stability problems involved with niosomes such as leaking, fusion, aggregation and provide convenience in dosing, distribution, transportation and storage showing improved results than conventional niosomes. This review focuses on different aspects of proniosome such as preparation, characterization, drug release, applications, merits, demerits, present scenario in market and future trends.

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“…However, there are some setbacks in AZT administration, including hematological toxicity, poor bioavailability, high first-pass metabolism, and short half-life [54]. A study revealed that niosomal AZT formulation prolonged the drug half-life in rabbit serum [55]. In another study, niosomes manufactured with Tween 80 were able to encapsulate a high amount of AZT, and addition of dicetyl phosphate enhanced drug release for a prolonged period (88.72% over 12 h).…”

Section: Acquired Immune Deficiency Syndromementioning

confidence: 99%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

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Release Studies on Niosomes Containing Fatty Alcohols as Bilayer Stabilizers Instead of Cholesterol

Cited by 150 publications

References 26 publications

Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

Development of a novel niosomal system for oral delivery of Ginkgo biloba extract

A review on novel vesicular drug delivery: proniosomes

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

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