Release studies from smart hydrogels as carriers for piroxicam and copper(II)–oxicam complexes as anti-inflammatory and anti-cancer drugs. X-ray structures of new copper(II)–piroxicam and –isoxicam complex molecules

Synthesis, and Electrochemical and Density Functional Studies of New Copper(II)‐ and Manganese(II) Oxicam Drugs. Redox Potentials and MOs Compatible with SOD‐like Activity and Unusual Six‐membered Rings of Water Molecules Bridging Complex Units

“…The existence of those species was predicted even through the loading/release studies of Cu II (HTEN) 2 complexes from smart hydrogels, based on spectroscopy (UV/Vis, IR) and quantitative analytical data (AAS). [24] The present work reports on a sound test for the predictions previously claimed from this laboratory. As regards the arrangement of six H 2 O molecules (two aqua and four water) that pair two Cu II (HTEN) 2 entities, it has to be noticed that such a connection between coordination molecules has been found and reported for the first time (at our knowledge).…”

“…The solid was dried in an air atmosphere. The crude solid was subsequently used for loading and releasing studies on smart hydrogels as reported in Ref [24]. In the case the cmh2 hydrogel was used (see Ref [24] for the meaning of acronyms) a solution of crude Cu II (HTEN) 2 ·xSolvent in DMF was prepared by dissolving 15 mg in 5 mL of solvent.…”

“…The crude solid was subsequently used for loading and releasing studies on smart hydrogels as reported in Ref [24]. In the case the cmh2 hydrogel was used (see Ref [24] for the meaning of acronyms) a solution of crude Cu II (HTEN) 2 ·xSolvent in DMF was prepared by dissolving 15 mg in 5 mL of solvent. A properly swelled cmh2 hydrogel (5 mg of dry hydrogel previously soaked for 24 h in DMF) was taken off the swelling solution and then soaked in the green DMF/Cu II (HTEN) 2 medium.…”

4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors

“…Previous work reported its participation. 30 The TG thermogram of [Cu(EX15)(OAc)(H 2 O) 2 ] shows a thermal stability till 221 °C. A decomposition stage at 222-276 °C with weight loss of 5.5 (Anal.…”

New platinum–oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

“…The metal complex has to fit certain criteria such as: an optimal kinetic inertness/liability so that the coordination molecules can be transported in the blood stream and can pass certain protection barriers without major alteration; a suitable lipophilicity/hydrophobicity ratio that allows the absorption by specific media and tissues; a pharmacological activity from the free ligand and a high ability of the metal center to significantly interfere with DNA replication and with genetic information transfer; reduced toxicity towards healthy cells and healthy organs. The method used by some of us for contributing to point (b) is that of loading the metal complexes into certain hydrogels (so-called smart hydrogels) that are sensitive to temperature, pH, ionic strength and then allowing the release of the metal complexes after the gels are soaked into aqueous media [14,17,18]. In principle, the loaded gels can be implanted in the living tissues close to the target, as the gels themselves are innocent.…”